Results 41 to 50 of about 9,885 (133)

Hacker Within! Ehrlichia chaffeensis Effector Driven Phagocyte Reprogramming Strategy

Frontiers in Cellular and Infection Microbiology, 2016
Ehrlichia chaffeensis is a small, gram negative, obligately intracellular bacterium that preferentially infects mononuclear phagocytes. It is the etiologic agent of human monocytotropic ehrlichiosis (HME), an emerging life-threatening tick-borne zoonosis.
Taslima Taher Lina, Tierra eFarris, Tian eLuo, Shubhajit eMitra, Bing eZhu, Jere W McBride   +5 more
doaj   +3 more sources

Ehrlichia chaffeensis TRP120-mediated ubiquitination and proteasomal degradation of tumor suppressor FBW7 increases oncoprotein stability and promotes infection. [PDF]

PLoS Pathog, 2020
Ehrlichia chaffeensis (E. chaffeensis) exploits evolutionarily conserved Notch and Wnt host cell signaling pathways to downregulate innate immune host defenses and promote infection. The multifunctional E.
Wang JY, Zhu B, Patterson LL, Rogan MR, Kibler CE, McBride JW.   +5 more
europepmc   +2 more sources

Anaplasmataceae closely related to Ehrlichia chaffeensis and Neorickettsia helminthoeca from birds in Central Europe, Hungary. [PDF]

Antonie Van Leeuwenhoek, 2020
Increasing amount of data attest that (in the context of vector-borne infections) birds are not only important as hosts of blood-sucking arthropod vectors, but also as reservoirs of vector-borne pathogens. From 2015 to 2019 cadavers of 100 birds (from 45
Hornok S, Hornok S, Boldogh SA, Takács N, Juhász A, Kontschán J, Földi D, Koleszár B, Morandini P, Gyuranecz M, Szekeres S.   +10 more
europepmc   +2 more sources

Multiple Ehrlichia chaffeensis Genes Critical for Its Persistent Infection in a Vertebrate Host Are Identified by Random Mutagenesis Coupled with In Vivo Infection Assessment. [PDF]

Infect Immun, 2020
Ehrlichia chaffeensis, a tick-transmitted obligate intracellular rickettsial agent, causes human monocytic ehrlichiosis. In recent reports, we described substantial advances in developing random and targeted gene disruption methods to investigate the ...
Wang Y, Nair ADS, Alhassan A, Jaworski DC, Liu H, Trinkl K, Hove P, Ganta CK, Burkhardt N, Munderloh UG, Ganta RR.   +10 more
europepmc   +2 more sources

Development and Clinical Validation of a Multiplex Real-Time Quantitative PCR Assay for Human Infection by Anaplasma phagocytophilum and Ehrlichia chaffeensis

Tropical Medicine and Infectious Disease, 2018
Background: Human granulocytic anaplasmosis (HGA), caused by Anaplasma phagocytophilum, and human monocytic ehrlichiosis (HME), caused by Ehrlichia chaffeensis, often present as undifferentiated fever but are not treated by typical empiric regimens for ...
Megan E. Reller, J. Stephen Dumler
doaj   +3 more sources

Ehrlichia chaffeensis and E. canis hypothetical protein immunoanalysis reveals small secreted immunodominant proteins and conformation-dependent antibody epitopes. [PDF]

NPJ Vaccines, 2020
Immunomolecular characterization of Ehrlichia chaffeensis (E. ch.) and E. canis (E. ca.) has defined protein orthologs, including tandem repeat proteins (TRPs) that have immunodominant linear antibody epitopes.
Luo T, Patel JG, Zhang X, Walker DH, McBride JW.   +4 more
europepmc   +2 more sources

Human Case of Ehrlichia chaffeensis Infection, Taiwan. [PDF]

Emerg Infect Dis, 2019
In 2018, an immunosuppressed woman in southern Taiwan had onset of fever, chills, myalgia, malaise, thrombocytopenia, lymphocytopenia, and elevated hepatic transaminases. Investigation revealed infection with Ehrlichia chaffeensis.
Peng SH, Yang SL, Ho YN, Chen HF, Shu PY.   +4 more
europepmc   +2 more sources

Proteomic analysis of the Ehrlichia chaffeensis phagosome in cultured DH82 cells. [PDF]

PLoS ONE, 2014
Ehrlichia chaffeensis is an obligately intracellular bacterium that resides and multiplies within cytoplasmic vacuoles of phagocytes. The Ehrlichia-containing vacuole (ECV) does not fuse with lysosomes, an essential condition for Ehrlichia to survive ...
Yan Cheng, Yan Liu, Bin Wu, Jian-zhi Zhang, Jiang Gu, Ya-ling Liao, Fu-kun Wang, Xu-hu Mao, Xue-jie Yu   +8 more
doaj   +1 more source

Comparative Analysis of Genome of Ehrlichia sp. HF, a Model Bacterium to Study Fatal Human Ehrlichiosis

BMC Genomics, 2021
Background The genus Ehrlichia consists of tick-borne obligatory intracellular bacteria that can cause deadly diseases of medical and agricultural importance. Ehrlichia sp. HF, isolated from Ixodes ovatus ticks in Japan [also referred to as I.
Mingqun Lin, Qingming Xiong, Matthew Chung, Sean C. Daugherty, Sushma Nagaraj, Naomi Sengamalay, Sandra Ott, Al Godinez, Luke J. Tallon, Lisa Sadzewicz, Claire Fraser, Julie C. Dunning Hotopp, Yasuko Rikihisa   +12 more
doaj   +1 more source

Mathematical model of Ehrlichia chaffeensis transmission dynamics in dogs

Journal of Biological Dynamics, 2023
Ehrlichia chaffeensis is a tick-borne disease transmitted by ticks to dogs. Few studies have mathematical modelled such tick-borne disease in dogs, and none have developed models that incorporate different ticks' developmental stages (discrete variable ...
F. Agusto, R. Djidjou-Demasse, O. Seydi
semanticscholar   +1 more source