Results 11 to 20 of about 54,202 (287)
Versatility of Stenotrophomonas maltophilia: Ecological roles of RND efflux pumps
Heliyon, 2023 S. maltophilia is a widely distributed bacterium found in natural, anthropized and clinical environments. The genome of this opportunistic pathogen of environmental origin includes a large number of genes encoding RND efflux pumps independently of the ...
Amandine Chauviat +2 more
doaj +2 more sources
Antibiotics, 2023 Pseudomonas aeruginosa (P. aeruginosa) poses a grave clinical challenge due to its multidrug resistance (MDR) phenotype, leading to severe and life-threatening infections.
Asiyeh Avakh +4 more
doaj +2 more sources
Microbial Primer: Multidrug efflux pumps. [PDF]
Microbiology (Reading, England), 2023 Multidrug efflux pumps are molecular machines that sit in the bacterial cell membrane and pump molecules out from either the periplasm or cytoplasm to outside the cell. While involved in a variety of biological roles, they are primarily known for their contribution to antibiotic resistance by limiting the intracellular accumulation of antimicrobial ...
Siasat, Pauline Ann +1 more
openaire +3 more sources
Efflux pumps as potential targets for biofilm inhibition [PDF]
Frontiers in MicrobiologyBiofilms account for a great deal of infectious diseases and contribute significantly to antimicrobial resistance. Efflux pumps confer antimicrobial resistance to microorganisms and involve multiple processes of biofilm formation. Efflux pump inhibitors (
Jingyi Ren +3 more
doaj +2 more sources
Efflux pumps and microbial biofilm formation
Infection, Genetics and Evolution, 2023 Biofilm-related infections are resistant forms of pathogens that are regarded as a medical problem, particularly due to the spread of multiple drug resistance. One of the factors associated with biofilm drug resistance is the presence of various types of efflux pumps in bacteria.
Hossein Samadi Kafil
exaly +3 more sources
A missing link for efflux pumps. [PDF]
ElifeA lipoprotein called YbjP could be the answer to a puzzle about efflux pumps in gram-negative bacteria.
Wehbi H, Broutin I.
europepmc +2 more sources
Biochemistry of Bacterial Multidrug Efflux Pumps [PDF]
International Journal of Molecular Sciences, 2012 Bacterial pathogens that are multi-drug resistant compromise the effectiveness of treatment when they are the causative agents of infectious disease. These multi-drug resistance mechanisms allow bacteria to survive in the presence of clinically useful antimicrobial agents, thus reducing the efficacy of chemotherapy towards infectious disease ...
Kumar, Sanath, Varela, Manuel F.
openaire +3 more sources
Inhibitors of bacterial efflux pumps that also inhibit efflux pumps of cancer cells. [PDF]
Anticancer research, 2012 Bacteria and cancer cells frequently increase their resistance to chemotherapeutics as a consequence of therapy. Whenever studied, refractory response to chemotherapy is due to the over-expression of efflux pumps that render the bacterium or cancer cell resistant not only to the agent used for therapy, but to many, if not all other agents as well ...
Amaral, Leonard +6 more
openaire +3 more sources
Effects of efflux pumps on antifungal activity of chitosan against Candida albicans [PDF]
Journal of Oral MicrobiologyBackground Antifungal resistance is a major problem, commonly caused by drug-efflux pump overexpression. To evaluate if chitosan could be effective in drug-resistant Candida infections, we investigated the effects of efflux pumps on antifungal activity ...
Sureeporn Muangsawat +5 more
doaj +2 more sources
Efflux pumps mediate changes to fundamental bacterial physiology via membrane potential [PDF]
mBioEfflux pumps are well known to be an important mechanism for removing noxious substances such as antibiotics from bacteria. Given that many antibiotics function by accumulating inside bacteria, efflux pumps contribute to resistance.
Emily E. Whittle +6 more
doaj +2 more sources