Results 51 to 60 of about 6,434 (146)

Drug Design and Delivery for Intracellular Bacteria: Emerging Paradigms

Drug Development Research, Volume 86, Issue 8, December 2025.
ABSTRACT Intracellular bacteria exploit host cell niches, such as lysosomes, phagosomes, cytosol, entire cells, and even erythrocytes, to evade immune clearance and escape conventional antibiotics. These environments pose numerous therapeutic challenges, including crossing host cell membranes, navigating endosomal trafficking, tolerating acidic and ...
Babatunde Ibrahim Olowu, Maryam Ebunoluwa Zakariya, Abdulmuheez Abiola Abdulkareem, Olalekan Toheeb Okewale, Muhammad Halima Idris, Halimah Oluwayemisi Olayiwola   +5 more
wiley   +1 more source

Ehrlichia chaffeensis TRP75 Interacts with Host Cell Targets Involved in Homeostasis, Cytoskeleton Organization, and Apoptosis Regulation To Promote Infection

mSphere, 2018
Ehrlichia chaffeensis is an obligately intracellular bacterium that exhibits tropism for mononuclear phagocytes. The mechanisms involved in E. chaffeensis infection of the host cell and evasion of host defenses are not fully defined, but a subset of type
Tian Luo, Shubhajit Mitra, Jere W. McBride   +2 more
doaj   +1 more source

Ecological dynamics of blacklegged ticks, vertebrate hosts, and associated zoonotic pathogens in northeastern forests

Ecosphere, Volume 16, Issue 12, December 2025.
Abstract Specific host‐tick interactions in temperate forest systems influence variation in density and infection prevalence of nymphal blacklegged tick (Ixodes scapularis). The density of infected nymphs (DIN), which is the product of nymphal infection prevalence (NIP) and density of questing nymphs (DON), influences the risk of human exposure to tick‐
Shannon L. LaDeau, Kelly Oggenfuss, Alexander Schmidt, Saravanan Thangamani, Richard S. Ostfeld   +4 more
wiley   +1 more source

Rickettsiales in Ticks Removed from Outdoor Workers, Southwest Georgia and Northwest Florida, USA

Emerging Infectious Diseases, 2019
We determined the prevalence of selected Rickettsiales in 362 ticks removed from outdoor workers in southwest Georgia and northwest Florida, USA. Persons submitted an average of 1.1 ticks/month.
Elizabeth R. Gleim, L. Mike Conner, Galina E. Zemtsova, Michael L. Levin, Pamela Wong, Madeleine A. Pfaff, Michael J. Yabsley   +6 more
doaj   +1 more source

A Case of Illness Following a Bite by a Male Lone Star Tick (Amblyomma americanum Linnaeus) Infected With Ehrlichia sp. and Rickettsia amblyommatis in Connecticut, United States

Clinical Case Reports, Volume 13, Issue 9, September 2025.
A case of local lymphadenopathy and a flu‐like illness in a man, following a bite by a male lone star tick infected with Ehrlichia sp. and Rickettsia amblyommatis. ABSTRACT The lone star tick (Amblyomma americanum Linnaeus) is a species commonly found in the southeastern U.S., but in recent years its populations have expanded northward, resulting in an
Noelle Khalil, Abigail Chang, Lorelei Sandland, Henry M. Feder Jr., Goudarz Molaei   +4 more
wiley   +1 more source

Development and Clinical Validation of a Multiplex Real-Time Quantitative PCR Assay for Human Infection by Anaplasma phagocytophilum and Ehrlichia chaffeensis

Tropical Medicine and Infectious Disease, 2018
Background: Human granulocytic anaplasmosis (HGA), caused by Anaplasma phagocytophilum, and human monocytic ehrlichiosis (HME), caused by Ehrlichia chaffeensis, often present as undifferentiated fever but are not treated by typical empiric regimens for ...
Megan E. Reller, J. Stephen Dumler
doaj   +1 more source

Distribution of tick-borne diseases in China [PDF]

, 2013
As an important contributor to vector-borne diseases in China, in recent years, tick-borne diseases have attracted much attention because of their increasing incidence and consequent significant harm to livestock and human health.
Hong-Juan Peng, Jin-Song Zhu, Ren-Hua Na, Shan-Shan Wei, Xian-Bo Wu   +4 more
core   +1 more source

Descriptive Analysis and Factors Associated With Relapse in Dogs With Presumptive Idiopathic Immune‐Mediated Polyarthritis

Journal of Veterinary Internal Medicine, Volume 39, Issue 5, September/October 2025.
ABSTRACT Background Immune‐mediated polyarthritis (IMPA) is a joint disease common in dogs. Although its prognosis is generally favorable, relapses are frequent, and predictive factors for relapse remain poorly characterized. Objectives To evaluate the outcome of medical management of IMPA in dogs and identify predictive factors for relapse.
Diane Pichard, Thibaud Robin, Kevin Le Boedec, Christelle Maurey, Maxime Kurtz, Fiona Da Riz, Stéphane Blot, Morgane Canonne‐Guibert, Mario Cervone, Emilie Krafft, Jean‐Luc Cadore, Loïc Desquilbet, Ghita Benchekroun   +12 more
wiley   +1 more source

Naturally Occurring Ehrlichia chaffeensis Infection in Coyotes from Oklahoma

Emerging Infectious Diseases, 2000
A nested polymerase chain reaction assay was used to determine the presence of Ehrlichia chaffeensis, E. canis, and E. ewingii DNA in blood samples of free-ranging coyotes from central and north-central Oklahoma. Of the 21 coyotes examined, 15 (71%) were
Alan Kocan, Gena Crowder Levesque, Lisa C. Whitworth, George L. Murphy, Sidney A. Ewing, Robert W. Barker   +5 more
doaj   +1 more source

Brucella canis in two juvenile labrador retriever littermates with no known travel history

Veterinary Record Case Reports, Volume 13, Issue 2, June 2025.
Abstract Two labrador retriever littermates presented separately to investigate chronic lethargy and shifting lameness. In both cases, clinical examination revealed a multi‐limb lameness. Neither the patients nor their dam or sire had a travel history outside the UK.
Amy Lord, Oliver Russell, Ombeline McGregor, Robert Dudley, Cassia Hare, Barbara Skelly   +5 more
wiley   +1 more source