Results 171 to 180 of about 4,990,704 (352)

A team effort [PDF]

Nature, 2003
openaire   +2 more sources

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Dietary interventions interact with the perception of effort and enhance endurance performance: a brief narrative review. [PDF]

J Int Soc Sports Nutr
Strasser B, Burtscher J, Álvarez-Herms J, Kopp M, Pageaux B, Burtscher M.   +5 more
europepmc   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Effort-reward imbalance at work and incident coronary heart disease: a multicohort study of 90,164 individuals

, 2017
Background: Epidemiologic evidence for work stress as a risk factor for coronary heart disease is mostly based on a single measure of stressful work known as job strain, a combination of high demands and low job control.
Mika Kivimaki (2222011), Raimund Erbel (49439), Martin L. Nielsen (7245353), Goran Fahle (7245344), Mark Hamer (1254141), Maria Nordin (152538), Marcel Goldberg (111570), Nico Dragano (49434), Karl-Heinz Jockel (7245347), Anders Knutsson (152485), Marianna Virtanen (152568), Tuula Oksanen (329144), Lars Alfredsson (39207), Jaana Pentti (152542), Eleonor I. Fransson (7241801), Paula Salo (152546), Hugo Westerlund (136420), G. David Batty (7238753), Solja T. Nyberg (7241798), Marie Zins (111574), Jussi Vahtera (130274), Hermann Burr (152447), Ida E.H. Madsen (7245350), Reiner Rugulies (152550), Katriina Heikkila (7243337), Andrew Steptoe (36331), Lunau Thorsten (7245341), Tores Theorell (7242911), Marianne Borritz (152444), Jan H. Pejtersen (7245356), Jurgen Schupp (7245359), Peter J.M. Westerholm (7242914), Johannes Siegrist (49440), Jakob B. Bjorner (7241804), Archana Singh-Manoux (152590)   +34 more
core  

"Protected time" for clinical investigators in medical oncology: The persistent gap between expectation and reality. [PDF]

Cancer
Sedrak MS, Ramalingam SS, Sparano JA.
europepmc   +1 more source

Effort and Achievement [PDF]

Perfusion, 2009
openaire   +2 more sources

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Verbal and Visuospatial Working Memory Performance During the CO₂ Challenge Model of Anxiety. [PDF]

Hum Psychopharmacol
Dunger W, Edwards M, Board A, Garner M.
europepmc   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source