Results 91 to 100 of about 589,778 (268)
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Efficient Use of Renewable Solar Energy Resource for Electric Vehicles: Opportunities and Challenges
Engineering ReportsThis research delves into innovative solutions for integrating renewable solar energy into electric vehicle (EV) systems to mitigate limitations associated with battery storage and charging infrastructure.
Abdul Rahim +4 more
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Two-phase thermosiphons: Technology for the efficient and rational use of energy
Ingeniare: Revista Chilena de IngenieríaAccording to the National Energy Efficiency Plan 2022-2026, one of the most commonly used forms of measuring a country’s energy efficiency is the ratio between energy consumption and gross domestic product.
Luis H.R. Cisterna
doaj
Fuel and power resources based on energy-saving technologies and technical means in agriculture
Сельскохозяйственные машины и технологии, 2015 The state and efficiency of the use of the energy supply systems in agriculture were analyzed. It is demonstrated that grids and power equipment deterioration exceeds 30 percent, and fuel volume-efficiency ratio is not more than 35 percent in this sector.
A. V. Tikhomirov +2 more
doaj
Energy use – in terms of efficiency
Acta Agraria Debreceniensis, 2016 In the recent decades it has become apparent that the human race can lead to a polluting and energy- wasting lifestyle and the depletion of natural resources and an ecological disaster as well. Energy efficiency is the realization of the chance to see a wider use of renewable energy.
openaire +2 more sources
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source