Results 271 to 280 of about 653,031 (357)

Development of a multimodal fully automated ensemble model to predict EGFR mutation and efficacy of EGFR-TKI in non-small cell lung cancer. [PDF]

Transl Lung Cancer Res
Xu S, Miyawaki T, Shukuya T, Suzuki K, Shimamura SS, Matsuda H, Kanemaru R, Asao T, Mimori T, Otsuka Y, Takahashi K.   +10 more
europepmc   +1 more source

Electronic Health Records to Test Multimorbidity Influences to Plasma Biomarker Interpretation for Alzheimer's Disease

Annals of Neurology, EarlyView.
Objective Plasma biomarkers of Alzheimer's disease (AD) pathology are frequently tested in specialized research settings, which limits the generalizability of findings. Using electronic health records and banked plasma, we evaluated plasma biomarkers—phosphorylated tau 217 (p‐tau217), β‐amyloid 1–42/1–40 (Aβ42/Aβ40) and p‐tau217/Aβ42—in a real‐world ...
Katheryn A.Q. Cousins, Rory Boyle, Colleen Morse, Anurag Verma, Christopher A. Brown, Kyra S. O'Brien, Marina Serper, Nadia Dehghani, Penn Medicine BioBank, Corey T. McMillan, Edward B. Lee, Leslie M. Shaw, David A. Wolk   +12 more
wiley   +1 more source

Discovery of a First‐in‐Class Covalent Allosteric SHP1 Inhibitor with Immunotherapeutic Activity

Angewandte Chemie, EarlyView.
A covalent allosteric inhibitor M029 was discovered for SHP1, a novel target for immunotherapy. M029 binds to a cryptic Cys remote from the active site, exhibits robust target engagement, and blocks tumor progression by stimulating antitumor immune response.
Zihan Qu, Frederick Nguele Meke, Zheng Zhang, Aaron D. Krabill, Christine S. Muli, Brenson A. Jassim, Jiajun Dong, Quyen D. Nguyen, Yunpeng Bai, Jinyue Li, Yiming Miao, Bardia Asadi, Levi M. Johnson, Jinmin Miao, Darci J. Trader, W. Andy Tao, Zhong‐Yin Zhang   +16 more
wiley   +2 more sources

Interactions of HRLCMS-QTOF Detected Plant Metabolites of <i>Abrus precatorius</i> L. Seeds with EGFR and the Effect of Classically Detoxification Process

E N T Vikram, R. Kamaraj, R. Ilavarasan
openalex   +1 more source

Correction: EGFR C797S, EGFR T790M and EGFR sensitizing mutations in non-small cell lung cancer revealed by six-color crystal digital PCR

, 2019
Jordan Madic, Cécile Jovelet, Julien Lopez, Barbara André, Jean Fatien, Isabelle Miran, Aurélie Honoré, Laura Mezquita, Benjamin Besse, Ludovic Lacroix, Magali Droniou   +10 more
openalex   +1 more source

Dynamischer Austausch von Bindemolekülen steigert die Effizienz der Proteinmarkierung in DNA‐PAINT um das bis zu 15‐Fache

Angewandte Chemie, EarlyView.
Der dynamische Austausch von Bindemolekülen (Dynamic Binder Exchange; DyBE) nutzt transiente Binde–Zielprotein‐Interaktionen, um die Markierungseffizienz in der superauflösenden Mikroskopie um das 15‐Fache zu steigern. DyBE kartiert die Organisation von Rezeptor‐Tyrosinkinasen (RTKs), einschließlich HER2‐Homodimere und EGFR–HER2‐Heterodimere, auf der ...
Clemens Steinek, Isabelle Pachmayr, Sebastian Strauss, Monique Honsa, Jisoo Kwon, Ralf Jungmann   +5 more
wiley   +1 more source

Prolonged survival in EGFR exon 20 insertion mutant lung adenocarcinoma: case report of sequential osimertinib and furmonertinib with research trend analysis. [PDF]

Front Med (Lausanne)
Lu Y, Zhao R, Wang N, Zhao J, Huang N, Al-Danakh A, Liu H, Gao P.   +7 more
europepmc   +1 more source

EGFR mutation

, 2019
Yuranga Weerakkody, Joshua Yap, Daniel Bell   +2 more
openaire   +1 more source

Ungesättigte Phosphor‐Elektrophile zur Untersuchung von Protein‐Tyrosin‐Phosphatasen

Angewandte Chemie, EarlyView.
Negativ geladene Aryl‐Ethynyl‐Phosphonamid‐ und Phosphonsäuren werden als reaktionsarme Elektrophile für peptidbasierte Aktivitätssonden eingeführt, die eine selektive, zielspezifische Profilierung von Protein‐Tyrosin‐Phosphatasen ermöglichen. Die Sonden zeigen keine Off‐Target‐Cystein‐Reaktivität und binden in der globalen Proteomanalyse nur an die ...
Eleftheria Poulou, Max Ruwolt, Christian E. Stieger, Kristin Kemnitz‐Hassanin, Christian P. R. Hackenberger   +4 more
wiley   +1 more source