Results 1 to 10 of about 272,567 (316)
Cloning, structural and functional characterization of the ABCB1 transporter of the Eurasian bullfinch (Pyrrhula pyrrhula) [PDF]
Frontiers in Veterinary ScienceSuspected ivermectin hypersensitivity has been reported in the Eurasian bullfinch and some related passerine birds. However, the underlying cause and pharmacological mechanism have not been systematically investigated.
Katharina Heilmann +5 more
doaj +2 more sources
Разработка и регистрация лекарственных средств, 2023 Introduction. Breast cancer resistance protein (BCRP) is an efflux membrane transporter that controls the pharmacokinetics of a large number of drugs. Its activity may change when taking some endo- and exogenous substances, thus making it a link in drug ...
Yu. S. Tranova +7 more
doaj +1 more source
Frontiers in Microbiology, 2022 Quaternary ammonium compounds (QACs) are widely used as active agents in disinfectants, antiseptics, and preservatives. Despite being in use since the 1940s, there remain multiple open questions regarding their detailed mode-of-action and the mechanisms,
Niclas Nordholt +6 more
doaj +1 more source
Cholesterol Efflux Assay [PDF]
Journal of Visualized Experiments, 2012 Cholesterol content of cells must be maintained within the very tight limits, too much or too little cholesterol in a cell results in disruption of cellular membranes, apoptosis and necrosis. Cells can source cholesterol from intracellular synthesis and from plasma lipoproteins, both sources are sufficient to fully satisfy cells' requirements for ...
Hann, Low, Anh, Hoang, Dmitri, Sviridov
openaire +2 more sources
Consideration of Metabolite Efflux in Radiolabelled Choline Kinetics
Pharmaceutics, 2021 Hypoxia is a complex microenvironmental condition known to regulate choline kinase α (CHKA) activity and choline transport through transcription factor hypoxia-inducible factor-1α (HIF-1α) and, therefore, may confound the uptake of choline radiotracer ...
Yunqing Li +14 more
doaj +1 more source
The MexJK Efflux Pump of Pseudomonas aeruginosa Requires OprM for Antibiotic Efflux but Not for Efflux of Triclosan [PDF]
Journal of Bacteriology, 2002 ABSTRACT Using the biocide triclosan as a selective agent, several triclosan-resistant mutants of a susceptible Pseudomonas aeruginosa strain were isolated. Cloning and characterization of a DNA fragment conferring triclosan resistance from one of these mutants revealed a hitherto uncharacterized efflux ...
Rungtip, Chuanchuen +2 more
openaire +2 more sources
Targeted cholesterol efflux [PDF]
Cell Cycle, 2013 In the process of reverse cholesterol transport, high-density lipoprotein (HDL) transports excess cholesterol from peripheral cells back to the liver, where cholesterol is recycled or metabolized and excreted. On the cellular level, 2 membrane-associated ATP-binding cassette (ABC) cholesterol transporters, ABCA1 and ABCG1, play a major role in ...
Fang, Longhou, Miller, Yury I
openaire +2 more sources
Frontiers in Microbiology, 2018 The Burkholderia cenocepacia epidemic ET12 lineage belongs to the genomovar IIIA including the reference strain J2315, a highly transmissible epidemic B. cenocepacia lineage.
Josselin Bodilis +6 more
doaj +1 more source
mBio, 2020 This research analyzed six Aspergillus fumigatus genes encoding putative efflux proteins for their roles as transporters. The A. fumigatus genes abcA, abcC, abcF, abcG, abcH, and abcI were cloned into plasmids and overexpressed in a Saccharomyces ...
Brooke D. Esquivel +5 more
doaj +1 more source
Multidrug Efflux Pumps in Bacteria and Efflux Pump Inhibitors
Postępy Mikrobiologii - Advancements of Microbiology, 2022 Abstract Antimicrobial resistance is becoming a paramount health concern nowadays. The increasing drug resistance in microbes is due to improper medications or over usage of drugs. Bacteria develop many mechanisms to extrude the antibiotics entering the cell. The most prominent are the efflux pumps (EPs).
Sreekantan Abhirami P. +3 more
openaire +2 more sources