Results 31 to 40 of about 985,633 (279)
Update on Multidrug Resistance Efflux Pumps in Acinetobacter spp.
Antimicrobial Agents and Chemotherapy, 2021 Acinetobacter spp. have become of increased clinical importance as studies have shown the antimicrobial resistant potential of these species. Efflux pumps can lead to reduced susceptibility to a variety of antibiotics and are present in large number ...
Vanessa Kornelsen, Ayush Kumar
semanticscholar +1 more source
Multidrug efflux pumps at the crossroad between antibiotic resistance and bacterial virulence
Frontiers in Microbiology, 2016 Multidrug efflux pumps can be involved in bacterial resistance to antibiotics at different levels. Some efflux pumps are constitutively expressed at low levels and contribute to intrinsic resistance.
Manuel Alcalde-Rico +3 more
doaj +1 more source
Nanoscale Research Letters, 2017 The universal problem of bacterial resistance to antibiotic reflects a serious threat for physicians to control infections. Evolution in bacteria results in the development of various complex resistance mechanisms to neutralize the bactericidal effect of
Divya Gupta, Ajeet Singh, Asad U. Khan
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Evaluation of Delafloxacin against a Burkholderia pseudomallei Efflux Mutant Panel
Microbiology Spectrum, 2022 In vitro activities of delafloxacin and ciprofloxacin were evaluated against Burkholderia pseudomallei mutants expressing or lacking defined resistance-nodulation-cell division (RND) efflux pumps using CLSI methodology at pHs of 5.8 and 7.2. Delafloxacin
Sandra P. McCurdy +2 more
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Frontiers in Molecular Biosciences, 2021 Bacterial pathogens are able to survive within diverse habitats. The dynamic adaptation to the surroundings depends on their ability to sense environmental variations and to respond in an appropriate manner. This involves, among others, the activation of
M. Pasqua +8 more
semanticscholar +1 more source
Antibiotics, 2023 The aim of this work was to (i) evaluate the efficacy of a combination treatment of pentamidine with ciprofloxacin against Galleria mellonella larvae infected with an MDR strain of P.
Megan Fletcher +3 more
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Versatility of Stenotrophomonas maltophilia: Ecological roles of RND efflux pumps
Heliyon, 2023 S. maltophilia is a widely distributed bacterium found in natural, anthropized and clinical environments. The genome of this opportunistic pathogen of environmental origin includes a large number of genes encoding RND efflux pumps independently of the ...
Amandine Chauviat +2 more
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Revisiting the role of efflux pumps in multidrug-resistant cancer
Nature Reviews. Cancer, 2018 Most patients who die of cancer have disseminated disease that has become resistant to multiple therapeutic modalities. Ample evidence suggests that the expression of ATP-binding cassette (ABC) transporters, especially the multidrug resistance protein 1 (
R. Robey +5 more
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Multidrug Efflux Pumps and the Two-Faced Janus of Substrates and Inhibitors
Accounts of Chemical Research, 2021 CONSPECTUS: Antibiotics are miracle drugs that can cure infectious bacterial diseases. However, their utility is challenged by antibiotic-resistant bacteria emerging in clinics and straining modern medicine and our ways of life.
H. Zgurskaya +3 more
semanticscholar +1 more source
Detection of tetracyclines and efflux pump inhibitors [PDF]
Antimicrobial Agents and Chemotherapy, 1993 Screening assays for the detection of tetracyclines and inhibitors of tetracycline efflux pumps are described. The tetracycline assay is based on the observation that the tetA(B) gene encoding the efflux pump of transposon Tn10 is induced by tetracycline.
D M, Rothstein +6 more
openaire +2 more sources