Results 221 to 230 of about 122,546 (256)
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Antimicrobial Drug Efflux Pump Inhibitors
2016Bacterial multidrug resistance is on the rise, and bacterial efflux pumps make a major contributor to this development. Efflux pump inhibitors (EPIs) may be a solution to this problem, since they can reverse resistance to clinically administered antimicrobial agents. Multiple EPIs with activity against Gram-positive and Gram-negative bacteria have been
Jürgen A. Bohnert, Winfried V. Kern
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Efflux Pumps in Drug Resistance of Candida
Infectious Disorders - Drug Targets, 2006The incidences of human pathogenic yeast Candida albicans and its related species acquiring resistance to antifungals have increased considerably, which poses serious problems towards its successful chemotherapy. The resistance of these pathogenic fungi is not restricted to the commonly used triazole compounds but is even encountered, though not often,
R, Prasad +3 more
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Small Multidrug Resistance Efflux Pumps
2016Small multidrug resistance (SMR) transporters confer resistance to a variety of quaternary cation compound antimicrobials. These secondary active transporters are the smallest known transporters and have been demonstrated to function within the membrane.
Denice C. Bay, Raymond J. Turner
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Efflux pump activity in Enchytraeidae
2019Enchytraeids are ecologically relevant soil organisms, which play an important role in organic matter decomposition and soil bioturbation. They live in close contact with the pore water fraction of soil which makes them vulnerable to xenobiotics exposure.
Hackenberger Kutuzović, Davorka +3 more
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Bacterial efflux pump inhibition.
Current opinion in investigational drugs (London, England : 2000), 2005Drug efflux is recognized as a clinically relevant mechanism of antimicrobial drug resistance in selected species of bacteria. Membrane-based polypeptides belong to distinct protein superfamilies, the members of which are related by structural characteristics, mechanism of action and energy source for the transport process.
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Strategies to Overcome Efflux Pumps
2009Intestinal efflux pumps such as P-glycoprotein play a significant role in altering the absorption of a wide range of drugs. Anticancer agents, antibiotics, antivirals, calcium channel blockers, immunosuppressive agents, peptide drugs and several other therapeutic compounds have been reported to be substrates of one or more transmembrane efflux ...
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Structural basis for channel conduction in the pump-like channelrhodopsin ChRmine
Cell, 2022Yoon Seok Kim +2 more
exaly
Antibiotic resistance and efflux pumps
2019The main purpose of this manuscript is to review the resistance against antibiotics and efflux pumps, one of the mechanisms important in resistance against antibiotics. As a definition, the resistance against antibiotics is accepted as the capability of a microorganism to resist the activity of antimicrobials, which were successfully used to kill the ...
ALTINÖZ, Eda, ALTUNER, Ergin Murat
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Natural Product as Efflux Pump Inhibitors Against MRSA Efflux Pumps: An Update
2022Pallavi Ahirrao +2 more
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