Results 141 to 150 of about 15,176 (154)

Molecular Cloning and Sequencing of the Human Heme-regulated Eukaryotic Initiation Factor 2 Alpha (eIF-2 Alpha) Kinase from Bone Marrow Culture

DNA Sequence, 2002
The cDNA encoding human heme-regulated eukaryotic initiation factor-2 alpha (eIF-2 alpha) kinase was cloned from a human bone marrow culture. Its deduced amino acid sequence comprised of 629 amino acids with a calculated molecular weight of 71,031 Da.
Takeshi, Omasa, Yi-Guang, Chen, Athanasios, Mantalaris, Ying-Chuech, Tsai, J H David, Wu   +4 more
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The 90-kilodalton peptide of the heme-regulated eIF-2.alpha. kinase has sequence homology with the 90-kilodalton heat shock protein

Biochemistry, 1987
Highly purified preparations of the heme-controlled eIF-2 alpha (eukaryotic peptide initiation factor 2 alpha subunit) kinase of rabbit reticulocytes contain an abundant 90-kilodalton (kDa) peptide that is immunologically cross-reactive with spectrin and that modulates the activity of the enzyme [Kudlicki, W., Fullilove, S., Read, R., Kramer, G ...
D W, Rose, R E, Wettenhall, W, Kudlicki, G, Kramer, B, Hardesty   +4 more
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elF-2 kinases: regulators of general and gene-specific translation initiation

Trends in Biochemical Sciences, 1994
Phosphorylation of eukaryotic initiation factor-2 (eIF-2) is an important mechanism regulating general translation initiation. Two mammalian eIF-2 kinases, the double-stranded-RNA-dependent kinase (PKR) and heme-regulated inhibitor kinase (HRI), have been characterized by sequencing, revealing shared sequence and structural features distinct from other
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Regulation of heme-regulated eIF-2α kinase and its expression in erythroid cells

Biochimie, 1994
In this article we focus first on the molecular mechanisms controlling the activity of the heme-regulated translational inhibitor, HRI, in erythroid cells. Then we discuss the tissue-specific expression of HRI. The experimental evidence obtained to date indicates that the major physiological role of HRI is in adjusting the synthesis of globin to the ...
J J, Chen, J S, Crosby, I M, London
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Association of the Heme-Controlled eIF-2α Kinase with Spectrin-Derived Peptides

1987
Translational control of mammalian protein synthesis frequently occurs at the level of peptide initiation. One control system in particular has been intensively studied during the last decade. It involves phosphorylation and dephosphorylation of the smallest subunit (α-subunit) of initiation factor 2, eIF-2.
G, Kramer, W, Kudlicki, S, Fullilove, B, Hardesty   +3 more
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REGULATION OF PROTEIN SYNTHESIS IN RABBIT RETICULOCYTE LYSATES BY DOUBLE STRANDED RNA (dsRNA) ACTIVATED PROTEIN KINASE THAT PHOSPHORYLATES INITIATION FACTOR eIF-2

, 1981
Rajinder Singh Ranu
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The eIF-2α kinases: regulators of protein synthesis in starvation and stress

Seminars in Cell Biology, 1994
Phosphorylation of translation initiation factor 2 alpha is a highly conserved mechanism for down-regulating protein synthesis in response to starvation or stress. The yeast eIF-2 alpha kinase GCN2 is stimulated by deprivation for amino acids or purines.
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Induction of an antiviral state by interferon in the absence of elevated levels of 2,5-oligo(A) synthetase and eIF-2 kinase

Virology, 1988
A series of clones has been derived from an interferon-resistant murine cell line, Ltk- aprt-, and their antiviral properties have been characterized. In the parental Ltk- aprt- line interferon is unable to establish antiviral properties or to increase the levels of 2,5-oligo(A) synthetase, the 2,5-oligo(A)-activated endonuclease F, 2',5 ...
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Translational Control by Influenza Virus: Suppression of the Kinase That Phosphorylates the Alpha Subunit of Initiation Factor eIF-2 and Selective Translation of Influenza Viral mRNAs

, 1986
Michael G. Katze, B M Detjen, Brian Safer, Robert M. Krug   +3 more
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Analysis of eIF-2 alpha kinases in yeast.

Methods in molecular biology (Clifton, N.J.), 1999
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