Results 121 to 130 of about 493,439 (210)

Tip60‐Mediated USP22 Lactylation Drives Glutamine Metabolic Reprogramming via SLC25A5 in TNBC

Advanced Science, EarlyView.
Tip60‐mediated USP22 K134 lactylation, stabilizing SLC25A5 to enhance glutamine metabolism and α‐KG secretion. The secreted α‐KG drives GPR91‐dependent M2 macrophage polarization, promoting triple‐negative breast cancer progression. Targeting this axis synergizes with CB‐839, offering a promising therapeutic strategy for TNBC.
Fang Zhen, Hongyi Wang, Ningzhi Zhang, Le Wang, Huiyuan Tian, Luxi Kang, Zhanpeng Liu, Jing Hu   +7 more
wiley   +1 more source

UACR adjustment attenuates associations of selected routine blood markers with documented diabetic retinopathy more than eGFR adjustment: a cross-sectional study in type 2 diabetes. [PDF]

Front Endocrinol (Lausanne)
Zhang J, Xu M, Xiong B, Luo B, Pang L.
europepmc   +1 more source

Loss of Lepr in Fibroblasts Drives Tumor Development by Promoting Macrophage Infiltration

Advanced Science, EarlyView.
TNFα and TGFβ signaling reprograms Lepr+ fibroblasts toward a LeprnegMmphigh inflammatory CAF (iCAF) state, with downregulation of the Tcf21‐Lepr axis contributing to this transition. Lepr loss induces Csf3, which contributes to the enhanced macrophage‐recruiting capacity of these iCAFs, thereby promoting tumor development. Thus, inflammatory signaling
Manyu Song, Wuqi Yang, Bangran Qi, Liyuan Hou, Xu Yang, Jiuzhi Xu, Shengyuan Tian, Shuiling Jin, Lu Yu, Zhengquan Yu, Min Deng, Jiaqiang Huang, Suoqin Jin, Cong Lv   +13 more
wiley   +1 more source

BLU-451, a CNS-Active, Potent, and Selective Small-Molecule Inhibitor against Uncommon EGFR Mutations. [PDF]

Mol Cancer Ther
Millet YA, Spira AI, Baik CS, Hong MH, Shum E, Patel JD, Nguyen D, Jänne PA, Piotrowska Z, Leighl NB, Matsumoto S, Sun L, Yang TY, Yoshida T, Nilsson MB, Heymach JV, Murray BW, Keats J, Lee S, Hsieh J, Zalutskaya A, Le X.   +21 more
europepmc   +1 more source

Fully Integrated Wearable Ultrasound System for Continuous Promotion of Wound Healing

Advanced Science, EarlyView.
A wearable ultrasound system integrating a drug‐loaded patch and a miniaturized driving circuit is presented to achieve noninvasive, on‐demand stimulation, enabling programmable antibacterial activity, inflammation modulation, and accelerated wound closure through enhanced cell migration and collagen remodeling.
Faxing Zou, Yansen Wang, Yong Luo, Wenxuan Zhuang, Mingyu Zhu, Min Long, Qingzhou Liu, Tailin Xu   +7 more
wiley   +1 more source

CT-based prediction of <i>EGFR</i> mutation subtypes and <i>TP53</i> co-mutation status in lung adenocarcinoma. [PDF]

Front Mol Biosci
Liu H, Li Z, Zhang Y, Yu G, Miao Y, Teng X, Xu Y, Xu W, Gao C, Bai F, Li L.   +10 more
europepmc   +1 more source

Bioorthogonal Click‐to‐Disassemble Phthalocyanine Nanoassemblies for Precise Chemo‐Photodynamic Therapy against Hypoxic Tumors

Advanced Science, EarlyView.
A bioorthogonal “click‐to‐disassemble” strategy enables precise activation of self‐assembled phthalocyanine nanoassemblies for chemo‐photodynamic therapy. EGFR‐targeted activator triggers IEDDA‐mediated disruption of the quenched assemblies, restoring fluorescence and ROS generation while releasing tirapazamine.
Jiaxin Shen, Evelyn Y. Xue, Caixia Yang, Peter Chi Keung Cheung, Dennis K. P. Ng   +4 more
wiley   +1 more source

Disparities in Treatment Patterns for Advanced ALK- and EGFR-Mutated Non-Small Cell Lung Cancer Patients in Mexico. [PDF]

Thorac Cancer
Sanchez Trujillo LA, Díaz García DA, García-Appendini IC, Caballero N, Knape NR, Herrera SE, Olguin JF, Silva Julian G.   +7 more
europepmc   +1 more source

Kidney Health Biomarkers and Estimated Glomerular Filtration Rate Among Indonesian Tofu Production Workers: A Pilot Cross-Sectional Study. [PDF]

Health Sci Rep
Alayyannur PA, Wahyudiono YDA, Nadira A, Prasetyo RA, Wikurendra EA.   +4 more
europepmc   +1 more source

ALDH2 Deficiency Promotes Mitochondrial Oxidative Stress and Adverse Limb Outcomes via VDAC–HSP60 Signaling

Advanced Science, EarlyView.
ALDH2 deficiency promotes 4‐HNE accumulation, resulting in covalent modification of HSP60, disruption of its oligomeric assembly, and VDAC1‐dependent release of HSP60 from mitochondria to the cytosol. Pharmacological activation of ALDH2 preserves HSP60 proteostasis and mitochondrial integrity, whereas the clinical association between the ALDH2 rs671 ...
You‐Cheng Lin, Nan‐Chun Wu, Chon‐Seng Hong, Po‐Chao Hsu, Wen‐Jin Yang, Yi‐Cheng Chang, Che‐Hong Chen, Wei‐Ting Chang   +7 more
wiley   +1 more source