Results 191 to 200 of about 180,666 (287)

A Modular Synthesis of C5‐Sulfenyl Thiazoles via an Intermolecular Pummerer Rearrangement: An Underexplored Scaffold for Medicinal Chemistry

Angewandte Chemie, EarlyView.
Modular access to underexplored C5‐sulfenyl thiazoles via an intermolecular Pummerer rearrangement is reported. The methodology exhibits a broad functional group tolerance enabling the seamless design of trisubstituted thiazole cores bearing a sulfur handle for further elaboration.
Joe L. Smy, Theo C. Webb, Barnaby W. Greenland, S. Mark Roe, John Spencer, Storm Hassell‐Hart   +5 more
wiley   +2 more sources

Antibacterial Activity of Extract, Fractions, and Compounds from <i>Termitomyces clypeatus</i> R. Heim (Lyophyllaceae) Against Multidrug-Resistant Bacteria Overexpressing Efflux Pumps. [PDF]

Pharmaceuticals (Basel)
Kuete JRN, Kuete JBT, Baier J, Ehlenz N, Tonga SLK, Tsakem B, Matshitse R, Tsafack BT, Eckhardt P, Ponou BK, Opatz T, Tapondjou LA, Celik I, Siwe-Noundou X, Teponno RB.   +14 more
europepmc   +1 more source

Genetic Modifiers of ABCA1 Activity Interact with APOE Isoforms to Mediate Alzheimer's Disease Risk

Annals of Neurology, EarlyView.
Objective ATP‐binding cassette transporter A1 (ABCA1) has been associated with Alzheimer's disease (AD), but the mechanisms by which it impacts disease risk are unknown. ABCA1 is known to bind apolipoprotein E (ApoE) and catalyze apolipoprotein lipidation.
Andrés Peña‐Tauber, Ricardo Hernández Arriaza, Dylan Reil, Manon Muntaner, Junyoung Park, Benjamin Grenier‐Boley, Marc Hulsman, Philippe Amouyel, Céline Bellenguez, Camille Charbonnier, Jean‐François Deleuze, Orio Dols‐Icardo, John Hardy, Henne Holstege, Gaël Nicolas, Simon Mead, Michael Wagner, Alfredo Ramirez, Rebecca Sims, John van Swieten, Julie Willams, Jean‐Charles Lambert, Chaitan Khosla, Yann Le Guen, Michael D Greicius   +24 more
wiley   +1 more source

Efflux pumps positively contribute to rifampin resistance in rpoB mutant Mycobacterium tuberculosis. [PDF]

Ann Clin Microbiol Antimicrob
Meng F, Chen Y, Wei Z, Liu Z, Lai X, Lei J, Wu L, Deng L, Wang Q, Yang Y, Li H, Xie B, Gong L, Niu Q, Gao J, Wang N, Hu J.   +16 more
europepmc   +1 more source

Identification of oxyresveratrol, a food-as-medicine substrate, as a novel EPI that targets the RND efflux pumps of <i>Serratia surfactantfaciens</i> sp. nov. YD25^T. [PDF]

Microbiol Spectr
Liu F, Wei X, Lou Y, Wang Y, Zhang D, Cao B, Su C, Sun Y, Li Z.   +8 more
europepmc   +1 more source

Inhibitory potential of pentagalloyl glucose against efflux pumps in <i>Staphylococcus aureus</i>. [PDF]

RSC Adv
Harikumar K, Singh U, Ramaraj SK, Rekha LA, Nayak A, Ghosh P, Prasad R, Philip A, Sahu S, Nelson-Sathi S.   +9 more
europepmc   +1 more source

Conformational plasticity across phylogenetic clusters of RND multidrug efflux pumps and its impact on substrate specificity. [PDF]

Nat Commun
Lazarova M, Eicher T, Börnsen C, Zeng H, Athar M, Okada U, Yamashita E, Spannaus IM, Borgosch M, Cha HJ, Vargiu AV, Murakami S, Diederichs K, Frangakis AS, Pos KM.   +14 more
europepmc   +1 more source

Association between overexpression of efflux pumps genes Rv0191 and Rv3008 and pyrazinamide resistance in multidrug-resistant Mycobacterium tuberculosis: a multi-center study. [PDF]

BMC Infect Dis
Hashemzadeh M, Hamid S, Khosravi AD, Soleimanpour S, Savari M.   +4 more
europepmc   +1 more source

Specificity and tunability of efflux pumps: A new role for the proton gradient? [PDF]

PLoS Comput Biol
Gerry M, Kirby D, Alexandrov BS, Segal D, Zilman A.   +4 more
europepmc   +1 more source

Correction: Staphylococcus aureus in commercial laying hens from Pernambuco, Brazil: detection of efflux pumps and β-lactam resistance genes. [PDF]

Braz J Microbiol
da Silva ÓP, de Sá Barreto Maia Leite DP, da Silva VV, Barbosa IC, Dos Santos SF, Barros MR, Mota RA.   +6 more
europepmc   +1 more source