Results 101 to 110 of about 119,180 (205)

Novel 5-oxo-hexahydroquinoline derivatives: design, synthesis, in vitro P-glycoprotein-mediated multidrug resistance reversal profile and molecular dynamics simulation study [PDF]

, 2017
Overexpression of the efflux pump P-glycoprotein (P-gp) is one of the important mechanisms of multidrug resistance (MDR) in many tumor cells. In this study, 26 novel 5-oxo-hexahydroquinoline derivatives containing different nitrophenyl moieties at C-4 ...
Edraki, N., Firuzi, O., Khoshneviszadeh, M., Miri, R., Ranjbar, S., Saso, L., Shahraki, O., Zargari, F.   +7 more
core   +1 more source

Decoding MexB efflux pump genes: structural, molecular, and phylogenetic analysis of multidrug-resistant and extensively drug-resistant Pseudomonas aeruginosa

Frontiers in Cellular and Infection Microbiology
ObjectiveEmerging drug resistance in Pseudomonas aeruginosa is of great concern in clinical settings. P. aeruginosa activates its efflux-pump system in order to evade the effect of antibiotics.
Muhammad Bilal Habib, Naseer Ali Shah, Afreenish Amir, Huda Ahmed Alghamdi, Muhammad Haseeb Tariq, Kiran Nisa, Mariam Ammoun   +6 more
doaj   +1 more source

Baicalin Inhibits Biofilm Formation and the Quorum-Sensing System by Regulating the MsrA Drug Efflux Pump in Staphylococcus saprophyticus

Frontiers in Microbiology, 2019
Staphylococcus saprophyticus (S. saprophyticus) is one of the main pathogens that cause serious infection due to its acquisition of antibiotic resistance.
Jinli Wang, Jinli Wang, Haihong Jiao, Jinwu Meng, Jinwu Meng, Mingyu Qiao, Mingyu Qiao, Hongxu Du, Hongxu Du, Miao He, Miao He, Ke Ming, Ke Ming, Jiaguo Liu, Jiaguo Liu, Deyun Wang, Deyun Wang, Yi Wu, Yi Wu   +18 more
doaj   +1 more source

efflux pump

Citation: 'efflux pump' in the IUPAC Compendium of Chemical Terminology, 5th ed.; International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.12653 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms.
openaire   +1 more source

Chronic Exposure to Triclosan Sustains Microbial Community Shifts and Alters Antibiotic Resistance Gene Levels in Anaerobic Digesters [PDF]

, 2016
Triclosan, an antimicrobial chemical found in consumer personal care products, has been shown to stimulate antibiotic resistance in pathogenic bacteria.
Carey, Daniel Elliott, Choi, Melinda J., Hristova, Krassimira R., Kappell, Anthony D., McNamara, Patrick J., Zitomer, Daniel   +5 more
core   +1 more source

Efflux pumps as antimicrobial resistance mechanisms

Annals of Medicine, 2007
Antibiotic resistance continues to hamper antimicrobial chemotherapy of infectious disease, and while biocide resistance outside of the laboratory is as yet unrealized, in vitro and in vivo episodes of reduced biocide susceptibility are not uncommon.
openaire   +2 more sources

6-gingerol enhances ciprofloxacin efficacy by inhibiting NorA efflux pump in Staphylococcus aureus

The Microbe
The drug efflux mechanism adopted by Staphylococcus aureus helps it in its survival under antibiotic pressure. The efflux pump NorA, a member of the MFS superfamily, effluxes out fluoroquinolones, biocides, quaternary ammonium compounds, and anti ...
Shashikanta Sau, Sarika Sharma, Gopal L. Khatik, Sandeep Sharma, Nitin Pal Kalia   +4 more
doaj   +1 more source

Specificity and tunability of efflux pumps: A new role for the proton gradient?

PLoS Computational Biology
Efflux pumps that transport antibacterial drugs out of bacterial cells have broad specificity, commonly leading to broad spectrum resistance and limiting treatment strategies for infections.
Matthew Gerry, Duncan Kirby, Boian S Alexandrov, Dvira Segal, Anton Zilman   +4 more
doaj   +1 more source

A Mathematical model for Astrocytes mediated LTP at Single Hippocampal Synapses

, 2012
Many contemporary studies have shown that astrocytes play a significant role in modulating both short and long form of synaptic plasticity. There are very few experimental models which elucidate the role of astrocyte over Long-term Potentiation (LTP ...
A Araque, A Destexhe, AG Nikonenko, AL Hodgkin, AM Weber, AM Zhabotinsky, B Katz, B Mouillac, B Sahin, BL Bloodgood, BL Sabatini, BL Sabatini, C Agulhon, C Agulhon, C Fall, C Henneberger, C Koch, CLM Bon, D Dumitriu, D Sochivko, DJ Hagler Jr, DX Keller, E Neher, EB Malarkey, ER Higgins, F Erler, F Helmchen, F Taqatqeh, G Perea, GA Rameau, GL Collingridge, GW Young De, H-K Lee, HJ Koester, HV McCue, I Nikonenko, I Wenker, J Bai, J Boehm, J Garthwaite, J Kang, J Keener, J Lisman, J Marchaland, J Sneyd, J-W Shuai, JA Bibb, JE Lisman, JH Bollmann, JH Bollmann, JT Porter, Kaushik Majumdar, KD Micheva, KG Phillips, KM Franks, KT Blackwell, L-C Ching, L-Y Wang, LC Griffith, M Mazzanti, M Pittà De, M Tsodyks, MS Jafri, N Aslam, NC Danbolt, NJ Emptage, P Bezzi, P Miller, PP Atluri, R Anwyl, R Bertram, R Llinas, R Schneggenburger, R Schneggenburger, R Vargas, RA Hopper, RC Malenka, RF Fox, RP Munton, S Ben Achour, S Nadkarni, S Nadkarni, Shivendra Tewari, SJ Taylor, T Ishikawa, TA Fiacco, TP Jensen, TVP Bliss, TVP Bliss, V Calabrese, V Montana, V Parpura, V Parpura, V Volman, WT Coffey, Y Watanabe, Y-X Li, Z Nusser   +97 more
core   +1 more source

A missing link for efflux pumps

eLife
A lipoprotein called YbjP could be the answer to a puzzle about efflux pumps in gram-negative bacteria.
Hilal Wehbi, Isabelle Broutin
openaire   +1 more source