Results 131 to 140 of about 1,254,146 (342)

Targeting DESI2 as a Novel Therapeutic Strategy for JAK2‐Mutant Leukemias

open access: yesAdvanced Science, EarlyView.
Mass spectrometry‐based proteomics identify DESI2 as a novel component of the JAK2‐V617F complex, which associates with and stabilizes mutant JAK2 through deSUMOylation and deubiquitination, therefore promoting JAK2 mutant cell growth and MPN disease onset in vivo.
Husheng Mei   +32 more
wiley   +1 more source

Hatching and viability of rotifer diapausing eggs collected from pond sediments [PDF]

open access: bronze, 2006
Eduardo M. García‐Roger   +2 more
openalex   +1 more source

cDC1 Subtype‐Specific In Vivo Targeting of Liposomes

open access: yesAdvanced Science, EarlyView.
Dendritic cells, particularly the cDC1 subtype, offer a promising target for drug delivery via liposomes due to their pivotal role in immune regulation, allowing for amplified therapeutic responses. Herein, we show an integration of physicochemical characterization and cell experiments to achieve effective in vivo cDC1 targeting through anti‐CLEC9A ...
Maximilian Schaaf   +11 more
wiley   +1 more source

Cryostorage-induced water dynamics in whole egg liquid gels: macrostructural transformations and molecular dehydration mechanisms

open access: yesFood Chemistry: X
Frozen whole egg liquid (FWEL) offers convenience and extended shelf life, yet frozen storage leads to water loss and quality deterioration during subsequent thermal processing.
Bing Li   +8 more
doaj   +1 more source

Mendelian Randomization and Double Machine Learning Modeling Reveal Brain Imaging‐Derived Phenotypes as Functional Contributors to 18 Autoimmune Inflammatory Diseases

open access: yesAdvanced Science, EarlyView.
This schematic integrates the eight statistically significant causal relationships identified between 1,366 brain imaging‐derived phenotypes (IDPs) and 18 autoimmune inflammatory diseases (AIDs). Arrows indicate the direction of causality inferred from bidirectional two‐sample MR analyses.
Jinbin Chen   +8 more
wiley   +1 more source

Good eggs and bad eggs [PDF]

open access: yesAmerican Journal of Obstetrics and Gynecology, 2016
openaire   +2 more sources

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