Results 41 to 50 of about 272,567 (316)
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Minocycline Susceptibility and tetB Gene in Carbapenem-Resistant Acinetobacter baumannii in Taiwan
Infection and Drug Resistance, 2022 Jia-Ling Yang,1 Chia-Jui Yang,2,3 Yu-Chung Chuang,1 Wang-Huei Sheng,1 Yee-Chun Chen,1 Shan-Chwen Chang1 1Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan, Republic of China; 2Department of Internal Medicine, Far ...
Yang JL +5 more
doaj
Journal of Integrative Agriculture, 2016 The objective of this study was to verify the supposition that efflux might be involved in the drug resistance of Riemerella anatipestifer isolates. Two broad-spectrum efflux pump inhibitors, carbonyl cyanide 3-chlorophenylhydrazone (CCCP) and Phe-Arg-β ...
Ya-fei LI +8 more
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Influx, efflux and net uptake of nitrate in Quercus suber seedlings
, 2000 ACESSO via B-on: http://dx.doi.org/doi:10.1023/A:1004785331462Nitrate influx, efflux and net nitrate uptake were measured for the slow-growing Quercus suber L. (cork-oak) to estimate the N-uptake efficiency of its seedlings when grown with free access to
Lambers, H. +9 more
core +1 more source
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
Soil CO2 efflux at timberline on Mt. Fuji
, 2004 P(論文)Soil CO2 effluxes were investigated at timberline on Mt. Fuji. Three study plots along a sequence of vegetation zones (dwarf, tall Japanese larch, and Veitch's silver fir proceeding downward) in the vicinity of timberline were selected for the ...
Masuzawa, Takehiro +2 more
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Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Elucidation of the structure and molecular mechanism of the tripartite multidrug efflux pumps in the Gram-negative pathogens: Vibrio cholerae and Neisseria gonorrhoeae [PDF]
, 2006 In bacteria, multidrug efflux systems have been identified as significant determinants of resistance recently. These resistance pumps are widely distributed in bacterial species and many pathogenic bacteria posses them, which play an important role in ...
Du, Dijun
core
Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis
Molecular Oncology, EarlyView.LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini +1 more
wiley +1 more source
The Daunomycin: Biosynthesis, Actions, and the Search for New Solutions to Enhance Production
MicroorganismsDaunorubicin (DNR) is an anthracycline antibiotic originating from soil-dwelling actinobacteria extensively used to treat malignant tumors. Over the decades, extensive attempts were made to enhance the production of anthracyclines by introducing genetic ...
Baveesh Pudhuvai +7 more
doaj +1 more source