Results 71 to 80 of about 41,293 (267)

Alternative Developmental Toxicity Screening Methods Using Chick Embryo‐Based Models

Journal of Applied Toxicology, EarlyView.
ABSTRACT Nonclinical developmental toxicity studies are used to investigate the potential toxicities of drugs and chemical candidates on normal embryonic and fetal development during pregnancy, generally using mammalian laboratory animals such as rats and rabbits.
Jeong Hwan Kim, Cheoljin Park, Donghee Kim, Wonjun Jeong, Jinsoo Lee   +4 more
wiley   +1 more source

New Hydrazone Derivatives Featuring Isatin and Piperazine Moieties: Synthesis, Cytotoxicity Evaluation, and Molecular Modeling Studies

Journal of Applied Toxicology, EarlyView.
ABSTRACT In this study, ten novel compounds (IPH1–IPH10) were designed by integrating three pharmacophores (isatin, piperazine, and hydrazone) commonly found in the molecular structures of anticancer agents. The target molecules were obtained by the reaction of in‐house prepared 4‐(4‐(pyridin/pyrimidin‐2‐yl)piperazin‐1‐yl)benzohydrazide with various ...
Semiha Köprü, Münevver Baran, Miyase Gözde Gündüz, Şengül Dilem Doğan   +3 more
wiley   +1 more source

Nanoplastics: Methods, Exposure and Effects on Domestic, Farm and Wild Animals

Journal of Applied Toxicology, EarlyView.
ABSTRACT Nanoplastics (NPs) are synthetic polymer particles ranging in size from 1 nm to 1 μm that have been identified as a major concern for ecosystems and organisms due to their plethora of negative effects. The aim of this review is to provide a comprehensive overview of the knowledge relating to exposure and effects of NPs in domestic (i.e., farm ...
B. De Felice, M. Bertazzo, A. F. Tabaran, M. Parolini, R. P. Popa, A. Pintea, L. J. Spicer, A‐L. Nagy, F. Caloni   +8 more
wiley   +1 more source

A Comparison of Egg Yolk-Sodium Citrate, Egg Yolk-Sodium Citrate-Glycine, and Egg Yolk-Glycine as Semen Diluters

Journal of Dairy Science, 1958
Summary The average length of time that a +3 motility was maintained in egg yolk-citrate-glycine, egg yolk-glycine, and egg yolk-citrate, was 14.7, 13.9, and 6.8 days, respectively, for bovine sperm; 6.8, 8.8, and 3.5 days, respectively, for buffalo sperm; and 17.2, 8.0, and 4.4 days for ram sperm.
S.K. Saha, R.B. Singh
openaire   +1 more source

Calpain Proteases and the Evolving Signaling Network in Insect Embryonic Patterning

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.
Insect embryonic Dorsal‐Ventral (DV) patterning relies on the BMP and Toll pathways to different extents. Calcium‐dependent cystein proteases of the Calpain family also exert an important function to pattern the DV axis. In Drosophila, Calpain A cleaves the Cactus/IkappaB inhibitor and modifies Toll signals in ventral regions of the embryo. In Rhodnius
Alison Julio, Helena Araujo
wiley   +1 more source

Egg Yolk Protective Effect in Boar Spermatozoa Cooled at 5ºC

Scientific Papers Animal Science and Biotechnologies, 2023
Nowadays, many boar reproduction researches are directed to improve extenders and to increase cold shock protection of semen. Little research is focused on the influence of egg yolk combined with alternative cold shock protective media.
Alexandru-Vasile Rusu, Vasile Miclea, Marius Zahan   +2 more
doaj  

Development of an Efficient and Scalable Process for Preparing Timolol N‐Nitrosamine Impurities B, C, E, H, I, J, and Their ADMET Evaluation

Journal of Heterocyclic Chemistry, EarlyView.
N‐nitrosamine impurities (B, C, E, H, I, J) of timolol maleate are easily synthesized from diethyl malonate and 3,4‐dichloro‐1,2,5‐thiadiazole. Good yields and precise impurity profiling are made possible by the effective technique, which also ensures pharmaceutical safety and strengthens regulatory compliance.
Kottolla Sai Prasad, Chithaluri Sudhakar, Vijaya Krishna Ravi, Bijaya Kethan Sahoo   +3 more
wiley   +1 more source

The planktonic food web in the Gulf of Naples based on the analysis of carbon and nitrogen stable isotope ratios

Marine Ecology, EarlyView., 2023
Abstract Plankton play a key role in marine food webs by producing and transferring organic matter and energy to higher trophic levels. To define the trophic structure and interactions within the planktonic communities in the Gulf of Naples, we determined carbon and nitrogen stable isotope ratios in particulate organic matter (POM, <20 μm ...
Louise Merquiol, Maria Grazia Mazzocchi, Isabella D'Ambra   +2 more
wiley   +1 more source

Maintaining egg freshness in the absence of refrigeration: The potential of zero‐energy cooling pots

JSFA reports, EarlyView.
Abstract Background Egg storage in regions with unreliable electricity is challenging, leading to rapid quality deterioration and postharvest losses. This study evaluated the efficacy of a Zero‐Energy Cooling (ZEC) pot, an evaporative cooling technology, for preserving table egg quality in comparison to conventional refrigeration and ambient storage ...
Thomas Ansong Agyei, Kruenti Francis, Maxwell Ansong Okai, Edmund Sottie, Gameli Kafui Apedo   +4 more
wiley   +1 more source

Evaluating the combined toxicity of Penicillium mycotoxins in absorption, metabolism, and excretion systems

Journal of the Science of Food and Agriculture, EarlyView.
Abstract BACKGROUND Penicillium mycotoxins, including ochratoxin A (OTA), citrinin (CIT), and cyclopiazonic acid (CPZ), frequently co‐occur in food commodities, contributing to chronic low‐level dietary exposure. However, current risk assessments often consider these toxins individually, overlooking potential interaction effects.
Carolina Sousa Monteiro, Eugénia Pinto, Miguel A Faria, Sara C Cunha   +3 more
wiley   +1 more source