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Microbial Efflux of Antibiotics and Inhibitors of Efflux Pumps
2014Detergent-like bile salts kill bacterial cells by destroying bacterial multidrug resistance (MDR) efflux systems. These not only play an important role in antibacterial resistance but also contribute to bacterial pathogenesis. Reserpine and H+/K+ ATPase inhibitors can significantly reduce MICs, increase killing activity, and prolong the postantibiotic ...
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Optimized efflux assay for the NorA multidrug efflux pump in Staphylococcus aureus
Journal of Microbiological Methods, 2017Real-time fluorescent efflux assays are commonly used for measuring the efflux of bacterial pumps. Here we describe an optimized protocol for the NorA efflux pump in S. aureus using DiOC3 instead of ethidium bromide. Glucose and sodium formate were tested as energy carriers. This novel method is fast and reproducible.
Saskia, Zimmermann +4 more
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Critical discussion on drug efflux in Mycobacterium tuberculosis
FEMS Microbiology Reviews, 2022Sille Remm +2 more
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Evolution of RND efflux pumps in the development of a successful pathogen
Drug Resistance Updates, 2023Varsha Naidu +2 more
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Function and Inhibitory Mechanisms of Multidrug Efflux Pumps
Frontiers in Microbiology, 2021Kunihiko Nishino +2 more
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Multidrug-resistance efflux pumps ? not just for resistance
Nature Reviews Microbiology, 2006Laura J V Piddock, Piddock Laura J V
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Membrane Cholesterol Efflux Drives Tumor-Associated Macrophage Reprogramming and Tumor Progression
Cell Metabolism, 2019Pieter Goossens +2 more
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Multidrug efflux pumps: structure, function and regulation
Nature Reviews Microbiology, 2018Dijun Du +2 more
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