Results 81 to 90 of about 1,217 (167)

RNA Modifications in Health and Disease

MedComm, Volume 6, Issue 9, September 2025.
Changes in these components profoundly affect the m6A methylation process, leading to a range of physiological and pathological alterations. In recent years, research on the post‐translational modifications of these components has advanced, encompassing ubiquitination, phosphorylation, SUMOylation, O‐GlcNAcylation, and lactylation.
Shiqi Li, Ping Luo, Junli Fan, Yirong Li, Jiancheng Tu, Xinghua Long   +5 more
wiley   +1 more source

LncRNA DGUOK-AS1 Promotes Bladder Cancer Progression by Enhancing EFTUD2 Stability

Cancer Research and Treatment
Long noncoding RNAs (lncRNAs) are increasingly being recognized to play important roles in cancer pathogenesis. However, the functional mechanisms of most lncRNAs remain poorly understood.RNA sequencing was performed to identify differentially expressed lncRNAs between non-muscle-invasive bladder cancer (NMIBC) and muscle-invasive bladder cancer (MIBC).
Wenwei, Ying, Dingliang, Li, Ninghan, Feng, Wei, Wei   +3 more
openaire   +2 more sources

MOESM4 of EFTUD2 gene deficiency disrupts osteoblast maturation and inhibits chondrocyte differentiation via activation of the p53 signaling pathway

, 2019
Additional file 4: Figure S3. Zebrafish with eftud2 gene knockdown showed aberrant cartilage development. A, B: Larvae treated with an eftud2 morpholino (EMO) at 3dpf exhibited disrupted formation of Meckel’s cartilage (a) and the ceratohyals (b) upon ...
Lishun Wang (6542), You He (273437), Yu An (133201), Qiang Li (8118), Chengjun Sun (1901482), Jing Wu (54032), Feihong Luo (612837), Xu Wang (28596), Yi Yang (116183)   +8 more
core   +1 more source

Identification of NIBAN2‐Regulated RUNX2 Alternative Splicing Presents Novel Strategies for Antagonizing Osteoporosis

Advanced Science, Volume 12, Issue 17, May 8, 2025.
NIBAN2 interacts with the HNRNPU‐cored spliceosome complex and alters its components to regulate the alternative splicing of RUNX2, which ultimately cause an increase in functional RUNX2 (nuclear localization sequence complete) but a decrease in dysfunctional Runx2 (exon 6‐exclusive) isoforms to reinforce osteoblast differentiation.
Sheng Zhang, Zhiqiang Yang, Yuanlong Xie, Yufeng Zhang, Zhe Chen, Xuan Lv, Zhouming Deng, Zan Huang, Lin Cai, Renxiong Wei   +9 more
wiley   +1 more source

HER2:EFTUD2 digital PCR has high accuracy compared to conventionally defined HER2 status.

, 2013
HER2:EFTUD2 ratio was assessed by digital PCR on DNA from 18 HER2 amplified and 58 HER2 non-amplified cancers demonstrating the narrow range of HER2:EFTUD2 ratios in non-amplified cancers.
Isaac Garcia-Murillas (502434), Maryou Lambros (502435), Nicholas C. Turner (265334)   +2 more
core   +1 more source

Proteomics Analysis of the TDP‐43 Interactome in Cellular Models of ALS Pathogenesis

Journal of Neurochemistry, Volume 169, Issue 5, May 2025.
Cytoplasmic aggregation and nuclear depletion of TAR DNA‐binding protein 43 (TDP‐43) is a hallmark pathology of several neurodegenerative diseases including amyotrophic lateral sclerosis (ALS), frontotemporal lobar degeneration (FTLD) and limbic‐predominant age‐related TDP‐43 encephalopathy (LATE).
Flora Cheng, Tyler Chapman, Juliana Venturato, Jennilee M. Davidson, Stella A. Polido, Livia Rosa‐Fernandes, Rebecca San Gil, Hannah J. Suddull, Selina Zhang, Chiara Y. Macaslam, Paulina Szwaja, Roger Chung, Adam K. Walker, Stephanie L. Rayner, Marco Morsch, Albert Lee   +15 more
wiley   +1 more source

Genotype of mice weaned after breeding of Eftud2^+/- and wild-type mice.

, 2019
Genotype of mice weaned after breeding of Eftud2+/- and wild-type mice.
Anissa Djedid (6919970), Shruti Kumar (6919979), Kayla Clokie (6919976), Marie-Claude Beauchamp (3476816), Jacek Majewski (65417), Loydie Anne Jerome-Majewska (6919982), Kevin Daupin (6919973)   +6 more
core   +1 more source

Differential affinity of multifunctional RBPs for 5’ UTR structures often drives opposite quantitative TE effects.

, 2021
(A) Box and violin plots with 5’ UTR lengths for positively and negatively correlated TE targets corresponding to DDX3X, EFTUD2, and PRPF8. (B) Box and violin plots with length normalized MFE scores for positively and negatively correlated TE targets. We
Jorge Ruiz-Orera (2543938), Norbert Hubner (20203), Sebastiaan van Heesch (659460), Valentin Schneider-Lunitz (11039909)   +3 more
core   +1 more source

A Novel tRF, HCETSR, Derived From tRNA‐Glu/TTC, Inhibits HCC Malignancy by Regulating the SPBTN1‐catenin Complex Axis

Advanced Science, Volume 12, Issue 13, April 3, 2025.
HCETSR, derived from tRNA‐Glu/TTC, binds to SPTBN1, promoting the dissociation of SPTBN1 from the catenin complex and facilitating the translocation of the catenin complex from the cell membrane to the nucleus. Meanwhile, HCETSR reduces proteasomal degradation of β‐catenin and synthesis of nascent β‐catenin.
Tao Rui, Kangbei Zhu, Zonglei Mao, Jiaping Wu, Yi Pan, Qianwei Ye, Cong Chen, Aizhai Xiang, Jufeng Guo, Ning Tang, Jing Zhang, Shusen Zheng, Jian Liu, Xiao Xu   +13 more
wiley   +1 more source

Targeting Mesothelin Enhances Personalized Neoantigen Vaccine Induced Antitumor Immune Response in Orthotopic Pancreatic Cancer Mouse Models

Advanced Science, Volume 12, Issue 12, March 27, 2025.
Targeting mesothelin (MSLN) improved neoantigen vaccine efficacy in pancreatic cancer by reducing apCAFs, which disrupted the conversion of naive CD4+ T cells into Tregs and enhanced the infiltration of IFN‐γ+CD4+ and GZMK+CD8+ T cells. This combination strengthened neoantigen‐specific T cell response to overcome the immunosuppressive tumor ...
Zhixiong Cai, Zhenli Li, Wenting Zhong, Fangzhou Lin, Xiuqing Dong, Honghao Ye, Yutong Guo, Geng Chen, Xiaoling Yu, Haijun Yu, Ruijing Tang, Xiaolong Liu   +11 more
wiley   +1 more source