Results 71 to 80 of about 71,112 (299)
Function and Inhibitory Mechanisms of Multidrug Efflux Pumps
Frontiers in Microbiology, 2021 Multidrug efflux pumps are inner membrane transporters that export multiple antibiotics from the inside to the outside of bacterial cells, contributing to bacterial multidrug resistance (MDR). Postgenomic analysis has demonstrated that numerous multidrug
Kunihiko Nishino +4 more
doaj +1 more source
Structure of the AcrAB–TolC multidrug efflux pump [PDF]
Nature, 2014 The capacity of numerous bacterial species to tolerate antibiotics and other toxic compounds arises in part from the activity of energy-dependent transporters. In Gram-negative bacteria, many of these transporters form multicomponent 'pumps' that span both inner and outer membranes and are driven energetically by a primary or secondary transporter ...
Du, Dijun +8 more
openaire +2 more sources
Advanced Healthcare Materials, EarlyView.The repair and regeneration of brain tissue faces both biological and technical challenges. Injectable bioscaffolds offer new opportunities to stimulate tissue regrowth in the brain by recruiting neural stem cells. Here, the translational issues are reviewed that need to be address to advance this promising new therapeutic approach from the bench to ...
Michel Modo, Alena Kisel
wiley +1 more source
AntibioticsOne way that bacteria develop antibiotic resistance is by reducing intracellular antibiotic concentrations through efflux pumps. Therefore, enhancing the efficacy of antibiotics using efflux pump inhibitors provides a way to overcome this type of ...
Yena Seo, Minjun Kim, Tae-Jong Kim
doaj +1 more source
Microbial Primer: Multidrug efflux pumps.
Microbiology (Reading, England), 2023 Multidrug efflux pumps are molecular machines that sit in the bacterial cell membrane and pump molecules out from either the periplasm or cytoplasm to outside the cell. While involved in a variety of biological roles, they are primarily known for their contribution to antibiotic resistance by limiting the intracellular accumulation of antimicrobial ...
Siasat, Pauline Ann +1 more
openaire +2 more sources
Bacteria‐Responsive Nanostructured Drug Delivery Systems for Targeted Antimicrobial Therapy
Advanced Materials, EarlyView.Bacteria‐responsive nanocarriers are designed to release antimicrobials only in the presence of infection‐specific cues. This selective activation ensures drug release precisely at the site of infection, avoiding premature or indiscriminate release, and enhancing efficacy.
Guillermo Landa +3 more
wiley +1 more source
Selecting surfactants for the maximum inhibition of the activity of the multidrug resistance efflux pump transporter, P-glycoprotein: conceptual development [PDF]
, 2016 Amphiphilic excipients, such as surfactants, have been shown to be inhibitors of the multidrug resistance (MDR) efflux pump transporter protein, P glycoprotein (Pgp).
Shireesh Apte
core
Advanced Materials, EarlyView.Elephant‐skin‐inspired crack networks are programmed in porous diatomaceous earth (DE)‐cement composites using substrate‐guided, stress‐concentration induced fracture. The resulting crack lattices act as capillary conduits that redistribute water, while the porous matrix stores moisture.
Qingya Huang +5 more
wiley +1 more source
Selecting surfactants for the maximum inhibition of the activity of the multidrug resistance efflux pump transporter, P-glycoprotein: conceptual development [PDF]
, 2010 Amphiphilic excipients, such as surfactants, have been shown to be inhibitors of the multidrug resistance (MDR) efflux pump transporter protein, P glycoprotein (Pgp).
Shireesh Apte
core
Efflux Pump Regulatory Network.
, 2015 Arrows indicate positive regulation. Blunt arrows indicate repression. A) Literature base reconstruction of the AcrAB-TolC efflux pump regulatory network of Escherichia coli as reported on [9].
Maximino Aldana (136867) +2 more
core +1 more source