Results 11 to 20 of about 132,691 (210)

Computational modelling of cancerous mutations in the EGFR/ERK signalling pathway [PDF]

, 2009
This article has been made available through the Brunel Open Access Publishing Fund - Copyright @ 2009 Orton et al.BACKGROUND: The Epidermal Growth Factor Receptor (EGFR) activated Extracellular-signal Regulated Kinase (ERK) pathway is a critical cell ...
Gormand, A, Adriaens, M.E., Adriaens, Michiel E., Kolch, W, Amelie Gormand, Adriaens, ME, Gormand, A., Sturm, OE, David R Gilbert, Richard J Orton, Walter Kolch, Orton, RJ, Orton, Richard J., Oliver E Sturm, Gilbert, D, Gilbert, David R., Michiel Adriaens, M.E., Michiel E Adriaens, Orton, R.J., Kolch, Walter, Kolch, W., Gilbert, D.R., Sturm, O.E., Sturm, Oliver E., et al., Gormand, Amelie, Gormand, Amelie,, Lund University.   +27 more
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Improved Biological Impacts of Anti-EGFR Monoclonal Antibody in KRAS-Mutant Colorectal Cancer Cells by Silica-Coated Magnetic Nanoparticle Conjugation [PDF]

Pharmaceutical Sciences
Background: The therapeutic potential of epidermal growth factor receptor (EGFR) targeting in colorectal cancer (CRC) is hindered by the presence of KRAS codon 12 activating mutations, prevalent in approximately 25% of advanced CRC cases.
Maedeh Yousefi, Hamed Farzi-Khajeh, Mostafa Akbarzadeh-Khiavi, Azam Safary, Khosro Adibkia   +4 more
doaj   +1 more source

Osimertinib – effective treatment of NSCLC with activating EGFR mutations after progression on EGFR tyrosine kinase inhibitors [PDF]

, 2017
Non-small cell lung cancer (NSCLC) driven by activating mutations in epidermal growth factor receptor (EGFR) constitutes up to 10% of NSCLC cases. According to the NCCN recommendations, all patients (with the exception of smoking patients with squamous ...
Marcin Skrzypski, Amelia Szymanowska-Narloch, Rafał Dziadziuszko   +2 more
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Blockade of Radiation-induced EGFR Nuclear Transport Enhances Radiosensitivity of Human Cervical Cancer

Zhongliu Fangzhi Yanjiu, 2020
Objective To investigate whether the inhibition of EGFR nuclear transport could reduce the radioresistance of human cervical cancer cells. Methods Human cervical cancer CaSki and HeLa cells were exposed to radiation treated with or without Thr654 ...
LI Lu, HUANG Jianming, FENG Mei, QI Yunxiang, MA Shiqi, TAN Mingyu, LANG Jinyi   +6 more
doaj   +1 more source

Canine parvovirus induces G1/S cell cycle arrest that involves EGFR Tyr1086 phosphorylation

Virulence, 2020
Canine parvovirus (CPV) has been used in cancer control as a drug delivery vehicle or anti-tumor reagent due to its multiple natural advantages. However, potential host cell cycle arrest induced by virus infection may impose a big challenge to CPV ...
Xiaofeng Dai, Xuanhao Zhang, Yujie Miao, Peiyu Han, Jianying Zhang   +4 more
doaj   +1 more source

EGFR-Targeted Liposomes Combined with Ginsenoside Rh2 Inhibit Triple-Negative Breast Cancer Growth and Metastasis

, 2023
Triple-negative breast cancer (TNBC) remains the most challenging breast cancer subtype due to its lack of targeted therapies and poor prognosis. In order to treat patients with these tumors, efforts have been made to explore feasible targets.
Aiguo Wu (315321), Canxin Xu (3847465), Aiguo Wu, Yuanbo Pan, Rui Shi, Chen Xu (53797), Wenhao Lv (10914291), Xueyin Hu, Xueyin Hu (14034184), Wenhao Lv, Chen Xu, Canxin Xu, Juan Li, Haiyan Gu, Xiahong He, Rui Shi (45165), Xiahong He (369038), Juan Li (146180), Haiyan Gu (9726796), Yuanbo Pan (14034181)   +19 more
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Epidermal growth factor receptor-mutated non-small-cell lung cancer: A primer on contemporary management

