Results 261 to 270 of about 272,567 (316)
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Current Opinion in Infectious Diseases, 1999
Bacterial genomes sequenced to date almost invariably contain genes apparently coding for multidrug efflux pumps, and the yeast genome contains more than 30 putative multidrug efflux genes. Thus it is not surprising that multidrug efflux is a major cause of intrinsic drug resistance in many microorganisms, and plays an even more prominent role in ...
H, Nikaido, H I, Zgurskaya
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Bacterial genomes sequenced to date almost invariably contain genes apparently coding for multidrug efflux pumps, and the yeast genome contains more than 30 putative multidrug efflux genes. Thus it is not surprising that multidrug efflux is a major cause of intrinsic drug resistance in many microorganisms, and plays an even more prominent role in ...
H, Nikaido, H I, Zgurskaya
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Extratubular efflux and nephropathy
Acta Pathologica Japonica, 1984The extratubular efflux of periodic acid‐Schiff (PAS) positive material is used as a histological indicator of intrarenal reflux, and correlation of the PAS positive material and interstitial as well as glomerular changes were analyzed in 114 surgical specimens consisting of renal calculi, hydronephrosis, vesicoureteral reflux, and others.
H, Shigematsu, S, Murakami, B, Akikusa
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Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2001
Efflux of free cholesterol (FC) continues even when cellular FC mass is unchanged. This reflects a recirculation of preformed FC between cells and extracellular fluids which has multiple functions in cell biology including receptor recycling and signaling as well as cellular FC homeostasis. Total FC efflux is heterogeneous.
C J, Fielding, P E, Fielding
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Efflux of free cholesterol (FC) continues even when cellular FC mass is unchanged. This reflects a recirculation of preformed FC between cells and extracellular fluids which has multiple functions in cell biology including receptor recycling and signaling as well as cellular FC homeostasis. Total FC efflux is heterogeneous.
C J, Fielding, P E, Fielding
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Angiotensin and norepinephrine efflux
European Journal of Pharmacology, 1969Abstract Rabbit aortae were equilibrated with labelled norepinephrine and the effects of various drugs on efflux of the catecholamine studied. Angiotensin amide (10 μg/ml) given at a rate of 0.18 ml/min increased norepinephrine efflux. Tyramine (100 μg/ml), cocaine (50 μg/ml), guanethidine (250 μg/ml), 0.25 and 0.4 M KCl, and acetylcholine (1 mg/ml ...
B K, Kiran, P A, Khairallah
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Transintestinal cholesterol efflux
Current Opinion in Lipidology, 2010Regulation of cholesterol homeostasis is a complex interplay of a multitude of metabolic pathways situated in different organs. The liver plays a central role and has received most attention of the research community. In this review, we discuss recent progress in the understanding of the emerging role of the intestine in cholesterol transport.In recent
Astrid E, van der Velde +2 more
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Bacterial efflux systems and efflux pumps inhibitors
Biochimie, 2005It is now well established that bacterial resistance to antibiotics has become a serious problem of public health that concerns almost all antibacterial agents and that manifests in all fields of their application. Among the three main mechanisms involved in bacterial resistance (target modification, antibiotic inactivation or default of its ...
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Clinica Chimica Acta, 1973
Abstract Evidence is presented to suggest that enzyme protein retention in the cell depends on adequate adenosine triphosphate (ATP), and the behaviour of erythrocytes seems to support this. Further evidence suggests that retention is mediated within the cell and not simply by the cell membrane, which appears permeable to enzyme molecules.
J C, Sweetin, W H, Thomson
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Abstract Evidence is presented to suggest that enzyme protein retention in the cell depends on adequate adenosine triphosphate (ATP), and the behaviour of erythrocytes seems to support this. Further evidence suggests that retention is mediated within the cell and not simply by the cell membrane, which appears permeable to enzyme molecules.
J C, Sweetin, W H, Thomson
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ArsM-mediated arsenite volatilization is limited by efflux catalyzed by As efflux transporters
Chemosphere, 2020Arsenic (As) methylation is regarded as an efficient strategy for As contamination remediation by As volatilization. However, most microorganisms display low As volatilization efficiency, which is possibly linked to As efflux transporters competing for cytoplasmic As(III) as a substrate. Here, we developed two types of As biosensors in Escherichia coli
Pengmin Yang +7 more
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Current Drug Targets, 2008
We have developed a number of methods that identify efflux pump mediated multi-drug resistant bacteria, characterize efflux systems and screen for inhibitors of efflux pumps. These approaches were complemented by the quantification of the expression of genes that regulate and code for constituents of efflux pumps. The methods described are easy to use,
Viveiros, M +8 more
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We have developed a number of methods that identify efflux pump mediated multi-drug resistant bacteria, characterize efflux systems and screen for inhibitors of efflux pumps. These approaches were complemented by the quantification of the expression of genes that regulate and code for constituents of efflux pumps. The methods described are easy to use,
Viveiros, M +8 more
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Inhibition of Drug Efflux in Mycobacteria with Phenothiazines and Other Putative Efflux Inhibitors
Recent Patents on Anti-Infective Drug Discovery, 2011Mycobacteria are responsible for some of the oldest diseases known to man, usually associated with high morbility and mortality rates. An example is tuberculosis (TB), a major public health problem that accounts for eight million new cases each year. Furthermore, the increase of multidrug and extremely-drug resistance seriously threatens the success of
Liliana, Rodrigues +3 more
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