Results 311 to 320 of about 785,489 (353)

Kidney function trajectories before and after hospitalization for heart failure with reduced ejection fraction. [PDF]

Eur Heart J
Kobayashi M, Bayes-Genis A, Duarte K, McMurray JJV, Ferreira JP, Pocock SJ, Van Veldhuisen DJ, Lupón J, Pitt B, Zannad F, Girerd N.   +10 more
europepmc   +1 more source

Orchestration of Skin Pathology in Cutaneous Lupus Erythematosus by HLA Class I Down‐Regulated Senescent Epidermal Basal Cells

Arthritis &Rheumatology, EarlyView.
Objective This study investigates the role of senescent epidermal basal cells in cutaneous lupus erythematosus (CLE) pathogenesis using skin samples from patients with CLE and a mouse model of systemic lupus erythematosus (SLE). Methods Cellular senescence profiling used datasets from the NCBI GEO database and Accelerating Medicines Partnership (AMP ...
Sena Yamamoto, Yuki Saito, Tsukasa Sato, Seina Nakano, Dain Kasseki, Ayaka Nagao, Norihiro Miura, Kentaro Nagaoka, Arisa Kita, Maki Miyajima, Shogo Ijima, Koji Taniguchi, Atsushi Niida, Takako S. Chikenji   +13 more
wiley   +1 more source

First-Line Third-Generation EGFR Tyrosine Kinase Inhibitor Monotherapy for Advanced EGFR-Mutated Non-Small Cell Lung Cancer: A Systematic Review and Network Meta-Analysis. [PDF]

MedComm (2020)
Du W, Li A, Xiao B, Yang Y, Fang W, Huang Y, Hong S, Zhang L.   +7 more
europepmc   +1 more source

Efficacy and Safety of Dotinurad Versus Febuxostat for the Treatment of Gout: A Randomized, Multicenter, Double‐Blind, Phase 3 Trial in China

Arthritis &Rheumatology, EarlyView.
Objective Dotinurad is a selective urate reabsorption inhibitor that reduces serum urate levels. We compared the efficacy and safety of dotinurad with febuxostat in Chinese patients with gout. Methods This phase 3, multicenter, randomized, double‐blind, parallel‐group study randomly allocated (1:1) eligible patients with gout to receive oral dotinurad ...
Jia Sun, Yu Wang, Yongjing Cheng, Dongmei Guo, Jiankang Hu, Dongzhou Liu, Zhengnan Gao, Changgui Li, Yibing Lu, Xiaodan Kong, Yu Liu, Zhenyu Jiang, Bin Yi, Hongfeng Zhang, Baijie Xu, Shihao Yu, Rieko Kokan, Kohei Ishikawa, Mikiko Kawakatsu, Zhuoli Zhang   +19 more
wiley   +1 more source

Distinct survival, optimal combination strategy of immunotherapy, and immunophenotype in uncommon and 20ins EGFR-mut lung adenocarcinoma: a multi-center study. [PDF]

Mol Biomed
Sun Y, Xu L, Deng C, Du X, Yu Y, Hao Y, Wang H, Wang X, Zhang Y, Chen H.   +9 more
europepmc   +1 more source

Biomarkers of Lupus Nephritis Histopathology: Where Do We Stand?

Arthritis &Rheumatology, Accepted Article.
Objective Lupus nephritis (LN) is characterized by a variable disease course, necessitating continuous monitoring. There is an urgent need to identify non‐invasive biomarkers. By reviewing and critically assessing the quality of existing studies on LN biomarkers correlating with histopathology, we here explore the challenges in promoting their use in ...
Valentina Querin, Leonardo Palazzo, Agnes B. Fogo, Mark Haas, David R. W. Jayne, Liz Lightstone, Brad H. Rovin, Surya V. Seshan, Augusto Vaglio, Ioannis Parodis, Ingeborg M. Bajema, The LN classification steering committee   +11 more
wiley   +1 more source

Hepatocyte-specific epidermal growth factor receptor (EGFR) deletion attenuates acetaminophen-induced liver injury in mice. [PDF]

Toxicol Sci
Jain S, Williams G, Mukherjee R, Orr A, Liu JJ, Liu S, Locker J, Bhushan B.   +7 more
europepmc   +1 more source

Enzyme‐Instructed Self‐Assembly for Cellular Supramolecular Chemistry

Chemistry – An Asian Journal, EarlyView.
Enzyme‐instructed self‐assembly (EISA) harnesses cellular enzymes to program supramolecular architectures in living systems, opening a new frontier for intelligent therapeutics, adaptive materials, and synthetic cellular design. ABSTRACT Enzyme‐instructed self‐assembly (EISA) uses endogenous enzymatic activity to convert soluble precursors into self ...
Yali Huang, Xingjie Hu, Zhimou Yang, Bing Xu   +3 more
wiley   +1 more source

Activating NEDD4L suppresses EGFR-driven lung adenocarcinoma growth via facilitating EGFR proteasomal degradation. [PDF]

J Exp Clin Cancer Res
Chen M, Jiang W, Zhan J, Zhang S, Zheng J, Huang Y, He J, Yang Y, Zhao S, Zhang Y, Liu J, Pang L, Zhang L, Fang W, Li J.   +14 more
europepmc   +1 more source

5‐Methylcytosine Analysis of miRNAs in Minimal Change Disease

Biotechnology and Applied Biochemistry, EarlyView.
ABSTRACT Minimal change disease (MCD) is a glomerular disorder, which is the most common cause of nephrotic syndrome in children. Additionally, the prevalence of MCD in adults has been increasing in recent years. During protein synthesis, noncoding RNAs can be regulated through a variety of modifications, which helps preserve biological diversity and ...
Huiyi Zeng, Dandan Li, Yunyi Li, Chen Yun, Xinzhou Zhang, Wenyu Gong, Mengyun Xiao, Haitao Li, Zhipeng Zeng, Ruqi Tan, Yishen Yang, Shaodong Luan, Yong Dai, Lianghong Yin, Donge Tang   +14 more
wiley   +1 more source