Results 131 to 140 of about 180,666 (287)

Identification and characterisation of two functional antibiotic MATE efflux pumps in the archaeon Halorubrum amylolyticum

npj Antimicrobials and Resistance
Multidrug efflux pumps have been found to play a crucial role in drug resistance in bacteria and eukaryotes. In this study, we investigated the presence of functional multidrug and toxic compound extrusion (MATE) efflux pumps, inferred from whole genome ...
Asma A. Fakhoury, Thomas P. Thompson, Khondaker Miraz Rahman, Julianne Megaw, Matthew I. McAteer, Timofey Skvortsov, Stephen A. Kelly, Brendan F. Gilmore   +7 more
doaj   +1 more source

Identification of three outer membrane channels of RND efflux pumps.

, 2013
Identification of three outer membrane channels of RND efflux pumps.
Thomas Poyot (135820), Andre Peinnequin (5657299), Jean-Marie Pagès (69129), Arnaud Caclard (502569), François Michel Thibault (502570), Mélanie Monique Lopez (502567), Eric Valade (356355), Fabienne Neulat-Ripoll (502568), Fabrice Vincent Biot (502566), Sabrina Lignon (258760)   +9 more
core   +1 more source

ABCABC Stacking‐Enabled Non‐Centrosymmetry 3R‐ZnIn2S4 Nanosheets for Piezocatalytic Uranium Extraction

Advanced Science, EarlyView.
The ABCABC stacking sequence in 2D ZnIn2S4 nanosheets creates intrinsic non‐centrosymmetry, enabling robust piezocatalysis under weak mechanical agitation. The nanosheets achieve a H2O2 yield of 276.7 µmol g−1 h−1 and uranium extraction capacity of 763.2 mg g−1 via a dual mechanism of direct piezoreduction and in situ H2O2 complexation.
Song Li, Huaijuan Zhou, Yingting Yang, Yanhong Lv, Zdeněk Sofer, Jianyun Zheng, Jinhua Li   +6 more
wiley   +1 more source

A Programmable Calcification Nanoplatform for Loco‐Regional Calcification‐Immune Hepatocellular Carcinoma Therapy

Advanced Science, EarlyView.
An in situ‐grown BP‐CaO2 nanoplatform supplies coordinated Ca2+, endogenous phosphate, and oxidative stress to convert tumor calcification from a passive endpoint into an active immune‐remodeling process. Widespread hydroxyapatite deposition is visualized by CT, while multi‐omics reveals MCOLN2 as a calcium‐responsive mediator linking biomineralization
Long Liu, Peng Li, Zhixiang Lu, Shuqin Xu, Juanjuan Wang, Kai Ma, Haodong Yu, Can Zhou, Hu Chen, Gang Liu, Yi Lyu, Shuang Bai   +11 more
wiley   +1 more source

Reversing Temozolomide Resistance in Glioblastoma Based on Cuproptosis‐Mediated Positive Feedback Loop

Advanced Science, EarlyView.
To effectively reverse TMZ resistance, this work proposes a cuproptosis‐mediated positive feedback loop that integrates mitochondrial dysfunction, ATP depletion, AMPK‐p53 signaling, and glycolytic inhibition, ultimately amplifying cell death. This cuproptosis‐mediated feedback loop simultaneously disrupts multiple resistance pathways in GBM, including ...
Wenjie Feng, Rui Yang, Chang Weng, Chen Li, Wanrui Shi, Yang Chen, Yang Yang, Yi Liu, Pengfei Ge, Hao Zhang   +9 more
wiley   +1 more source

Pyrazole‐Derived Antibacterial Compounds Effectively Treat Methicillin‐Resistant Staphylococcus Aureus Infections by Inhibiting Aspartate Transcarbamoylase

Advanced Science, EarlyView.
This study unveils a novel antibacterial mechanism against MRSA, in which the compound Py‐27 selectively targets and inhibits aspartate transcarbamoylase (ATCase), a key enzyme in pyrimidine synthesis. This inhibition disrupts DNA replication, induces oxidative damage, leading to potent bactericidal activity.
Xiaorong Yang, Xinyuan Cao, Lixia Dai, Feng Yang, Jing Wang, Yudong Ma, Tong Bu, Zile Gong, Xueyan Liu, Changcai Bai, Xiaolou Miao, Xiaofei Shang   +11 more
wiley   +1 more source

Bacterial antibiotic resistance by efflux pumps [PDF]

, 2011
La resistencia a los antimicrobianos representa un severo problema a nivel mundial. Se han descripto variados mecanismos de resistencia, entre los cuales se encuentran las bombas de eflujo.
Errecalde, Jorge Oscar, Marchetti, María Laura, Mestorino, Olga Nora   +2 more
core  

Efflux Pumps Role in the Emergence of MDR Bacteria [PDF]

       The emergence multidrug tolerance is the most threatening obstacle for the population health.  During the last years, transporting pumps are implicated in the emergence of antibiotic resistance.
Jabuk, Sura I.A., Al-Taee , Zahraa M., Ridha , Dalal M., AL-Rafyai , Hawraa M.   +3 more
core   +1 more source

Asymmetric Single‐Atom Catalysts Govern Diffusible and Non‐Diffusible Non‐Radical Pathways for Selective Degradation of Antibiotic Resistance Genes

Advanced Science, EarlyView.
Asymmetric single‐atom metal‐nitrogen‐carbon catalysts modulate the non‐radical pathway during peroxymonosulfate (PMS) activation. A fundamental contrast was revealed between diffusible singlet oxygen (1O2) and non‐diffusible electron‐transfer pathways (ETP) in antibiotic resistance gene (ARG) degradation.
Chen Gao, Jun Sun, Liang Zhang, Litao Lin, Zongfeng Wan, Bingcai Pan, Sheng Tang   +6 more
wiley   +1 more source

Understanding the role of multidrug efflux pumps in Shigella

, 2018
The efflux pumps represent an important and consistent group of proteins involved in transport process present in all living cells. The importance of efflux pumps in bacteria has always been associated to their ability to extrude a wide range of ...
Milena Grossi, Sara Scinicariello, Bianca Colonna, Laurent Aussel, Gianni Prosseda, Martina Pasqua, Frederic Barras   +6 more
core