Results 71 to 80 of about 1,898 (155)

Eradication of unresectable liver metastasis through induction of tumour specific energy depletion. [PDF]

, 2019
Treatment of liver metastasis experiences slow progress owing to the severe side effects. In this study, we demonstrate a strategy capable of eliminating metastatic cancer cells in a selective manner.
Chen, Guojun, Chen, Qian, Gu, Zhen, Hu, Yong, Huo, Da, Jiang, Wei, Jiang, Xiqun, Luo, Xingyu, Zhang, Chao, Zhu, Jianfeng   +9 more
core  

Targeting Mesothelin Enhances Personalized Neoantigen Vaccine Induced Antitumor Immune Response in Orthotopic Pancreatic Cancer Mouse Models

Advanced Science, Volume 12, Issue 12, March 27, 2025.
Targeting mesothelin (MSLN) improved neoantigen vaccine efficacy in pancreatic cancer by reducing apCAFs, which disrupted the conversion of naive CD4+ T cells into Tregs and enhanced the infiltration of IFN‐γ+CD4+ and GZMK+CD8+ T cells. This combination strengthened neoantigen‐specific T cell response to overcome the immunosuppressive tumor ...
Zhixiong Cai, Zhenli Li, Wenting Zhong, Fangzhou Lin, Xiuqing Dong, Honghao Ye, Yutong Guo, Geng Chen, Xiaoling Yu, Haijun Yu, Ruijing Tang, Xiaolong Liu   +11 more
wiley   +1 more source

Long non-coding RNA SENCR is a positive regulator of ETV2 [PDF]

, 2017
Department of Biological SciencesAlthough long non-coding RNAs (lncRNAs) have emerged as novel regulator of cell fate and gene expression, the regulation of vascular specific transcription factor by lncRNA in generation of induced endothelial cells ...
Jeong, Yujin
core  

Understanding GEMIN5 Interactions: From Structural and Functional Insights to Selective Translation

WIREs RNA, Volume 16, Issue 2, March/April 2025.
GEMIN5 structural domains. Overview of GEMIN5's role in snRNP assembly and translation regulatory events. ABSTRACT GEMIN5 is a predominantly cytoplasmic protein, initially identified as a member of the survival of motor neurons (SMN) complex. In addition, this abundant protein modulates diverse aspects of RNA‐dependent processes, executing its ...
Encarnacion Martinez‐Salas, Salvador Abellan, Rosario Francisco‐Velilla   +2 more
wiley   +1 more source

Delineation of the Genetic Architecture and Clinical Polymorphism of 3q29 Duplication Syndrome: A Review of the Literature and a Report of Two Novel Patients With Single‐Gene BDH1 Duplications

Molecular Genetics &Genomic Medicine, Volume 13, Issue 1, January 2025.
ABSTRACT Background Chromosome 3q29 duplication syndrome is a rare chromosomal disorder with a frequency of 1:5000 in patients with a neurodevelopmental phenotype. The syndrome is characterized by phenotypic polymorphism and reduced penetrance. Methods Patients were investigated by performing a cytogenetic analysis of GTG‐banded metaphases, aCGH with ...
A. A. Kashevarova, M. E. Lopatkina, O. Yu. Vasilyeva, D. A. Fedotov, A. D. Lobanov, E. A. Fonova, I. Z. Zhalsanova, A. A. Zarubin, O. A. Salyukova, E. O. Belyaeva, V. V. Petrova, E. G. Ravzhaeva, A. A. Agafonova, A. D. Cheremnykh, N. B. Torkhova, S. L. Vovk, I. N. Lebedev   +16 more
wiley   +1 more source

LncRNA DGUOK-AS1 Promotes Bladder Cancer Progression by Enhancing EFTUD2 Stability

Cancer Research and Treatment
Long noncoding RNAs (lncRNAs) are increasingly being recognized to play important roles in cancer pathogenesis. However, the functional mechanisms of most lncRNAs remain poorly understood.RNA sequencing was performed to identify differentially expressed lncRNAs between non-muscle-invasive bladder cancer (NMIBC) and muscle-invasive bladder cancer (MIBC).
Wenwei, Ying, Dingliang, Li, Ninghan, Feng, Wei, Wei   +3 more
openaire   +2 more sources

Identifying biological pathways that underlie primordial short stature using network analysis [PDF]

, 2014
Mutations in CUL7, OBSL1 and CCDC8, leading to disordered ubiquitination, cause one of the commonest primordial growth disorders, 3-M syndrome. This condition is associated with i) abnormal p53 function, ii) GH and/or IGF1 resistance, which may relate to
Black, Graeme C M, Clayton, Peter E., Hanson, Daniel, Murray, Philip G., Stevens, Adam   +4 more
core   +1 more source

Inhibition of SNW1 association with spliceosomal proteins promotes apoptosis in breast cancer cells [PDF]

, 2015
名古屋大学Nagoya University博士(医学)doctoral ...
58790, 58791, Sato, Naoki, 佐藤, 直紀   +3 more
core  

Exome-wide association study of pancreatic cancer risk [PDF]

, 2018
We conducted a case-control exome-wide association study to discover germline variants in coding regions that affect risk for pancreatic cancer, combining data from 5 studies. We analyzed exome and genome sequencing data from 437 patients with pancreatic
Biankin, Andrew, Borgida, Ayelet, Cleary, Sean, Connor, Ashton A., Cook, Natalie, Denroche, Robert E., Gallinger, Steven, Grant, Robert C., Grimmond, Sean M., Klein, Alison P., Lemire, Mathieu, Moore, Malcolm, Peterson, Gloria, Roberts, Nicholas J., Smith, Alyssa L., Stein, Lincoln, Virtanen, Carl, Wilson, Julie M., Zogopolous, George   +18 more
core   +1 more source

Additional file 1 of The feedback loop of EFTUD2/c-MYC impedes chemotherapeutic efficacy by enhancing EFTUD2 transcription and stabilizing c-MYC protein in colorectal cancer

Additional file 1: Fig. S1. EFTUD2 is significantly upregulated in 5-FU chemotherapy-resistant cells of CRC, related to Fig. 1. A Analysis of the differential expression genes (DEGs) expression in 5-FU resistant CRC cell lines compared with parental cell lines using three GEO datasets (GSE166900, GSE81005, GSE81008).
Zhu, Xiaojian, Li, Changxue, Gao, Yunfei, Zhang, Qingyuan, Wang, Tao, Zhou, Huaixiang, Bu, Fanqin, Chen, Jia, Mao, Xinjun, He, Yulong, Wu, Kaiming, Li, Ningning, Luo, Hongliang   +12 more
openaire   +1 more source