Results 1 to 10 of about 1,833 (117)

EFTUD2 is a promising diagnostic and prognostic indicator involved in the tumor immune microenvironment and glycolysis of lung adenocarcinoma. [PDF]

Front Oncol
BackgroundElongation Factor Tu GTP Binding Domain Containing 2 (EFTUD2), a conserved spliceosomal GTPase, is involved in craniofacial development and various cancers, but its role in lung adenocarcinoma (LUAD) remains unclear.MethodsEFTUD2 expression in ...
Yin A, Xu Y, Su X, Wang R, Zhang Z, Chen Y, Han L, Fu G, Wang W, Wang J.   +9 more
europepmc   +5 more sources

Interaction of Newcastle disease virus V protein with EFTUD2 modulates MDA5 pathway to suppress viral replication. [PDF]

Poult Sci
Elongation factor Tu GTP-binding domain-containing protein 2 (EFTUD2), a core component of U5 small nuclear ribonucleoprotein particles (snRNPs), recently emerged as a novel innate immune regulator.
Han Y, Zhang F, Zhou Z, Huang Y, Chen R.
europepmc   +2 more sources

Spliceosomal GTPase Eftud2 regulates microglial activation and polarization. [PDF]

Neural Regen Res, 2023
Elongation factor Tu GTP binding domain protein 2 (Eftud2) is a spliceosomal GTPase that serves as an innate immune modulator restricting virus infection.
Yang GC, Shi Y, Fan CN, Li Y, Yuan MQ, Pei J, Wu Y, Wu HT.   +7 more
europepmc   +2 more sources

The Spliceosome Factor EFTUD2 Promotes IFN Anti-HBV Effect through mRNA Splicing. [PDF]

Mediators Inflamm, 2023
Background/Aims. The underlying mechanisms of differential responsiveness to IFN remain poorly understood. The elongation factor Tu GTP binding domain-containing protein 2 (EFTUD2), involved in RNA splicing and pre-mRNA processing, was recognized as a ...
Hu P, Li Y, Zhang W, Liu R, Peng L, Xu R, Cai J, Yuan H, Feng T, Tian A, Yue M, Li J, Li W, Zhu C.   +13 more
europepmc   +2 more sources

LncRNA CA13/EFTUD2/CA13 caused crossed beak by regulating the mandibular calcification in chicken. [PDF]

Poult Sci
Crossed beak is a beak deformity that reduces feeding and drinking in affected chickens, thereby diminishing chicken production performance. Previous studies have shown that long non-coding RNA CA13 (lncRNA CA13), as an upstream regulator of carbonic ...
Wu M, Su D, Li X, Xu J, Fan Y, Wu X, Liu X, Su B, Wang D, Chen Y, Hao E, Bai H, Chen H, Chen J, Shi L.   +14 more
europepmc   +2 more sources

Plerixafor and resatorvid inhibit hepatitis B virus in vitro by upregulating elongation factor Tu GTP-binding domain containing 2. [PDF]

Front Cell Infect Microbiol, 2023
BackgroundAn increase in the demand for a functional cure has accelerated research on new methods of therapy for chronic hepatitis B, which is mainly focused on restoring antiviral immunity for controlling viral infections.
Cai J, Li Y, Hu P, Xu R, Yuan H, Zhang W, Feng T, Liu R, Li W, Zhu C.   +9 more
europepmc   +2 more sources

U5 snRNP Core Proteins Are Key Components of the Defense Response against Viral Infection through Their Roles in Programmed Cell Death and Interferon Induction. [PDF]

Viruses, 2022
The spliceosome is a massive ribonucleoprotein structure composed of five small nuclear ribonucleoprotein (snRNP) complexes that catalyze the removal of introns from pre-mature RNA during constitutive and alternative splicing. EFTUD2, PRPF8, and SNRNP200
Boudreault S, Lemay G, Bisaillon M.
europepmc   +2 more sources

EFTUD2 Regulates Cortical Morphogenesis via Modulation of Caspase-3 and Aifm1 Splicing Pathways. [PDF]

Adv Sci (Weinh)
Elongation Factor Tu GTP‐Binding Domain Containing 2 (EFTUD2), a core spliceosomal GTPase associated with Mandibulofacial Dysostosis with Microcephaly (MFDM), plays a mechanistically undefined role in cerebral development.
Chen L, Li Y, Yu Y, Cai M, Li H, Huang M, Yang G, Guo J, Wang H, Song Z, Shen W, Jiang H, Wu H.   +12 more
europepmc   +2 more sources

Recurrent mandibulofacial dysostosis, Guion-Almeida type in consecutive pregnancies due to maternal mosaicism of a novel EFTUD2 variant: a case report and review of the literature. [PDF]

J Med Case Rep
Background Mandibulofacial dysostosis, Guion-Almeida type is an autosomal dominant disorder characterized by craniofacial malformations and intellectual disability.
Wang B, Hua C, Liu Q, Cai D.
europepmc   +2 more sources

Addressing the tissue specificity of U5 snRNP spliceosomopathies. [PDF]

Front Cell Dev Biol
Precursor mRNA (pre-mRNA) must undergo splicing to remove intron sequences and join exons. This splicing process is catalysed by an RNA/protein complex called the spliceosome.
Kemal RA, O'Keefe RT.
europepmc   +2 more sources