Results 121 to 130 of about 173,318 (310)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

An Investigation into Software Estimation Methods

There are currently no fully validated estimation approaches that can accurately predict the effort needed for developing a software system (Kitchenham, et al, 1995).
Hamdan, Khaled
core  

Software Project Duration Estimation Using Metrix Model [PDF]

This paper analyzes the existing types of duration estimation models for software projects and advances a new, user-friendly model for project duration estimation.
Marius VETRICI
core  

Effort Estimation: Maxwell

, 2009
<p>Dataset for Effort Estimation</p> <p> </p> <p><strong>Reference</strong></p> <p>1 K. D. Maxwell. 2002. Applied Statistics for Software Managers. Englewood Cliffs, NJ.
Yanfu Li (5206744), Yanfu Li
core   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Estimation of inspiratory muscle effort using three common indices in various respiratory models, a bench study

Background Liberation from mechanical ventilation is a complex therapeutic challenge in the intensive care unit. Estimating inspiratory effort during mechanical ventilation can mitigate lung and diaphragmatic injury, along with weakness and atrophy ...
Ehab Daoud, Osama Hasan, Yusuke Hirao, Joshua Hu, Kazushige Shiraishi   +4 more
core   +1 more source

Estimation Metrics for Courseware Maintenance Effort

, 1998
Software engineering methods and metrics to estimate development time for the development and maintenance of computer-based training (CBT) differ from methods and metrics used to develop large information systems.
Rada,Roy, Rada, Roy, Thackaberry,Christine, Thackaberry, Christine   +3 more
core   +1 more source

Systematic Literature Review on Effort Estimation by Software Development Life Cycle Phases

IEEE Access
Several techniques have been proposed to estimate the total effort of the Software Development Life Cycle (SDLC) rather than by SDLC phase to be performed for an independent team.
Sulem Martinez-Aguilar, Angel J. Sanchez-Garcia, Cuauhtemoc Lopez-Martin, Jorge Octavio Ocharan-Hernandez   +3 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source