Results 81 to 90 of about 656,973 (277)
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
Spirituality Studies, 2021 In his essay, the author provides a brief consideration on the fundamentals of an authentic spirituality in the context of his lifelong spiritual practice.
Jiří Vacek
doaj
Aspectos diferenciais da noção de ego e de self na obra de Winnicott
Estilos da Clínica, 2014 Nesse artigo pretende-se mostrar qual sentido e referente Winnicott atribuiu aos termos self e ego. Ainda que Winnicott não tenha usado esses termos de maneira clara e distinta ao longo de sua obra, procura-se demonstrar que, num momento mais maduro, ele
Leopoldo Fulgenci
doaj +1 more source
Leader reputation and default in sovereign debt [PDF]
, 2009 This paper compares default incentives in competitive sovereign debt markets when leaders can be either democratically elected or dictators. When leaders can be replaced as in democracies, the incentives for repayment are mainly the ego rents from office
Dhillon, Amrita, Sjöström, Tomas
core +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Filhos da mãe - Animus da mãe na vida do filho
Self, 2019 Este artigo tem por objetivo refletir sobre as pessoas nascidas no contexto da ausência paterna, os “filhos da mãe”. A partir do entendimento do inestimável valor do fenômeno relacional humano e do funcionamento psíquico, este trabalho aplica os ...
Irene Pereira Gaeta
doaj +1 more source
Ego-Downward and Ambient Video based Person Location Association
, 2018 Using an ego-centric camera to do localization and tracking is highly needed for urban navigation and indoor assistive system when GPS is not available or not accurate enough.
Huo, Zhouyuan +3 more
core +1 more source
BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma
FEBS Open Bio, EarlyView.The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru +6 more
wiley +1 more source