Results 51 to 60 of about 50,413 (250)

Determination of efflux activity in Enterococci by Hoechst accumulation assay and the role of zinc oxide nanoparticles in inhibition of this activity

BMC Microbiology, 2022
Background Contribution of efflux pumps in development of antimicrobial resistance has been largely addressed in Gram negative and to a much lesser extent in Gram positive bacteria.
Mohammad Hossein Sobhanipoor, Roya Ahmadrajabi, Hossein Hosseini Nave, Fereshteh Saffari   +3 more
doaj   +1 more source

The culmination of multidrug-resistant efflux pumps vs. meager antibiotic arsenal era: Urgent need for an improved new generation of EPIs

Frontiers in Microbiology, 2023
Efflux pumps function as an advanced defense system against antimicrobials by reducing the concentration of drugs inside the bacteria and extruding the substances outside. Various extraneous substances, including antimicrobials, toxic heavy metals, dyes,
Shiela Chetri
doaj   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Fusogenic RNA Nanomodules for Fusion‐Mediated and Multiplexed siRNA Delivery

Advanced Functional Materials, EarlyView.
A fusogenic lipid‐layered RNA nanomodules (L‐CRAMs) enable high‐capacity and long‐lasting siRNA delivery through membrane fusion. These nanomodules carry exceptionally large siRNA payloads, avoid conventional endosomal uptake, and release multiple functional siRNAs through Dicer‐mediated processing.
Sunghyun Moon, Iksoo Jang, Taehyeon Kim, Nayoung Yoon, Kyuha Yum, Jong Bum Lee   +5 more
wiley   +1 more source

Beyond Antimicrobial Resistance: Evidence for a Distinct Role of the AcrD Efflux Pump in Salmonella Biology

mBio, 2016
For over 20 years, bacterial multidrug resistance (MDR) efflux pumps have been studied because of their impact on resistance to antimicrobials. However, critical questions remain, including why produce efflux pumps under non-antimicrobial treatment ...
Michelle M. C. Buckner, Jessica M. A. Blair, Roberto M. La Ragione, Jane Newcombe, Daniel J. Dwyer, Alasdair Ivens, Laura J. V. Piddock   +6 more
doaj   +1 more source

Interplay between three RND efflux pumps in doxycycline-selected strains of Burkholderia thailandensis. [PDF]

PLoS ONE, 2013
BACKGROUND: Efflux systems are involved in multidrug resistance in most Gram-negative non-fermentative bacteria. We have chosen Burkholderia thailandensis to dissect the development of multidrug resistance phenotypes under antibiotic pressure ...
Fabrice Vincent Biot, Mélanie Monique Lopez, Thomas Poyot, Fabienne Neulat-Ripoll, Sabrina Lignon, Arnaud Caclard, François Michel Thibault, Andre Peinnequin, Jean-Marie Pagès, Eric Valade   +9 more
doaj   +1 more source

Contribution of RND-Type Efflux Pumps in Reduced Susceptibility to Biocides in Acinetobacter baumannii

Antibiotics, 2022
Bacterial efflux pumps are among the key mechanisms of resistance against antibiotics and biocides. We investigated whether differential expression levels of the RND-type efflux pumps AdeABC and AdeIJK impacted the susceptibility to commonly used ...
Christina Meyer, Kai Lucaβen, Stefanie Gerson, Kyriaki Xanthopoulou, Thorsten Wille, Harald Seifert, Paul G. Higgins   +6 more
doaj   +1 more source

A Novel Modified Petroresin Particle (MPRP) With Enhanced Oil–Water Selectivity for Cold Production in Heavy Oil Reservoirs

Advanced Functional Materials, EarlyView.
A novel oil–water selective conformance control agent, MPRP, is prepared via hydrophilic grafting and mechanical granulation. MPRP uniformly disperses in water, cohesively expands upon aging, and readily dissolves in the oil phase. During conformance control, it selectively aggregates in water channeling pathways to form effective plugs without ...
Guang Zhao, Dongfang Lv, Chang Liu, Changxu Wu, Yifei Liu, Caili Dai, Huazhou Li   +6 more
wiley   +1 more source

Clinical Status of Efflux Resistance Mechanisms in Gram-Negative Bacteria

Antibiotics, 2021
Antibiotic efflux is a mechanism that is well-documented in the phenotype of multidrug resistance in bacteria. Efflux is considered as an early facilitating mechanism in the bacterial adaptation face to the concentration of antibiotics at the infectious ...
Anne Davin-Regli, Jean-Marie Pages, Aurélie Ferrand   +2 more
doaj   +1 more source

Efflux pump-mediated resistance in chemotherapy

Annals of Medical and Health Sciences Research, 2012
Efflux pump mechanisms perform important physiological functions such as prevention of toxin absorption from the gastrointestinal tract, elimination of bile from the hepatocytes, effective functioning of the blood-brain barrier and placental barrier, and renal excretion of drugs.
Ughachukwu, PO, Unekwe, PC
openaire   +4 more sources