Results 171 to 180 of about 180,666 (287)

YTHDC1 Orchestrates Glucose and Glutamate Rewiring to Overcome Lethal Metabolic Stress in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
Lai et al. find that m6A reader YTHDC1 is specifically overexpressed in triple‐negative breast cancer (TNBC) and orchestrates glucose and glutamine metabolism in an m6A‐dependent manner to confer robust adaptability to lethal metabolic stress. Leveraging YTHDC1 knockdown‐induced metabolic vulnerability, an ATF4 mRNA‐targeted nanotherapy is developed to
Zheng‐Hao Lai, Yi Wang, Na‐Na Li, Ling Zeng, Renzhong Liu, Xue Li, Cheukfai Li, Xin‐Yu Ma, Wenkui Fu, Yingsen Tang, Jinjin Chen, Ning Liao, Man‐Li Luo   +12 more
wiley   +1 more source

Inhibition of prolyl-tRNA synthetase and efflux pumps as a dual-targeting strategy against multidrug-resistant bacteria. [PDF]

J Enzyme Inhib Med Chem
Tambascia C, Silva JC, Dos Reis BC, Camilo CFS, Tairum Junior CA, Hancio T, Correia VG, Pilli RA, de Godoy AS, Laleu B, Sforça ML, Rocco SA, Benedetti CE, Mercaldi GF.   +13 more
europepmc   +1 more source

Mitochondria‐Targeted Multimodal Nanotherapeutics Suppress Oxidized mtDNA‐Driven Inflammation at the Source

Advanced Science, EarlyView.
Ox‐mtDNA fragments escaping from mitochondria drive robust inflammatory responses. A targeted nanoplatform simultaneously inhibits mitochondrial FEN1‐mediated mtDNA cleavage and scavenges ROS, preventing the generation of immunogenic Ox‐mtDNA fragments. The released SeNPs further promote autophagic clearance of cytosolic mtDNA. Consequently, cGAS‐STING,
Wen‐Ling Li, Juan Cao, Yu‐Lin Wang, Yu‐Han Fan, Jia‐Qi Xu, Xian Wu Cheng, Lei Xing, Hu‐Lin Jiang   +7 more
wiley   +1 more source

Beyond antibiotic resistance: evidence for resistance-nodulation-division (RND) efflux pumps as virulence determinants. [PDF]

Microbiol Mol Biol Rev
Detweiler CS, Alav I.
europepmc   +1 more source

A Compact Hollow Fiber Electrode Assembly Architecture for Continuous Electrochemical Marine Carbon Dioxide Removal

Advanced Energy Materials, EarlyView.
A coaxial, membrane‐integrated hollow fiber electrode assembly (HFEA) is developed for continuous marine carbon mineralization. By utilizing a sub‐millimeter inter‐electrode gap, the HFEA minimizes Ohmic losses, achieving 50% energy reduction and over 85% DIC removal.
Inhwan Park, Young Hun Lee, Jung Hun Lee, Seung‐Jeong Oh, T. Alan Hatton, Dong‐Yeun Koh   +5 more
wiley   +1 more source

Understanding the contribution of Resistance-Nodulation-Division family efflux pumps to the lifestyle of Pseudomonas aeruginosa [PDF]

Resistance-Nodulation-Division (RND) family efflux pumps are important antibiotic resistance determinants that extrude a range of structurally diverse antibiotics from the cell before they reach their target.
Scales, Danielle
core  

Heavy Metal Contamination: Impacts From Plants to the Food Chain and Eco‐Friendly Amelioration Strategies

AgriFood: Journal of Agricultural Products for Food, EarlyView.
Heavy metal pollution reduces soil health and threatens food safety by entering plants; however, the use of nanoparticles, biofertilizers, and organic fertilizers such as biochar offers a promising strategy for improvement and sustainable agriculture. ABSTRACT Heavy metal (HM) pollution, resulting from human activities such as mining and the excessive ...
Sina Siavash Moghaddam, Latifeh Pourakbar, Sevda Alizadeh, Zahra Alizadeh, Jelena Popović‐Djordjević   +4 more
wiley   +1 more source

Evaluation of Novel Benzo-Annelated 1,4-Dihydropyridines as Potential Inhibitors of Antibacterial Efflux Pumps in <i>S. aureus</i> and MRSA Strains. [PDF]

Int J Mol Sci
Werner P, Szemerédi N, Spengler G, Erdmann F, Hilgeroth A.   +4 more
europepmc   +1 more source

Chinese Expert Consensus on the Clinical Application of Finerenone in Geriatric Comorbidities

AGING MEDICINE, EarlyView.
Mineralocorticoid receptor (MR) overactivation drives inflammation, oxidative stress, and fibrosis in the heart, kidneys, and vasculature, leading to cardiorenal dysfunction. MR signaling promotes hypertrophy, remodeling, and injury through pathways like oxidative stress and inflammation, resulting in vascular stiffness and progressive organ damage ...
Xiaoming Wang, Cuntai Zhang
wiley   +1 more source

Imipenem-Induced Transcriptional Responses of Porin, Efflux Pumps, and Carbapenemase Genes in Clinical Carbapenem-Resistant <i>Acinetobacter baumannii</i>. [PDF]

Antibiotics (Basel)
Rizvanoglu SS, Karaca B, Eryilmaz M.
europepmc   +1 more source