Results 91 to 100 of about 119,180 (205)

Decreased expression of breast cancer resistance protein in the duodenum in patients with obstructive cholestasis [PDF]

, 2006
Background/Aims: The expression of transporters involved in bile acid homeostasis is differentially regulated during obstructive cholestasis. Since the drug efflux transporter breast cancer resistance protein (BCRP) is known to transport bile acids, we ...
Adachi Y, Brendel C, Christian Zimmermann, Christoph Beglinger, Denk GU, Denson LA, Dietrich CG, Dietrich CG, Ee PL, Frank Lehmann, Freeman LA, Geier A, Gutmann H, Heike Gutmann, Hruz P, Imai Y, Janvilisri T, Jonker JW, Juergen Drewe, Jung D, Jung D, Kamisako T, Klucken J, Li N, Lown KS, Lu TT, Luigi Terracciano, Maliepaard M, Miyake K, Petr Hruz, Plebani M, Popowski K, Schellens JH, Smith M, Stedman CA, Stellaard F, Suzuki M, Taipalensuu J, Tanaka Y, Tanaka Y, Trauner M, Ulrich Beuers, van Herwaarden AE, Volk EL, Wagner M, Xie W, Yu L, Zimmermann C, Zollner G   +48 more
core   +1 more source

Virtual screening and biological activity evaluation of novel efflux pump inhibitors targeting RE-CmeB in Campylobacter spp.

One Health Advances
RE-CmeABC is a variant of the efflux pump CmeABC in the major zoonotic pathogen Campylobacter, which is much more potent in conferring resistance to various antibiotics for the treatment of Campylobacter infections in both veterinary and medical clinics.
Shihong Li, Cheng Zhang, Wenjun Li, Shuigen Wan, Jin Kang, Yong Liu, Hexiang Huang, Hao Li, Longhua Yang, Yanhong Shang, Chenglong Li, Xiangdang Du, Hong Yao   +12 more
doaj   +1 more source

A laboratory method for precisely determining the micro-volume-magnitudes of liquid efflux [PDF]

, 1969
Micro-volumetric quantities of ejected liquid are made to produce equal volumetric displacements of a more dense material. Weight measurements are obtained on the displaced heavier liquid and used to calculate volumes based upon the known density of the ...
Cloutier, R. L.
core   +1 more source

Two Different Tetracycline Resistance Mechanisms, Plasmid-Carried tet(L) and Chromosomally Located Transposon-Associated tet(M), Coexist in Lactobacillus sakei Rits 9 [PDF]

, 2008
Lactobacillus sakei is extensively used as functional starter culture in fermented meat products. One of the safety criteria of a starter culture is the absence of potentially transferable antibiotic resistance determinants.
Ammor, M.S., Danielsen, M., Gueimonde, M., Hoek, A.H.A.M., van, Margolles, A., Mayo, B., Reyes-Gavilán, C.G., de los, Zagorec, M.   +7 more
core   +3 more sources

The effect of carbonyl cyanide m-chlorophenyl-hydrazine on antibiotic susceptibility in MDR Enterobacteriaceae isolates in Babylon, Iraq

Medical Journal of Babylon
Background: One of the efflux pump inhibitors is carbonyl cyanide 3-chlorophenylhydrazone (CCCP) that has often been found to increase the susceptibility of a number of multi-drug resistant (MDR) MDR bacteria, isolated from human clinical specimens ...
Hadeel Qasim Jebur, Alaa H. Al-Charrakh
doaj   +1 more source

Adjuvant Activity and Resistance-Modifying Capacity of a Novel Heterocyclic Hydrazone Derived from the Drug Hydralazine in NorA and MepA Efflux Pumps of Staphylococcus aureus

Drugs and Drug Candidates
Background/Objectives: Hydrazones are organic compounds with the general structure R2C=NNHR1, distinguished by their versatility and modifiability, and are widely used in various applications due to their physicochemical and biological properties.
Milena Oliveira Andrade Moreira, Karla Susanna Tavares Grangeiro Belém, Janaina Esmeraldo Rocha, Davi Ramalho Furtado, Gildenia Alves de Araújo, Ana Joyce Morais Bento, Jessica Bezerra Maciel, Jesyka Macêdo Guedes, Jaiza Maria Lima Dias, Henrique Douglas Melo Coutinho, Francisco das Chagas Lima Pinto, Emmanuel Silva Marinho, Marcia Machado Marinho, Alexandre Magno Rodrigues Teixeira, Walter José Peláez, Hélcio S. dos Santos   +15 more
doaj   +1 more source

Inhibition of MDR1 does not sensitize primitive chronic myeloid leukemia CD34⁺ cells to imatinib [PDF]

, 2009
<p><b>Objective:</b> To investigate the interaction of imatinib mesylate (IM) with the clinically relevant adenosine triphosphate-binding cassette efflux transporter MDR1 (ABCB1) in cells from patients with chronic myeloid leukemia (CML)
Hatziieremia, S., Holyoake, T.L., Jordanides, N.E., Jorgensen, H.G., Mountford, J.C.   +4 more
core   +1 more source

The phenazine pyocyanin is a terminal signalling factor in the quorum sensing network of Pseudomonas aeruginosa [PDF]

, 2006
Certain members of the fluorescent pseudomonads produce and secrete phenazines. These heterocyclic, redox-active compounds are toxic to competing organisms, and the cause of these antibiotic effects has been the focus of intense research efforts.
Dietrich, Lars E. P., Newman, Dianne K., Petersen, Ashley, Price-Whelan, Alexa, Whiteley, Marvin   +4 more
core   +1 more source

Effects of efflux pumps on antifungal activity of chitosan against Candida albicans

Journal of Oral Microbiology
Background Antifungal resistance is a major problem, commonly caused by drug-efflux pump overexpression. To evaluate if chitosan could be effective in drug-resistant Candida infections, we investigated the effects of efflux pumps on antifungal activity ...
Sureeporn Muangsawat, Patcharaporn Chaiyosang, Patrawee Sinkanarak, Juthamas Sukted, Panida Thanyasrisung, Oranart Matangkasombut   +5 more
doaj   +1 more source

Evaluation of the Blue-Carba test for rapid detection of carbapenemases in gram-negative Bacilli [PDF]

, 2015
The Blue-Carba test (BCT) is a biochemical test for rapid (2 h)detection of carbapenemase production in Gram-negative bacillidirectly from bacterial culture .
Albornoz, Ezequiel Pablo, Ceriana, Paola, Corso, Alejandra, Gómez, Sonia Alejandra, Lucero, María Celeste, Pasteran, Fernando, Rapoport, Melina, Veliz, Omar   +7 more
core   +1 more source