Results 141 to 150 of about 985,633 (279)

Molecular mechanism of transition-state inhibitors of bacterial antibiotic efflux pumps. [PDF]

NPJ Antimicrob Resist
Börnsen C, Müller RT, Vieira Da Cruz A, Jiménez-Castellanos JC, Meurillon V, Brandstätter L, Lodinsky EV, Athar M, Vargiu AV, Hartkoorn RC, Flipo M, Frangakis AS, Pos KM.   +12 more
europepmc   +1 more source

Programmable Paracrine‐Mimetic Microneedle System for Temporal Regulation of Cardiac Repair

Advanced Science, EarlyView.
Temporal signaling is encoded into a programmable paracrine‐mimetic microneedle patch via tris(2,2'‐bipyridyl)dichlororuthenium(II) hexahydrate/sodium persulfate‐tuned hydrogel microparticles that deliver TGF‐β, IGF‐1, and VEGF over phase‐matched 7‐, 14‐, and 28‐day windows.
Yichen Dai, Pengchong Du, Zhaoyang Wang, Surilige, Rangga Fokta, Renjian Tan, Xiqing Zhao, Shuoyi Zhang, Yuecheng Wang, Yixin Zhang, Ziliang Fu, Rui Gong, Cheng Jiang, Yisheng He, Qiguang Wang, Renke Li, Khoon Lim, Junnan Tang, Xiaolin Cui   +18 more
wiley   +1 more source

Cryo-EM reveals the structural heterogeneity and conformational flexibility of multidrug efflux pumps MdtB and MdtF. [PDF]

mBio
Padmanaban S, Rencilin CF, Biswas R, Dutta S.   +3 more
europepmc   +2 more sources

Efflux pumps control intracellular drug-target kinetics by limiting rebinding in bacteria. [PDF]

Sci Adv
Dev S, Stevenson K, Le D, Kim M.
europepmc   +1 more source

Tailored Covalent Organic Frameworks Enable the Encapsulation of Living Cells to Produce Rare Ginsenoside

Advanced Science, EarlyView.
This work reports the in situ fabrication of Escherichia coli@covalent organic frameworks (E. coli@COFs) in phosphate‐buffered saline. The COFs form an exoskeleton on E. coli, protecting intracellular β‐glucosidase (Ssbgl) while enhancing mass transfer.
Fengmei Liu, Shan Zhang, Shanrong Wei, Ziye Xing, Hongming He, Xiao Liang, Quanshun Li   +6 more
wiley   +1 more source

CRISPR-based genome editing reveals the roles of efflux pumps in <i>Mycobacterium abscessus</i>. [PDF]

mLife
Li S, Duan A, Zhang L, Wang C, Yan M, Ren GX, Pan LP, Sun YC.   +7 more
europepmc   +1 more source

Convergence of Plasmid‐Mediated tmexCD‐toprJ With Critical Resistance Genes Fuels Spread of Multidrug Resistant Bacteria

Advanced Science, EarlyView.
Global dissemination of tmexCD‐toprJ across bacterial hosts and ecological niches is accompanied by its convergence with blaKPC, blaNDM, and mcr on mobile plasmids. Recombination and acquisition of resistance modules generate distinct multidrug resistant plasmid architectures, facilitating the emergence and spread of high‐risk bacterial populations ...
Kaiwen Song, Meng Wang, Xingyu Wu, Meng Cai, Bowen Li, Qi Wang, Xiaodong Guan, Qi Ding, Ruobing Wang, Hui Wang   +9 more
wiley   +1 more source

Multidrug efflux pumps and innate azole resistance of Mucor lusitanicus. [PDF]

J Antimicrob Chemother
Toepfer S, Lamping E, James JE, Zenz LM, Loacker-Schoech J, Rosam K, Majer O, Lackner M.   +7 more
europepmc   +1 more source

Engineering CAR‐Macrophages With Advanced Delivery Systems for Tissue Repair

Advanced Science, EarlyView.
This review highlights how engineered macrophages equipped with chimeric antigen receptors (CAR) guide tissue repair by recognizing disease‐related targets, clearing harmful cells, and reshaping local immune environments. It summarizes macrophage biology, CAR design, delivery platforms, and functionalization strategies, and discusses emerging ...
Yixin Zhang, Jintian Yu, Liang Yuan, Ziliang Fu, Yiming Yao, Lingna Chen, Shixiong Chen, Aikemu Ainiwaer, Xiaolin Cui   +8 more
wiley   +1 more source

Inhibition of prolyl-tRNA synthetase and efflux pumps as a dual-targeting strategy against multidrug-resistant bacteria. [PDF]

J Enzyme Inhib Med Chem
Tambascia C, Silva JC, Dos Reis BC, Camilo CFS, Tairum Junior CA, Hancio T, Correia VG, Pilli RA, de Godoy AS, Laleu B, Sforça ML, Rocco SA, Benedetti CE, Mercaldi GF.   +13 more
europepmc   +1 more source