Results 51 to 60 of about 31,205 (214)

Restores Aβ Clearance by Overcoming PCSK9–LRP1 Dysregulation and TRIB3‐Mediated Autophagy Blockade in Alzheimer's Disease

Advanced Science, EarlyView.
PCSK9 upregulation in cerebrovascular endothelial cells and microglia destabilizes the Aβ transporter LRP1, while TRIB3‐associated autophagy blockade further limits intracellular Aβ degradation. A RAP‐modified tea‐polyphenol nanoparticle co‐delivers siPCSK9 and siTRIB3 to restore LRP1‐mediated Aβ efflux and autophagy‐dependent degradation, reducing Aβ ...
Jie Miao, Jing Wang, Yankun Li, Haipei Zhang, Yanli Zhang, Qingnian Li, Bo Xiao, Wenhu Zhou, Junhong Guo   +8 more
wiley   +1 more source

Antibacterial Activity of Green Tea and Peppermint Extracts Against Enterococcus faecalis and the Potential of EGCG in Oral Health

European Pharmaceutical Journal
Enterococcus faecalis is a significant pathogen in endodontic infections, often leading to treatment failure in root canal therapy and contributing to chronic infections.
Kováč J., Slobodníková L., Nebus B., Kurin E., Bittner Fialová S.   +4 more
doaj   +1 more source

مقایسه‌ی اثر سه ماده کراس لینک کلاژن بر استحکام باند ریزکششی کامپوزیت به عاج دندان [PDF]

مجله دانشکده دندانپزشکی اصفهان
مقدمه: ددستیابی به یک باند محکم و با ثبات بین کامپوزیت رزین و عاج در دندانپزشکی ترمیمی هنوز به عنوان یک موضوع مورد بحث باقی مانده است. هدف از این مطالعه، ارزیابی اثر گلوترآلدئید، هسپریدن و EGCG به عنوان عوامل کراس لینک کلاژنی جهت ثبات بیشتر فیبرهای کلاژن
سارا حاجتی, سارا قلی زاده, کامیار وثیق, سیده ماندانا جعفری   +3 more
doaj   +1 more source

Versatile Microgel Platform for Intervertebral Disc Degeneration Therapy: Targeting Pericyte‐Mediated Fibrosis and Protecting Nucleus Pulposus Cells

Advanced Science, EarlyView.
The engineered MMS@TRP microgel enables targeted, acid‐responsive delivery of a miR‐21 inhibitor to pericytes. It effectively suppresses disc fibrosis by inhibiting TGF‐β signaling while protecting nucleus pulposus cells via sustained, antioxidant tannic acid release.
Fei Ma, Zhen Zhao, Chuan Guo, Yuheng Liu, Yu Wang, Dengbo Yao, Weiqiang Lan, Dejun Zhong, Chen Fan, Yao He, Mei Zhang, Qingquan Kong, Yunfeng Lin   +12 more
wiley   +1 more source

Restoration of CFTR function in patients with cystic fibrosis carrying the F508del-CFTR mutation [PDF]

, 2014
Restoration of BECN1/Beclin 1-dependent autophagy and depletion of SQSTM1/p62 by genetic manipulation or autophagy-stimulatory proteostasis regulators, such as cystamine, have positive effects on mouse models of human cystic fibrosis (CF). These measures
Salvadori L, De Gregorio, Fabiola, A. Zolin, Guido, Stefano, Villella, Valeria R., Angela Sepe (663715), Zolin, Anna, Carlo A. Leone, Pinna LA, Daniela De Stefano (131144), S. Esposito, Rosa GD, Andrea Venerando (460236), D. D. Stefano, Valeria R. Villella, Speranza Esposito (663714), Villella VR, Laura Salvadori (663717), Speranza Esposito, Antonella Tosco (214447), Anna Bossi (663721), A. Tosco, Sepe A, PETTOELLO MANTOVANI, MASSIMO, Stefano Guido, Valeria Raia (524374), F. . D. Gregorio, Esposito, Speranza, Zolin A, Pinna, Lorenzo A, Villella, Valeria R, Maiuri L, Maiuri MC, G. G. Kroemer, Venerando A, Carlo A Leone (663719), A. Bossi, M. Pettoello Mantovani, Maiuri, Maria C, Kroemer, Guido, Pettoello-Mantovani, Massimo, Anna Bossi, Gianni Bona (505628), A. Venerando, Sepe, Angela, M. C. Maiuri, Leone CA, Guido Kroemer (82802), Rosa Grassia, G. D. Rosa, Antonella Tosco, Pinna, Lorenzo A., Valeria R Villella (663713), Anna Zolin, Fabiola De Gregorio, L. A. Pinna, Mehta A, Gregorio FD, Raia V., C. A. Leone, Raia, Valeria, Venerando, Andrea, Fabiola De Gregorio (663716), Grassia R, G. Bona, PINNA, LORENZO, Anna Zolin (375161), L. Salvadori, Bossi, Anna, V. R. Villella, Maiuri, Luigi, Kroemer G, Gianni Bona, Salvadori, Laura, Massimo Pettoello-Mantovani (583212), Anil Mehta, Tosco A, Laura Salvadori, Anil Mehta (202506), A. Sepe, Tosco, Antonella, Maiuri, Maria C., Stefano DD, Mehta, Anil, Rosa Grassia (663718), R. Grassia, Esposito S, Luigi Maiuri, Bossi A, Stefano Guido (112114), De Stefano, Daniela, Massimo Pettoello Mantovani, A. Mehta, Giuseppe De Rosa (206289), S. Guido, De Rosa, Giuseppe, Grassia, Rosa, Guido S, Luigi Maiuri (663723), Lorenzo A Pinna (663722), Giuseppe De Rosa, Bona G, Maria C. Maiuri, Daniela De Stefano, L. Maiuri, V. Raia, Leone, Carlo A, Bona, Gianni, Valeria Raia, Angela Sepe, Maria C Maiuri (663720), Guido Kroemer, Leone, Carlo A.   +112 more
core   +1 more source

