Results 111 to 120 of about 173,318 (310)
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
An Empirical investigation into software effort estimation by analogy
Most practitioners recognise the important part accurate estimates of development effort play in the successful management of major software projects. However, it is widely recognised that current estimation techniques are often very inaccurate, while ...
Schofield, Christopher
core
Software Effort Prediction - A Fuzzy Logic Approach
, 2013 Accuracy in the estimation of software Effort/Cost is one of the desirable criteria for any software cost estimation model. The estimation of effort or cost before the actual development of any software is the most crucial task of the present day ...
Vandana Bhattacherjee +2 more
core
The Implementation of Machine Learning for Software Effort Estimation: A Literature Review
Khazanah InformatikaEffort estimation is pivotal for the triumph of software development endeavors. The appropriate forecasting approach is vital for aligning software project effort estimation outcomes.
Eva Hariyanti +7 more
doaj +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source
, 2008 : Estimating development effort remains a complex problem attracting considerable research attention. Improving the estimation techniques available to project managers would facilitate more effective control of time and budgets in software development ...
J. D. Simões Da Silva +1 more
core
Effort Estimation Model for Software Customisation Projects
, 2014 Effort estimation is an important and challenging issue in software engineering. Software developers and/or project managers need to estimate the effort early in the software development life cycle, to evaluate the appropriate budget and manpower ...
Hasan, Md. Mahmudul
core +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Published studies on agile effort estimation predominantly focus on comparisons of the accuracy of different estimation methods, while efficiency comparisons, i.e. how much time the estimation methods consume was not in the forefront.
Fürst, Luka +3 more
core +1 more source