Results 141 to 150 of about 493,439 (210)

Context-Dependent Clinical Narrative Signals of Renal Function Deterioration in Cross-Language Settings: Retrospective Multicohort Study. [PDF]

JMIR Med Inform
Antonakis A, Drosataki E, Dermitzaki EK, Pleros C, Lygerou D, Androvitsanea A, Papadakis N, Kydonaki K, Kavvadias AG, Konidaki M, Aletras G, Pantazis Y, Gakiopoulou H, Stylianou K, Petrakis I.   +14 more
europepmc   +1 more source

Baihe Zhimu Decoction ameliorates anxious depression via PI3K/AKT/mTOR pathway‐mediated neuroprotection and inhibition of hippocampal neuronal apoptosis

Animal Models and Experimental Medicine, EarlyView.
Baihe Zhimu Decoction alleviates anxious depression‐like behaviors and protects hippocampal neurons. Chemical profiling and network pharmacology reveal multiple active components acting via the PI3K/AKT/mTOR pathway, enhancing neuronal survival and function, as confirmed by multi‐level in vitro and in vivo validation.
Yuanshan Han, Kexin He, Haolan Yang, Jiacheng Dai, Ronglin Chen, Yang Liu, Yuhong Wang, Lin Tang, Hongqing Zhao   +8 more
wiley   +1 more source

Growth Differentiation Factor 15 as a Cerebrospinal Fluid Biomarker for the Diagnosis and Prognosis of Leptomeningeal Metastasis

Annals of Neurology, EarlyView.
Objective As leptomeningeal metastasis (LM) has a poor prognosis, reliable cerebrospinal fluid (CSF) diagnostic biomarkers are urgently needed. This study evaluated the diagnostic value of CSF growth differentiation factor 15 (GDF15) in LM from lung adenocarcinoma (LUAD) and breast cancer (BC).
Haoyu Ruan, Jie Li, Fuhai Wang, Lei Zhang, Jie Luo, Yuan Mu, Ting Wang, Yuqing Wu, Jingping Liu, Yunyun Ning, Xuan Deng, Ming Guan, Jian Xu   +12 more
wiley   +1 more source

Age-Normalized Baseline Renal Function: A Simple Risk Marker in Coronary Artery Bypass Grafting. [PDF]

Biomedicines
Apaydın Z, Timur B, Akyol M, Güler S, Can İ, Kadiroğulları E.   +5 more
europepmc   +1 more source

Über die Bindungsstelle hinausgedacht: Ein sich selbsteinkapselnder Kinase‐Inhibitor modelliert seine Bindetasche und erzielt so Selektivität

Angewandte Chemie, EarlyView.
Um außergewöhnlich wirksame Wirkstoffe zu entwickeln, ist es erforderlich, über die Bindungsstelle hinaus zu denken. Diese Arbeit zeigt, dass die auf den ersten Blick kontraintuitive Adressierung einer konservierten Region der Kinase zu einer hochselektiven Bindung führen kann.
Nico J. Seidler, Monica R. MacDonald, Athina A. Moschopoulou, Sahba Cunningham, Tess M. Weber, Nader N. Nasief, Lorenz Mayer, Frederik W. Hacker, Ekaterina Hermann, Mareike B. Möllers, Yuliia Skliarenko, Tahereh Damghani, Abid N. Manzar, Kaly S. Lin, Ramona Rudalska, Marcia I. Goettert, Lars Zender, Daniel Dauch, Michael Forster, Stefan A. Laufer, David E. Heppner   +20 more
wiley   +1 more source

Panitumumab-Based EGFR Blockade in SMARCB1-Deficient Renal Medullary Carcinoma: Preclinical Basis and Prospective Clinical Activity. [PDF]

Clin Cancer Res
Zacharias NM, Rupe ES, Chen X, Kotecha RR, Rieke DT, McGregor BA, Pesquera P, Yu Z, Grover A, Daw NC, Wang E, Chan SWS, Douglas-Lindsay D, Fan AC, Knoche EM, Kyriakopoulos CE, Lalani AA, Mantia CM, Merla A, Voss MH, Pfanzelter N, Ramakrishna S, Reaume NM, Tang T, Ingram DR, Shamsutdinova D, Wani KM, Wang WL, Lazar AJ, Sheth RA, Rao P, Grimm SL, Coarfa C, He R, Qian J, Duan F, Bisht D, Chauhan PK, Perelli L, Genovese G, Yang L, Lin C, Karam JA, La Posta L, Dondossola E, Basar R, Uprety N, Rezvani K, Gao J, Wang L, Solis Soto LM, Lim B, Tannir NM, Karki M, Msaouel P.   +54 more
europepmc   +1 more source

Oncogenic mutations in non-small cell lung cancer: from molecular mechanisms to clinical practice. [PDF]

Signal Transduct Target Ther
Li C, Yin X, Zhou S, Wen J, Yu J, Meng X.   +5 more
europepmc   +1 more source

Click‐Spaltung quartärer Anilinium‐Tetrazine ermöglicht Kaskadenaufbau multifunktioneller biomolekularer Gerüste

Angewandte Chemie, EarlyView.
Die Click‐Chemie hat sich von dem Aufbau kovalenter Bindungen hin zum Spalten von Bindungen weiterentwickelt. Hier wird über einen Kaskaden‐Aufbau berichtet, der diese Verfahren kombiniert, um multifunktionale biomolekulare Gerüste in einer modularen Ein‐Topf‐Reaktion aufzubauen.
Markus Staudt, Christian B. M. Poulie, Andreas Löffler, Peter R. Meinig, Riley J. Deutsch‐Williams, Barbara Herrmann, Ralph Weissleder, Hannes Mikula, Jonathan C. T. Carlson, Matthias M. Herth   +9 more
wiley   +1 more source

Synthesis, antitumor evaluation, and <i>in silico</i> investigation of pyridine-based pyrimidotriazine and triazolopyrimidine derivatives as potential EGFR-targeted anticancer agents. [PDF]

RSC Adv
Ramadan SK, Abdelrahman AH, Hegazy MA, Labena A, Gomha SM, Zaki MEA, Azab ME.   +6 more
europepmc   +1 more source

Thinking Outside the Binding Site: A Self‐Encapsulating Kinase Inhibitor Remodels Its Pocket to Achieve Selectivity

Angewandte Chemie International Edition, EarlyView.
To make exceptionally effective drugs, thinking “outside the binding site” is required. This work reveals that counterintuitive targeting of a kinase‐conserved region can lead to highly selective binding. Inhibitor discovery coupled to x‐ray crystallography shows that a network of noncanonical interactions and long‐range effects of distant unique amino
Nico J. Seidler, Monica R. MacDonald, Athina A. Moschopoulou, Sahba Cunningham, Tess M. Weber, Nader N. Nasief, Lorenz Mayer, Frederik W. Hacker, Ekaterina Hermann, Mareike B. Möllers, Yuliia Skliarenko, Tahereh Damghani, Abid N. Manzar, Kaly S. Lin, Ramona Rudalska, Marcia I. Goettert, Lars Zender, Daniel Dauch, Michael Forster, Stefan A. Laufer, David E. Heppner   +20 more
wiley   +1 more source