Results 41 to 50 of about 1,217 (167)

Multifunctional RNA-binding proteins influence mRNA abundance and translational efficiency of distinct sets of target genes.

PLoS Computational Biology, 2021
RNA-binding proteins (RBPs) can regulate more than a single aspect of RNA metabolism. We searched for such previously undiscovered multifunctionality within a set of 143 RBPs, by defining the predictive value of RBP abundance for the transcription and ...
Valentin Schneider-Lunitz, Jorge Ruiz-Orera, Norbert Hubner, Sebastiaan van Heesch   +3 more
doaj   +1 more source

A de novo synonymous variant in EFTUD2 disrupts normal splicing and causes mandibulofacial dysostosis with microcephaly: case report

BMC Medical Genetics, 2020
Background Mandibulofacial dysostosis with microcephaly (MFDM) is a rare autosomal dominant genetic disease characterized by intellectual and growth retardations, as well as major microcephaly, induced by missense and splice site variants or ...
Arthur Jacob, Jennifer Pasquier, Raphael Carapito, Frédéric Auradé, Anne Molitor, Philippe Froguel, Khalid Fakhro, Najeeb Halabi, Géraldine Viot, Seiamak Bahram, Arash Rafii   +10 more
doaj   +1 more source

EFTUD2 gene deficiency disrupts osteoblast maturation and inhibits chondrocyte differentiation via activation of the p53 signaling pathway

Human Genomics, 2019
Background Mandibulofacial dysostosis with microcephaly (MFDM) is characteristic of multiple skeletal anomalies comprising craniofacial anomalies/dysplasia, microcephaly, dysplastic ears, choanal atresia, and short stature.
Jing Wu, Yi Yang, You He, Qiang Li, Xu Wang, Chengjun Sun, Lishun Wang, Yu An, Feihong Luo   +8 more
doaj   +1 more source

A functional loop between YTH domain family protein YTHDF3 mediated m6A modification and phosphofructokinase PFKL in glycolysis of hepatocellular carcinoma

Journal of Experimental & Clinical Cancer Research, 2022
Background & aims N6-methyladenosine (m6A) modification plays a critical role in progression of hepatocellular carcinoma (HCC), and aerobic glycolysis is a hallmark of cancer including HCC.
Rong Zhou, Wen Ni, Chao Qin, Yunxia Zhou, Yuqing Li, Jianping Huo, Lijuan Bian, Aijun Zhou, Jianming Li   +8 more
doaj   +1 more source

Dermatan Sulfate Is a Potential Regulator of IgH via Interactions With Pre-BCR, GTF2I, and BiP ER Complex in Pre-B Lymphoblasts

Frontiers in Immunology, 2021
Dermatan sulfate (DS) and autoantigen (autoAg) complexes are capable of stimulating autoreactive CD5+ B1 cells. We examined the activity of DS on CD5+ pre-B lymphoblast NFS-25 cells.
Jongmin Lee, Jung-hyun Rho, Michael H. Roehrl, Julia Y. Wang   +3 more
doaj   +1 more source

Weighted Gene Co-Expression Network Analysis (WGCNA) Discovered Novel Long Non-Coding RNAs for Polycystic Ovary Syndrome

Biomedicines, 2023
Polycystic ovary syndrome (PCOS) affects reproductive-age women. This condition causes infertility, insulin resistance, obesity, and heart difficulties. The molecular basis and mechanism of PCOS might potentially generate effective treatments.
Roozbeh Heidarzadehpilehrood, Maryam Pirhoushiaran, Malina Binti Osman, Habibah Abdul Hamid, King-Hwa Ling   +4 more
doaj   +1 more source

Alternative spliceosomal protein Eftud2 mediated Kif3a exon skipping promotes SHH-subgroup medulloblastoma progression. [PDF]

Cell Death Differ
Abstract Alternative splicing plays a pivotal role in various facets of organogenesis, immune response, and tumorigenesis. Medulloblastoma represents a prevalent childhood brain tumor, with approximately one-third classified as the Sonic Hedgehog (SHH) subgroup.
Li Y, Chen L, Xue S, Song Z, Liu H, Li H, Shen W, Zhang C, Wu H.   +8 more
europepmc   +4 more sources

Time-course RNA-Seq profiling reveals isoform-level gene expression dynamics of the cGAS-STING pathway

Computational and Structural Biotechnology Journal, 2022
The cGAS-STING pathway, orchestrating complicated transcriptome-wide immune responses, is essential for host antiviral defense but can also drive immunopathology in severe COVID-19.
Jing Sun, Lu Li, Jiameng Hu, Yan Gao, Jinyi Song, Xiang Zhang, Haiyang Hu   +6 more
doaj   +1 more source

Spliceosome protein Eftud2 promotes colitis-associated tumorigenesis by modulating inflammatory response of macrophage [PDF]

Mucosal Immunology, 2019
Alternative splicing (AS) of mRNA is known to be involved in regulation of immune cell differentiation and activation. Elongation factor Tu GTP binding domain containing 2 (Eftud2) is an AS factor to potentially modulate innate immune response in macrophages. In this study, we investigate its involvement in the pathogenesis of colitis-associated cancer
Zhonglin, Lv, Zhihong, Wang, Longlong, Luo, Yu, Chen, Gencheng, Han, Renxi, Wang, He, Xiao, Xinying, Li, Chunmei, Hou, Jiannan, Feng, Beifen, Shen, Yi, Wang, Hui, Peng, Renfeng, Guo, Yan, Li, Guojiang, Chen   +15 more
openaire   +2 more sources

Gene markers of fracture healing in early stage and the regulatory mechanism during the process using microarray analysis

Acta Orthopaedica et Traumatologica Turcica, 2016
Background: The aim of this study was to explore crucial markers and uncover the regulatory mechanisms of fracture healing in the early stage. Methods: Gene expression profile of GSE45156 was downloaded, in which 3 fractured samples and 3 unfractured ...
Chengxue Wang, Baochang Qi, Lei Tan, Jieping Cheng   +3 more
doaj   +1 more source