Alternative spliceosomal protein Eftud2 mediated Kif3a exon skipping promotes SHH-subgroup medulloblastoma progression. [PDF]
Cell Death DifferAbstract Alternative splicing plays a pivotal role in various facets of organogenesis, immune response, and tumorigenesis. Medulloblastoma represents a prevalent childhood brain tumor, with approximately one-third classified as the Sonic Hedgehog (SHH) subgroup.
Li Y +8 more
europepmc +4 more sources
Frontiers in Immunology, 2021 Dermatan sulfate (DS) and autoantigen (autoAg) complexes are capable of stimulating autoreactive CD5+ B1 cells. We examined the activity of DS on CD5+ pre-B lymphoblast NFS-25 cells.
Jongmin Lee +3 more
doaj +1 more source
Spliceosome protein Eftud2 promotes colitis-associated tumorigenesis by modulating inflammatory response of macrophage [PDF]
Mucosal Immunology, 2019 Alternative splicing (AS) of mRNA is known to be involved in regulation of immune cell differentiation and activation. Elongation factor Tu GTP binding domain containing 2 (Eftud2) is an AS factor to potentially modulate innate immune response in macrophages. In this study, we investigate its involvement in the pathogenesis of colitis-associated cancer
Zhonglin, Lv +15 more
openaire +2 more sources
Genotype of embryos collected from matings of Eftud2+/- with Eftud2+/- mice on the mixed CD1;FvB genetic background. [PDF]
, 2019 Genotype of embryos collected from matings of Eftud2+/- with Eftud2+/- mice on the mixed CD1;FvB genetic background.
Anissa Djedid (6919970) +6 more
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Biomedicines, 2023 Polycystic ovary syndrome (PCOS) affects reproductive-age women. This condition causes infertility, insulin resistance, obesity, and heart difficulties. The molecular basis and mechanism of PCOS might potentially generate effective treatments.
Roozbeh Heidarzadehpilehrood +4 more
doaj +1 more source
HER2:EFTUD2 digital PCR for determinant of HER2 status. [PDF]
, 2013 Representative droplet digital plots from a tumour with high level amplification (left panel), low level amplification (middle panel) and a non-amplified tumour (right panel). The four quadrants represent top left: droplets with HER2 DNA only, top right:
Isaac Garcia-Murillas (502434) +2 more
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DataSheet_1_Plerixafor and resatorvid inhibit hepatitis B virus in vitro by upregulating elongation factor Tu GTP-binding domain containing 2.docx [PDF]
, 2023 BackgroundAn increase in the demand for a functional cure has accelerated research on new methods of therapy for chronic hepatitis B, which is mainly focused on restoring antiviral immunity for controlling viral infections.
Wenting Li (177115) +9 more
core +1 more source
Computational and Structural Biotechnology Journal, 2022 The cGAS-STING pathway, orchestrating complicated transcriptome-wide immune responses, is essential for host antiviral defense but can also drive immunopathology in severe COVID-19.
Jing Sun +6 more
doaj +1 more source
MOESM2 of EFTUD2 gene deficiency disrupts osteoblast maturation and inhibits chondrocyte differentiation via activation of the p53 signaling pathway [PDF]
, 2019 Additional file 2: Figure S1. eftud2 expression pattern in WT zebrafish. A: eftud2 expression in zebrafish embryos at 24hpf (a, b), 48hpf (c, d), 3dpf (e, f) and 5dpf (g, h) was examined using whole-mount in situ hybridization over a period of 5 days ...
Lishun Wang (6542) +8 more
core +1 more source
EFTUD2 deficiency in vertebrates: Identification of a novel human mutation and generation of a zebrafish model [PDF]
Birth Defects Research Part A: Clinical and Molecular Teratology, 2015 BackgroundCongenital microphthalmia and coloboma are severe developmental defects that are frequently associated with additional systemic anomalies and display a high level of genetic heterogeneity.MethodsTo identify the pathogenic variant in a patient with microphthalmia, coloboma, retinal dystrophy, microcephaly, and other features, whole exome ...
Brett, Deml +4 more
openaire +2 more sources