Results 41 to 50 of about 1,902 (167)

Profiling DNA damage response following mitotic perturbations [PDF]

, 2016
Genome integrity relies on precise coordination between DNA replication and chromosome segregation. Whereas replication stress attracted much attention, the consequences of mitotic perturbations for genome integrity are less understood.
Ellenberg, Jan, Gerlich, Daniel W., Guðjónsson, Þorkell, Hériché, Jean-Karim, Karemore, Gopal, Lukas, Claudia, Lukas, Jiri, Neumann, Beate, Pedersen, Ronni S., Pepperkok, Rainer, Rask, Maj-Britt   +10 more
core   +1 more source

Loss of function mutation of Eftud2, the gene responsible for mandibulofacial dysostosis with microcephaly (MFDM), leads to pre-implantation arrest in mouse.

PLoS ONE, 2019
Mutations in EFTUD2 are responsible for the autosomal dominant syndrome named MFDM (mandibulofacial dysostosis with microcephaly). However, it is not clear how reduced levels of EFTUD2 cause abnormalities associated with this syndrome.
Marie-Claude Beauchamp, Anissa Djedid, Kevin Daupin, Kayla Clokie, Shruti Kumar, Jacek Majewski, Loydie Anne Jerome-Majewska   +6 more
doaj   +1 more source

Multifunctional RNA-binding proteins influence mRNA abundance and translational efficiency of distinct sets of target genes.

PLoS Computational Biology, 2021
RNA-binding proteins (RBPs) can regulate more than a single aspect of RNA metabolism. We searched for such previously undiscovered multifunctionality within a set of 143 RBPs, by defining the predictive value of RBP abundance for the transcription and ...
Valentin Schneider-Lunitz, Jorge Ruiz-Orera, Norbert Hubner, Sebastiaan van Heesch   +3 more
doaj   +1 more source

The spliceosome, a potential Achilles heel of MYC-driven tumors [PDF]

, 2015
Alterations in RNA splicing are frequent in human tumors. Two recent studies of lymphoma and breast cancer have identified components of the spliceosome - the core splicing machinery - that are essential for malignant transformation driven by the ...
Anczukow, O., Krainer, A. R.
core   +1 more source

The intrinsically disordered TSSC4 protein acts as a helicase inhibitor, placeholder and multi-interaction coordinator during snRNP assembly and recycling [PDF]

, 2022
Biogenesis of spliceosomal small nuclear ribonucleoproteins (snRNPs) and their recycling after splicing require numerous assembly/recycling factors whose modes of action are often poorly understood.
Aktas, T., Bergfort, A., Freund, C., Hilal, T., Ilik, I., Kuropka, B., Wahl, M., Weber, G.   +7 more
core   +6 more sources

The feedback loop of EFTUD2/c-MYC impedes chemotherapeutic efficacy by enhancing EFTUD2 transcription and stabilizing c-MYC protein in colorectal cancer

, 2023
Abstract Background Chemoresistance remains the primary cause of mortality in colorectal cancer (CRC). However, our understanding of the molecular basis underlying CRC chemoresistance is still limited. Elongation factor Tu GTP binding domain containing 2 (EFTUD2) has been implicated as a potential oncogenic factor in various cancer types, yet ...
Xiaojian Zhu, Changxue Li, Yufei Gao, Huaixiang Zhou, Tao Wang, Fanqin Bu, Jia Chen, Yulong He, Kaiming Wu, Ningning Li, Hongliang Luo   +10 more
openaire   +1 more source

EFTUD2 maintains the survival of tumor cells and promotes hepatocellular carcinoma progression via the activation of STAT3 [PDF]

Cell Death & Disease, 2020
AbstractElongation factor Tu GTP binding domain containing 2 (EFTUD2), a spliceosomal GTPase, plays a pivotal role in multiple organ development and innate immune. It has been reported that EFTUD2 is a new host factor with activity against HCV infection.
Tu, Mengxian, He, Lu, You, Yang, Li, Jinying, Yao, Nan, Qu, Chen, Huang, Wei, Xu, Leibo, Luo, Rongcheng, Hong, Jian   +9 more
openaire   +2 more sources

Proteomics Analysis of the TDP-43 Interactome in Cellular Models of ALS Pathogenesis. [PDF]

J Neurochem
Cytoplasmic aggregation and nuclear depletion of TAR DNA‐binding protein 43 (TDP‐43) is a hallmark pathology of several neurodegenerative diseases including amyotrophic lateral sclerosis (ALS), frontotemporal lobar degeneration (FTLD) and limbic‐predominant age‐related TDP‐43 encephalopathy (LATE).
Cheng F, Chapman T, Venturato J, Davidson JM, Polido SA, Rosa-Fernandes L, San Gil R, Suddull HJ, Zhang S, Macaslam CY, Szwaja P, Chung R, Walker AK, Rayner SL, Morsch M, Lee A.   +15 more
europepmc   +2 more sources

Jerantinine A induces tumor-specific cell death through modulation of splicing factor 3b subunit 1 (SF3B1) [PDF]

, 2017
Precursor mRNA (pre-mRNA) splicing is catalyzed by a large ribonucleoprotein complex known as the spliceosome. Numerous studies have indicated that aberrant splicing patterns or mutations in spliceosome components, including the splicing factor 3b ...
Bradshaw, Tracey D., Chung, Felicia Fei-Lei, Hii, Ling-Wei, Kam, Toh-Seok, Leong, Chee-Onn, Lim, Kuan-Hon, Mai, Chun Wai, Raja, Vijay Joseph, See, Sze-Jia, Tan, Boon-Shing, Tan, Perry Faith Tze Ming, Tan, Si Hoey, Tan, Yuen-Fen, Wong, Li-Zhe, Yam, Wai Keat   +14 more
core   +1 more source

Mutational screening of splicing factor genes in cases with autosomal dominant retinitis pigmentosa [PDF]

, 2014
Purpose Mutations in genes encoding proteins from the tri-snRNP complex of the spliceosome account for more than 12% of cases of autosomal dominant retinitis pigmentosa (adRP).
Ascari, Giulia, Avila-Fernandez, Almudena, Ayuso, Carmen, Benaglio, Paola, Berson, Eliot L., Hamel, Christian, Harper, Shyana, Manes, Gaël, Rivolta, Carlo, San Jose, Patricia Fernandez   +9 more
core   +7 more sources