Results 191 to 200 of about 272,567 (316)

Ciclopirox Olamine Inhibits the NLRP3 Inflammasome to Alleviate Inflammatory Diseases

Advanced Science, EarlyView.
There is no drug targeting the NLRP3 inflammasome that has been approved for use in clinical settings. Ciclopirox olamine (CPX), an antifungal agent approved by the US Food and Drug Administration (FDA), is identified as a specific and potent NLRP3 inflammasome inhibitor. CPX targets the NACHT domain of NLRP3 at Y381 to impair NLRP3 oligomerization and
Xinyu Xia, Hui You, Ke Zhang, Hui Jiang, Hongping Liu, Lianghua Liu, Aijie Zhang, You Zhou   +7 more
wiley   +1 more source

The EnvZ/OmpR two-component regulatory system regulates biofilm formation in <i>Salmonella pullorum</i> via interaction with the LuxS/AI-2 quorum sensing system and activation of the SoxR-AcrAB-TolC pathway. [PDF]

Front Microbiol
Liang J, Chen W, Wang C, Wang M, Wei P, Xu Z.   +5 more
europepmc   +1 more source

A High‐Entropy Strategy for Chemoresistive Ethanol Sensors With Remarkably Rapid and Selective Response

Advanced Science, EarlyView.
The configurational‐entropy strategy enables rapid and sensitive ethanol detection using a multicomponent oxide. The high‐entropy (InSnFeZnW)Ox provides enriched oxygen vacancies and diverse adsorption sites that strengthen surface reactivity. The sensor achieves a 5135% ethanol response with fast kinetics and stable long‐term operation.
Gi Baek Nam, Jin Ho Seo, Youngmin Kim, Hyuk Jin Kim, Yeong Jae Kim, Seon Ju Park, YunKyung Kim, Hyeon‐Min Yu, Jiwoo Lee, Ji Hyeon Lim, Jiheon Lim, Jong Hun Kang, WooChul Jung, Jong Jin Jung, Jeong Woo Han, Seung Eon Moon, Seong Ju Hwang, Jong‐Hoon Kang, Zhigang Zhu, Ho Won Jang   +19 more
wiley   +1 more source

Medicinal Plants: A Promising Therapeutic Approach for Addressing Antimicrobial Resistance. [PDF]

Int J Mol Sci
Zhou H, Du J, Jia M, Li Y, Zheng K.
europepmc   +1 more source

Dual‐Substrate Synergistic Photocatalysis: Exogenous Reagent‐Free Co‐Removal of Phenol and Cr(VI) via Electron‐Donor‐Mediated Redox Coupling over Modified Carbon Nitride

Advanced Science, EarlyView.
An exogenous reagent‐free dual‐substrate strategy harnesses phenol as an intrinsic electron donor to drive synchronous phenol degradation and Cr(VI) reduction over modified carbon nitride. π–π stacking and hydrogen bonding direct electron transfer to the catalyst, enriching photogenerated electrons and accelerating Cr(VI) reduction 6.4‐fold. This waste‐
Xiaoman Zhang, Qiyu Wang, Xiaodan Liu, Shuqi Wan, Cuiwei Du, Qilu Li, Chongfei Yu, Shuying Dong, Xianfa Su, Chun Hu   +9 more
wiley   +1 more source

Whole-genome sequence data of a multidrug-resistant <i>Klebsiella pneumoniae</i> strain KP-S-66 isolated from cattle shed soil. [PDF]

Data Brief
Akther S, Gilman MAA, Shahadat MN, Juli MSB, Hoque MN.   +4 more
europepmc   +1 more source

Senescent Cell Derived Artificial Vesicle‐Based Senolytic Sonovaccine Platform with Augmented Lymph Node Delivery and Antigen Cross‐Presentation Efficacy

Advanced Science, EarlyView.
A senolytic sonovaccine platform (SenoVac) is developed, in which senescent cell‐derived vesicles serve as broad senescent cell antigen reservior. The “2‐step” click chemistry strategy for effective lymph node delivery, and ultrasound‐triggered endosomal escape to boost cross‐presentation, ensures efficient senescent cell clearance and disease ...
Liang Zhang, Yubo Lai, Jia Wang, Lingling Liu, Jieyuan An, Mi Qu, Yuan Liang, Bijun Tan, Guodong Yang, Xuekang Yang, Lijun Yuan   +10 more
wiley   +1 more source

Co-Selection of Antibiotic and Disinfectant Resistance in Bacteria Isolated from Reusable Blood Collection Tourniquets: Implications for Infection Control. [PDF]

J Clin Med
Szymczyk J, Jaskulak M, Zorena K, Mędrzycka-Dąbrowska W.   +3 more
europepmc   +1 more source

Noninvasive Characterization of Tumor Heterogeneity in HNSCC: From Clinical Utility to Biological Correlates

Advanced Science, EarlyView.
This study establishes a CT‐based radiomics framework to quantify intratumoral heterogeneity (ITH) in HNSCC. Using unsupervised clustering, tumor ROIs and VOIs are analyzed to calculate 2D/3D ITH scores. The score shows strong predictive value for prognosis and immunotherapy response, and is associated with tumor metabolism and immune microenvironment,
Xinwei Chen, Rui Liu, Yuan Zhou, Yin Xiao, Chengmin Feng, Lin Chen, Yanshi Li, Mengna Wang, Zhaobo Cheng, Yuxi Luo, Long Liu, Lijing Niu, Yue Xiang, Juan Peng, Guohua Hu, Min Pan   +15 more
wiley   +1 more source

Synergy Between the Auranofin Analogue PEt₃AuCl and Membrane Disruptors, Efflux-Pump Blockers, and Glutathione-Depletors Uncovers Tolerance Pathways in <i>Pseudomonas aeruginosa</i>. [PDF]

Int J Mol Sci
Amato B, Mazzantini D, de Azevedo-França JA, Maisetta G, Ghelardi E, Esin S, Messori L, Batoni G.   +7 more
europepmc   +1 more source