Results 31 to 40 of about 346,065 (304)
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Journal of Civil Engineering and Management, 2014 Seismic resistance and cost effectiveness are often two important building planning objectives for architects. However, these objectives nearly always share a negative correlation with each other, which can cause planning delays and confusion.
Min-Yuan Cheng, Ching-Shan Chen
doaj +1 more source
Modely analýzy obalu dat s fixním součtem výstupů
Trendy v podnikání, 2022 Traditional data envelopment analysis (DEA) models do not consider any relations with respect to the sum of values of outputs. In many real applications, the sum of outputs is predetermined and cannot be changed.
Josef Jablonský
doaj +1 more source
Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum
FEBS Open Bio, EarlyView.Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik +6 more
wiley +1 more source
Constructing an optimal investment portfolio for the Bank of Lithuania
Ekonomika, 2016 The main goal of this article is to illustrate the strategy, devised to improve the effectiveness of utilizing the financial assets, or in this case, the official international reserves, belonging to the Bank of Lithuania.
Birutė Galinienė +1 more
doaj +1 more source
Graph Search-Based Exploration Method Using a Frontier-Graph Structure for Mobile Robots
Sensors, 2020 This paper describes a graph search-based exploration method. Segmented frontier nodes and their relative transformations constitute a frontier-graph structure.
Hyejeong Ryu
doaj +1 more source
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
A new methodology for deriving the efficient frontier of stocks portfolios: An advanced risk-return model [PDF]
Journal of Artificial Intelligence and Data Mining, 2014 In this paper after a general literature review on the concept of Efficient Frontier (EF), an important inadequacy of the Variance based models for deriving EFs and the high necessity for applying another risk measure is exemplified.
Sh. Mehrjoo, M. Jasemi, A. Mahmoudi
doaj +1 more source
Efficiency, Inefficiency and the MENA Frontier [PDF]
SSRN Electronic Journal, 2015 We examine technical efficiency in the Middle East and North Africa (MENA). In addition to economic indicators, political and social ones play a role in development and efficiency profiles. The MENA have been characterized by increasing economic efficiency over time but with marked polarization.
McAdam, Peter, Christopoulos, Dimitris
openaire +3 more sources
Aging Is a Key Driver for Adult Acute Myeloid Leukemia
Aging and Cancer, EarlyView.Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley +1 more source