Results 101 to 110 of about 2,811,705 (290)

Improvement of effort estimation accuracy in software projects using a feature selection approach [PDF]

Journal of Advances in Computer Engineering and Technology, 2016
In recent years, utilization of feature selection techniques has become an essential requirement for processing and model construction in different scientific areas.
Zahra Shahpar, Vahid Khatibi, Asma Tanavar, Rahil Sarikhani   +3 more
doaj  

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Handling categorical variables in effort estimation

Proceedings of the ACM-IEEE international symposium on Empirical software engineering and measurement, 2012
Background: Accurate effort estimation is the basis of the software development project management. The linear regression model is one of the widely-used methods for the purpose. A dataset used to build a model often includes categorical variables denoting such as programming languages.
Masateru Tsunoda, Sousuke Amasaki, Akito Monden   +2 more
openaire   +3 more sources

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Evaluation of the accuracy of established patient inspiratory effort estimation methods during mechanical support ventilation. [PDF]

Heliyon, 2023
van Diepen A, Bakkes THGF, De Bie AJR, Turco S, Bouwman RA, Woerlee PH, Mischi M.   +6 more
europepmc   +1 more source

Estimation Metrics for Courseware Maintenance Effort

J. Univers. Comput. Sci., 1998
Software engineering methods and metrics to estimate development time for the development and maintenance of computer-based training (CBT) differ from methods and metrics used to develop large information systems. The estimation techniques for large information systems employ Lines-Of-Code and Feature/Function points to calculate project effort in ...
Thackaberry,Christine, Rada,Roy
openaire   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Stacking regularization in analogy-based software effort estimation. [PDF]

Soft comput, 2022
Kaushik A, Kaur P, Choudhary N, Priyanka.   +3 more
europepmc   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source