Results 91 to 100 of about 2,811,705 (290)

GVSEE: A Global Village Service Effort Estimator to Estimate Software Services Development Effort

open access: yesApplied Artificial Intelligence, 2016
As software services have become a main and basic part of companies in recent years, accurate and efficient estimates of required effort for their development has turned into a major concern. Furthermore, the great variety, complexity, nonnormality, and inconsistency of software services have made estimation of the needed development effort a very ...
Amid Khatibi Bardsiri   +2 more
openaire   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

open access: yesFEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa   +2 more
wiley   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

open access: yesFEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar   +4 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

Software Project Effort Estimation

open access: yes, 2022
Software effort estimation is one of the oldest and most important problems in software project management, and thus today there are a large number of models, each with its own unique strengths and weaknesses in general, and even more importantly, in ...
Jeffrey, Ross, Trendowicz, Adam
core   +1 more source

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

open access: yesFEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee   +2 more
wiley   +1 more source

REBEE- Reusability Based Effort Estimation Technique using Dynamic Neural Network [PDF]

open access: yes, 2011
Software Effort Estimation has been researched for over 25 years but until today no real effective model could be designed that could efficiently gauge the effort required for heterogeneous project data.
Jyoti Mahajan, Kashyap Dhruve, Devanand
core  

Hybrid intelligence effort for software effort estimation in LLM assisted development

open access: yesDiscover Computing
Software effort estimation remains a cornerstone of project planning and control, yet existing estimation models are grounded in the assumption that software development effort is dominated by human reasoning and manual construction.
Feisal Alaswad   +5 more
doaj   +1 more source

Enhancing Software Effort Estimation in the Analogy-Based Approach Through the Combination of Regression Methods

open access: yesIEEE Access
The success of software projects is closely linked to accurate effort estimation, driving continuous efforts by researchers to refine estimation methods.
Taghi Javdani Gandomani   +3 more
doaj   +1 more source

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