Results 51 to 60 of about 9,793 (167)

Experimental Ehrlichia chaffeensis infection in beagles [PDF]

Journal of Medical Microbiology, 2003
A canine model for human monocytic ehrlichiosis was used to assess persistent infection and antigenic variation of Ehrlichia chaffeensis. Two beagle dogs were infected subcutaneously with E. chaffeensis Arkansas strain. The dogs were observed for 6 months after inoculation for clinical signs, blood chemistry changes, antibodies to E.
Xiao-Feng, Zhang, Jian-Zhi, Zhang, S Wesley, Long, Randall P, Ruble, Xue-Jie, Yu   +4 more
openaire   +2 more sources

Comparative Analysis of Genome of Ehrlichia sp. HF, a Model Bacterium to Study Fatal Human Ehrlichiosis

BMC Genomics, 2021
Background The genus Ehrlichia consists of tick-borne obligatory intracellular bacteria that can cause deadly diseases of medical and agricultural importance. Ehrlichia sp. HF, isolated from Ixodes ovatus ticks in Japan [also referred to as I.
Mingqun Lin, Qingming Xiong, Matthew Chung, Sean C. Daugherty, Sushma Nagaraj, Naomi Sengamalay, Sandra Ott, Al Godinez, Luke J. Tallon, Lisa Sadzewicz, Claire Fraser, Julie C. Dunning Hotopp, Yasuko Rikihisa   +12 more
doaj   +1 more source

Ultrastructural variation of cultured Ehrlichia chaffeensis [PDF]

Journal of Medical Microbiology, 1995
The ultrastructure of Ehrlichia chaffeensis (Arkansas strain) was studied in non-irradiated and irradiated monolayers of mouse embryo, Vero, BGM and L929 cells, and in non-irradiated DH82 cells. Within the intracellular parasitophorous vacuoles (morulae), two types of ehrlichial cells were found regularly--those with uniformly dispersed nucleoid ...
V L, Popov, S M, Chen, H M, Feng, D H, Walker   +3 more
openaire   +2 more sources

Ehrlichia chaffeensis:a Prototypical Emerging Pathogen [PDF]

Clinical Microbiology Reviews, 2003
SUMMARYEhrlichia chaffeensis is an obligately intracellular, tick-transmitted bacterium that is maintained in nature in a cycle involving at least one and perhaps several vertebrate reservoir hosts. The moderate to severe disease caused by E. chaffeensis in humans, first identified in 1986 and reported for more than 1,000 patients through 2000 ...
Paddock, Christopher D, Childs, James E.
openaire   +3 more sources

Surface-Exposed Proteins ofEhrlichia chaffeensis [PDF]

Infection and Immunity, 2007
ABSTRACTThe surface proteins ofEhrlichia chaffeensisprovide an important interface for pathogen-host interactions. To investigate the surface proteins ofE. chaffeensis, membrane-impermeable, cleavable Sulfo-NHS-SS-Biotin was used to label intact bacteria.
Yan, Ge, Yasuko, Rikihisa
openaire   +2 more sources

Structure of thymidylate kinase fromEhrlichia chaffeensis [PDF]

Acta Crystallographica Section F Structural Biology and Crystallization Communications, 2011
The enzyme thymidylate kinase phosphorylates the substrate thymidine 5'-phosphate (dTMP) to form thymidine 5'-diphosphate (dTDP), which is further phosphorylated to dTTP for incorporation into DNA. Ehrlichia chaffeensis is the etiologic agent of human monocytotropic erlichiosis (HME), a potentially life-threatening tick-borne infection.
Leibly, David J., Abendroth, Jan, Bryan, Cassie M., Sankaran, Banumathi, Kelley, Angela, Barrett, Lynn K., Stewart, Lance, Van Voorhis, Wesley C.   +7 more
openaire   +2 more sources

Ehrlichia chaffeensis infection in the reservoir host (white-tailed deer) and in an incidental host (dog) is impacted by its prior growth in macrophage and tick cell environments. [PDF]

PLoS ONE, 2014
Ehrlichia chaffeensis, transmitted from Amblyomma americanum ticks, causes human monocytic ehrlichiosis. It also infects white-tailed deer, dogs and several other vertebrates. Deer are its reservoir hosts, while humans and dogs are incidental hosts.
Arathy D S Nair, Chuanmin Cheng, Deborah C Jaworski, Lloyd H Willard, Michael W Sanderson, Roman R Ganta   +5 more
doaj   +1 more source

New insights into molecular Ehrlichia chaffeensis-host interactions [PDF]

Microbes and Infection, 2010
Ehrlichia chaffeensis is an obligately intracellular bacterium that exhibits tropism for mononuclear phagocytes and survives by reprogramming the host cell. Here we review new information regarding the newly characterized effector molecules and the complex network of molecular host-pathogen interactions that the organism exploits enabling it to thrive ...
Abdul, Wakeel, Bing, Zhu, Xue-Jie, Yu, Jere W, McBride   +3 more
openaire   +2 more sources

Experimental infection of dairy calves with Ehrlichia chaffeensis [PDF]

Journal of Medical Microbiology, 2007
Human monocytic ehrlichiosis (HME) is a zoonotic emerging tick-borne disease with clinical signs that range from mild symptoms to multiple organ failure and death.Ehrlichia chaffeensis, the aetiologic agent of HME, is reported to infect a divergent range of mammals.
Jose R C, Delos Santos, Kirsten, Boughan, William G, Bremer, Brian, Rizzo, John J, Schaefer, Yasuko, Rikihisa, Glen R, Needham, L A, Capitini, David E, Anderson, Michael, Oglesbee, S A, Ewing, Roger W, Stich   +11 more
openaire   +2 more sources

Naturally Occurring Ehrlichia chaffeensis Infection in Two Prosimian Primate Species: Ring-tailed Lemurs (Lemur catta) and Ruffed Lemurs (Varecia variegata)

Emerging Infectious Diseases, 2002
A naturally occurring infection of Ehrlichia chaffeensis in lemurs is described. DNA of Ehrlichia chaffeensis was identified by polymerase chain reaction in peripheral blood from six of eight clinically ill lemurs.
Cathy V. Williams, Jan L. Van Steenhouse, Julie M. Bradley, Susan I. Hancock, Barbara C. Hegarty, Edward B. Breitschwerdt   +5 more
doaj   +1 more source