Cancer Research, Statistics, and Treatment, 2019
Non-small-cell lung cancer (NSCLC) constitutes 85% of patients diagnosed with lung cancer. In metastatic cases, its treatment classically consists of systemic cytotoxic chemotherapy, which resulted in a median overall survival of 7.9 months.
Akhil Rajendra, Vanita Noronha, Amit Joshi, Vijay Maruti Patil, Nandini Menon, Kumar Prabhash   +5 more
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Incomplete reversibility of eGFR following tenofovir exposure [PDF]

, 2014
Background. Tenofovir disoproxil fumarate (TDF) has been linked to renal impairment but the extent to which this impairment is reversible is unclear. We aimed to investigate the reversibility of renal decline on TDF.Methods.
Lisa Hamzah, Richard Gilson, Lucy J. Campbell, John Walsh, Jones, R, Chadwick, D, Frank A. Post, Post, FA, Leen, Clifford, Sophie Jose, Hill, Teresa, Campbell, Lucy J, Jose, Sophie, Campbell, Lucy J., Nitsch, D, Sabin, Caroline, Sabin, Caroline A, Dorothea Nitsch, Rachael Jones, UK Collaborative HIV Cohort Study Steering Committee, Campbell, LJ, Hay, Phillip, Johnson, M, Martin Fisher, Sabin, Caroline A., Gilson, Richard, Fisher, M, ?, ?, Johnson, Margaret, Post, Frank A, Gilson, R, Hay, P, Post, Frank A., Caroline A. Sabin, Phillip Hay, Nelson, Mark, Teresa Hill, Hamzah, L, Mark Nelson, Fisher, Martin, Walsh, J, Hill, T, Chadwick, David, Hamzah, Lisa, Margaret Johnson, David Chadwick, Sabin, CA, Walsh, John, Nelson, M, Jones, Rachael, Clifford Leen, Campbell, Lucy, Post, Frank, Jose, S, Nitsch, Dorothea, Leen, C   +55 more
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Study of EGFR expression in tumor tissue in patients with locally advanced oral cavity cancer receiving cetuximab therapy

Медицинский совет, 2020
Introduction: Squamous cell carcinoma of the oral cavity is one of the most common head and neck cancers with an aggressive course and high mortality rates.
A. A. Lyanova, L. Yu. Vladimirova, E. P. Ulianova, A. E. Storozhakova, N. A. Abramova, I. L. Popova, M. A. Teplyakova, N. M. Tikhanovskaya, V. S. Myagkova, K. A. Novoselova, L. A. Ryadinskaya, L. K. Strakhova, E. A. Kalabanova   +12 more
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EGFR-Targeted Nanobody Functionalized Polymeric Micelles Loaded with mTHPC for Selective Photodynamic Therapy

, 2020
meta-Tetra­(hydroxyphenyl)­chlorin (mTHPC) is one of the most potent second-generation photosensitizers, clinically used for photodynamic therapy (PDT) of head and neck squamous cell carcinomas.
Javier Sastre Toraño (1685377), Cornelus F. van Nostrum, Wim E. Hennink (290165), Marcel H. A. M. Fens, Irati Beltrán Hernández (8575506), Irati Beltrán Hernández, Julia Denise Peterson, Sabrina Oliveira (21108), Julia Denise Peterson (8575503), Marcel H. A. M. Fens (7105697), Bárbara Mesquita, Yanna Liu, Luca Scrivano (8575500), Sabrina Oliveira, Yanna Liu (16008), Cornelus F. van Nostrum (8298339), Luca Scrivano, Javier Sastre Toraño, Wim E. Hennink, Bárbara Mesquita (8575509)   +19 more
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