Heat Stress in Quail: Impacts on Health and Productivity, and Mitigation Strategies

Animal Research and One Health, EarlyView.
Heat stress disrupts physiological homeostasis in quail, inducing oxidative stress, immune dysregulation, and metabolic imbalance, which impair growth, reproduction, product quality, and welfare. Integrating nutritional, environmental, and genetic–epigenetic strategies enhances thermotolerance, sustains productivity, and supports climate‐smart quail ...
T. A. Eletu, I. A. Anjola, L. O. Fasasi, D. P. Fadipe, A. T. Afuye, F. O. Fasanya, O. E. Oke   +6 more
wiley   +1 more source

Molecular interactions between (-)-epigallocatechin gallate analogs and pancreatic lipase. [PDF]

PLoS ONE, 2014
The molecular interactions between pancreatic lipase (PL) and four tea polyphenols (EGCG analogs), like (-)-epigallocatechin gallate (EGCG), (-)-gallocatechin gallate (GCG), (-)-epicatechin gallate (ECG), and (-)-epigallocatechin (EC), were studied from ...
Shihui Wang, Zeya Sun, Shengzhao Dong, Yang Liu, Yun Liu   +4 more
doaj   +1 more source

O-145 Green Tea catechins EGCG and pro-drug of EGCG (Pro-EGCG) inhibit endometriosis through targeting molecules regulating macrophages and B cells

, 2021
Study question What are the therapeutic targets and mechanisms of green tea EGCG and Pro-EGCG in treating endometriosis? Summary answer EGCG and Pro-EGCG have unique molecular targets to regulate interactions of B cells, macrophages and endometriotic ...
Wang, CC, Zhang, RZ, Zubarev, RA, Hung, SW, Gaetani, M, Tan, ZYR   +5 more
core   +1 more source

Nutrition and Metabolic Diseases: A Systematic Review of Functional Foods, Medicinal Plants, Phytochemicals, Bioactive Compounds and Nutrients Effective Against Metabolic Diseases

Food Chemistry International, EarlyView.
The study demonstrates how functional foods, medicinal plants, phytochemicals, bioactive compounds and essential nutrients combat metabolic diseases. It highlights their mechanisms, including antioxidant, anti‐inflammatory, insulin‐sensitising, lipid‐regulating, gut microbiota‐modulating and mitochondrial‐enhancing effects, leading to improved ...
Chinaza Godswill Awuchi, Sana Noreen, Sonia Morya   +2 more
wiley   +1 more source

Epigallocatechin gallate (EGCG) affects glucose metabolism and enhances fitness and life span in Drosophila melanogaster [PDF]

, 2015
In this study, we tested whether a standardized epigallocatechin-3-gallate (EGCG) rich green tea extract (comprising > 90% EGCG) affects fitness and lifespan as well as parameters of glucose metabolism and energy homeostasis in the fruit fly, Drosophila ...
Piegholdt, Stefanie, Wagner, Anika, Rabe, Doerte, Baenas, Nieves, Stocker, Achim, Schloesser, Anke, Rimbach, Gerald, Eggersdorfer, Manfred   +7 more
core   +2 more sources