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Efflux pumps as potential targets for biofilm inhibition [PDF]
Frontiers in MicrobiologyBiofilms account for a great deal of infectious diseases and contribute significantly to antimicrobial resistance. Efflux pumps confer antimicrobial resistance to microorganisms and involve multiple processes of biofilm formation. Efflux pump inhibitors (
Jingyi Ren +3 more
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Efflux pumps and microbial biofilm formation
Infection, Genetics and Evolution, 2023 Biofilm-related infections are resistant forms of pathogens that are regarded as a medical problem, particularly due to the spread of multiple drug resistance. One of the factors associated with biofilm drug resistance is the presence of various types of efflux pumps in bacteria.
Kafil Hs
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Effects of efflux pumps on antifungal activity of chitosan against Candida albicans [PDF]
Journal of Oral MicrobiologyBackground Antifungal resistance is a major problem, commonly caused by drug-efflux pump overexpression. To evaluate if chitosan could be effective in drug-resistant Candida infections, we investigated the effects of efflux pumps on antifungal activity ...
Sureeporn Muangsawat +5 more
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Efflux pumps mediate changes to fundamental bacterial physiology via membrane potential [PDF]
mBioEfflux pumps are well known to be an important mechanism for removing noxious substances such as antibiotics from bacteria. Given that many antibiotics function by accumulating inside bacteria, efflux pumps contribute to resistance.
Emily E. Whittle +6 more
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Multidrug Efflux Pumps in Bacteria and Efflux Pump Inhibitors
Postępy Mikrobiologii - Advancements of Microbiology, 2022 Abstract Antimicrobial resistance is becoming a paramount health concern nowadays. The increasing drug resistance in microbes is due to improper medications or over usage of drugs. Bacteria develop many mechanisms to extrude the antibiotics entering the cell. The most prominent are the efflux pumps (EPs).
Sreekantan Abhirami P. +3 more
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EFFLUX PUMPS AS A PHARMACOLOGICAL TARGET TO COMBAT ANTIBIOTIC RESISTANCE
Медична наука України, 2023 Backround. Antibiotic resistance is the resistance of bacteria to antimicrobial drugs to which they were previously sensitive. A particular danger is the spread of multidrug-resistant healthcare-associated infections of "ESKAPE" group.
M.V. Khaitovych
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PLoS Biology, 2022 Bacteria have membrane-spanning efflux pumps to secrete toxic compounds ranging from heavy metal ions to organic chemicals, including antibiotic drugs.
Christopher J Stubenrauch +3 more
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Susceptibility Tests and Predictions of Transporter Profile in Serratia Species
Microorganisms, 2022 Disinfectants and biosecurity are critically important to control microbial diseases. Resistance to disinfectants compromises sectors such as agriculture and healthcare systems.
Gunther J. Staats +3 more
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Role of efflux pumps, their inhibitors, and regulators in colistin resistance
Frontiers in Microbiology, 2023 Colistin is highly promising against multidrug-resistant and extensively drug-resistant bacteria clinically. Bacteria are resistant to colistin mainly through mcr and chromosome-mediated lipopolysaccharide (LPS) synthesis-related locus variation. However,
Yinhuan Ding +9 more
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mSystems, 2021 Multidrug resistance (MDR) efflux pumps are involved in bacterial intrinsic resistance to multiple antimicrobials. Expression of MDR efflux pumps can be either constitutive or transiently induced by various environmental signals, which are typically ...
Di-Yin Li +7 more
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