Results 281 to 290 of about 447,577 (315)
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Nature Reviews Cancer, 2021
Gao, Xia, Li, Zhang et al. show that a circular RNA-encoded variant of E-Cadherin stimulates EGFR signalling independently of EGF, and contributes to glioblastoma tumorigenesis and anti-EGFR therapy resistance.
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Gao, Xia, Li, Zhang et al. show that a circular RNA-encoded variant of E-Cadherin stimulates EGFR signalling independently of EGF, and contributes to glioblastoma tumorigenesis and anti-EGFR therapy resistance.
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Clonal dominance of EGFR and efficacy of EGFR-tyrosine kinase inhibitors (EGFR-TKIs) in NSCLC.
Journal of Clinical Oncology, 2020e21501 Background: Though EGFR mutations in lung cancer are identified most often on the trunks of tumor phylogenetic trees in early stage, whether EGFR would always be the dominant clone in the advanced stage is unknown, as cancer evolution often follows a branched trajectory, with divergent subclones evolving simultaneously.
Xinghao Ai +14 more
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European Journal of Cancer, 2001
Elevated levels of the epidermal growth factor receptor (EGFR), a growth-factor-receptor tyrosine kinase, and/or its cognate ligands have been identified as a common component of multiple cancer types and appear to promote solid tumour growth. This article examines the relationship between EGFR expression and cancer prognosis based on literature ...
R I, Nicholson, J M, Gee, M E, Harper
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Elevated levels of the epidermal growth factor receptor (EGFR), a growth-factor-receptor tyrosine kinase, and/or its cognate ligands have been identified as a common component of multiple cancer types and appear to promote solid tumour growth. This article examines the relationship between EGFR expression and cancer prognosis based on literature ...
R I, Nicholson, J M, Gee, M E, Harper
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Anti-EGFR–mediated radiosensitization as a result of augmented EGFR expression
International Journal of Radiation Oncology*Biology*Physics, 2004Elevated epidermal growth factor receptor (EGFR) expression has correlated with a poor prognosis after standard treatment of several malignancies. However, it is not clear whether the absolute level of EGFR expression affects the radiosensitizing properties of anti-EGFR treatments. A better understanding of this question would be helpful for the design
James A, Bonner +6 more
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Applied Immunohistochemistry & Molecular Morphology, 2007
Immunohistochemistry is widely used to assess epidermal growth factor receptor (EGFR) expression on colorectal carcinomas to select patients for treatment with cetuximab, an anti-EGFR antibody. The data comparing different commercial EGFR antibodies is limited, and no cost comparisons have been made.
Anne F, Buckley, Sanjay, Kakar
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Immunohistochemistry is widely used to assess epidermal growth factor receptor (EGFR) expression on colorectal carcinomas to select patients for treatment with cetuximab, an anti-EGFR antibody. The data comparing different commercial EGFR antibodies is limited, and no cost comparisons have been made.
Anne F, Buckley, Sanjay, Kakar
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EGFR mutations and EGFR tyrosine kinase inhibitors
The Lancet Oncology, 2015Valter, Torri +2 more
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Lung Cancer
In EGFR-mutated lung adenocarcinoma (EGFRm LUAD), EGFR mutations do not necessarily result in increased EGFR expression (EGFR-exp), which differs among patients. However, the factors influencing EGFR-exp and the impact of EGFR-exp on tumor characteristics in patients with EGFRm LUAD remain unclear.Whole-exome and RNA sequencing were performed for ...
Masahiro Torasawa +23 more
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In EGFR-mutated lung adenocarcinoma (EGFRm LUAD), EGFR mutations do not necessarily result in increased EGFR expression (EGFR-exp), which differs among patients. However, the factors influencing EGFR-exp and the impact of EGFR-exp on tumor characteristics in patients with EGFRm LUAD remain unclear.Whole-exome and RNA sequencing were performed for ...
Masahiro Torasawa +23 more
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CD70 is a therapeutic target upregulated in EMT-associated EGFR tyrosine kinase inhibitor resistance
Cancer Cell, 2023Yukie Kashima +2 more
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