Results 21 to 30 of about 132,691 (210)

Development of a novel EGFR-targeted peptide for targeted delivery of drugs in anaplastic thyroid cancer [PDF]

, 2023
peer reviewedAnaplastic thyroid carcinoma (ATC) represents the most aggressive and deadliest thyroid cancer in human with a high proliferative and metastatic potential. The median survival of patients with ATC is of about 4 months after diagnosis and the
Journe, Fabrice, Saussez, Sven, Burtea, Carmen, Laurent, Sophie, Samuel Vandecasteele,, Marine Bougard,, Kahvecioglu, Zehra Cagla, Charlotte Rogien,   +7 more
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Interaction of GHK Tripeptide with Receptors Targeted in Some Cancer Studies: A Theoretical Approach with Molecular Docking

Hittite Journal of Science and Engineering, 2023
Cancer, defined as the uncontrolled growth and proliferation of cells, is a serious disease seen in many people around the world. For this reason, a lot of work has been done and continues to be done by scientists for the diagnosis and treatment of ...
Serda Kecel Gunduz, Bilge Bıçak
doaj   +1 more source

Hydroxygenkwanin Suppresses Non-Small Cell Lung Cancer Progression by Enhancing EGFR Degradation

Molecules, 2020
Epidermal growth factor receptor (EGFR) is frequently overexpressed and mutated in non-small cell lung cancer (NSCLC), which is the major type of lung cancer.
Yann-Lii Leu, Tong-Hong Wang, Chih-Ching Wu, Kuo-Yen Huang, Yu-Wen Jiang, Yi-Chiung Hsu, Chi-Yuan Chen   +6 more
doaj   +1 more source

Access to Diagnostics and Treatment for People With Metastatic EGFR-Positive NSCLC: Lessons From Project PRIORITY

JTO Clinical and Research Reports
Introduction: The treatment landscape for people diagnosed with EGFR-mutated (EGFR-m) NSCLC has rapidly evolved, yet there remains limited self-reported information about the lived experience.
Jill Feldman, MA, Ivy Elkins, MBA, Zofia Piotrowska, MD, Bellinda L. King-Kallimanis, PhD, Tendai Chihuri, MD, Carly Johnson, BS, Alecia Clary, PhD, Teri Kennedy, MA, Upal Basu Roy, PhD, MPH   +8 more
doaj   +1 more source

Expressions of TP53, PDGF and EGFR in Primary Astrocytomas and Their Correlation with Clinicopathological Features and Prognosis

Zhongliu Fangzhi Yanjiu, 2021
Objective To investigate the expression of TP53, PDGF and EGFR in primary astrocytomas, and analyze their correlation with clinicopathological features and prognosis.
SUN Xiaoling, ZHANG Xiaojuan, ZHANG Qingquan, QIU Lei, WANG Linna, HOU Suping   +5 more
doaj   +1 more source

THE IMPORTANCE OF DETERMINING THE UROMODULIN SERUM CONCENTRATION IN DIABETES MELLITUS TYPE 2 PATIENTS

Sanamed, 2021
Introduction: In the kidney, cells in the thick ascending limb of the loop of the Henle synthesized uromodulin (UMOD). This study aims to present the evaluation of the uromodulin serum concentration in diabetes mellitus type 2 (T2DM) patients in the ...
Jordanova Elena, Samardzic Vladimir, Pekovic-Perunicic Gordana, Tica-Jevtic Jelena, Simic-Ogrizovic Sanja   +4 more
doaj   +1 more source

Antitumor Efficacy and Mechanisms of Lapatinib in Combination with Cisplatin on Esophageal Squamous Cancer Cells

Zhongliu Fangzhi Yanjiu, 2019
Objective To evaluate the antitumor efficacy of lapatinib in combination with cisplatin on esophageal squamous cell carcinoma (ESCC) and related mechanisms.
DOU Qiaohua, GUO Xiaofang, ZHU Xiaofei, ZHANG Yueyue, YANG Fan   +4 more
doaj   +1 more source

Antitumor activity of a novel TLR9 agonist and cooperativity with targeted agents [PDF]

, 2008
Novel modified Toll-like receptor 9 (TLR9) agonists, termed immune modulatory oligonucleotides (IMOs), exhibit antitumor activity and are currently investigated in cancer patients. Intriguingly, their mechanisms of action on tumor growth and angiogenesis
Garofalo, Sonia
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EGFR-MET interaction is modulated by EGFR mutations.

, 2017
(A) Western blot (WB) of total MET levels in H1975 derived cells. Tubulin levels are shown as loading control. Values beneath blots are relative levels of MET compared to the total levels in the H1975L858R/T790M cell line from 2 independent experiments +/
Elena Ortiz-Zapater (3708226), Michael J. Neat (3708214), William Owen (3708211), Frank McCaughan (3708217), Richard W. Lee (3708220), Gilbert Fruhwirth (1886137), Peter Parker (668602), Robert G. Dunn (3708223), George Santis (210710), Gregory Weitsman (172342), Tony Ng (172369)   +10 more
core   +1 more source

Novel therapeutic approaches for EGFR-mediated drug delivery using engineered peptides in anaplastic thyroid cancer [PDF]

, 2023
peer reviewedAnaplastic thyroid carcinoma (ATC) represents the most aggressive and deadliest thyroid cancer in humans, presenting a high proliferative and metastatic potential.
Vandecasteele, Samuel, Bougard, Marine, Journe, Fabrice, Saussez, Sven, Burtea, Carmen, Rogien, Charlotte, Laurent, Sophie, Daubry, Alison, Kahvecioglu, Zehra Cagla   +8 more
core