Results 151 to 160 of about 1,228,475 (265)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Effort-Reward Imbalance and Subjective Well-Being of Chinese residency training mentors: the role of social emotions and over-commitment. [PDF]

Front Public Health
Yang H, Zhu A, Xue D, Zheng J, Yang J.
europepmc   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Modifying the Meaning of the Upper Anchor Predictably Shapes Ratings of Perceived Effort: A Randomized Crossover Trial. [PDF]

Sports Med Open
Okhamafe D, Silverman Y, Vigotsky AD, Halperin I.   +3 more
europepmc   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Contributions of the basolateral amygdala and nucleus accumbens to sustaining not just initiating cognitive effort. [PDF]

Proc Natl Acad Sci U S A
Dixon ML, Blevins E, Dweck CS, Görgen K, Knutson B.   +4 more
europepmc   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Apathy, effort-based decisions and brain integrity in Alzheimer's and Parkinson's diseases. [PDF]

Brain
Morris LA, Suzuki H, Lee S, Jin Z, Chen BB, Marin A, Huey ED, Gazes Y, Heilbronner SR, Le Heron CJ, Vanegas-Arroyave N.   +10 more
europepmc   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Optimal Harvesting in Stream Networks: Maximizing Biomass and Yield. [PDF]

Bull Math Biol
Nguyen TD, Shuai Z, Tang T, Veprauskas A, Wu Y, Zhou Y.   +5 more
europepmc   +1 more source