Results 51 to 60 of about 15,176 (154)

Citrullination in Tumor Metastasis, Inside and Outside the Cells

Cancer Science, Volume 116, Issue 12, Page 3239-3249, December 2025.
ABSTRACT Tumor metastasis remains a poor prognosis because it occurs in all tissues and is difficult to diagnose or prevent before metastatic tumor nodules form. Metastasis is a multi‐step process involving tumor cells, bone marrow‐derived cells, and tissue resident cells, making it a biological three‐body problem.
Takeshi Tomita, Priyanka Sharma, Sachie Hiratsuka   +2 more
wiley   +1 more source

Mechanism of action of an eukaryotic initiation factor-2 (eIF-2) associated 67 kDa glycoprotein (p67) and an eIF-2 kinase (dsI).

Indian journal of biochemistry & biophysics, 1995
Mechanism of regulation of eIF-2 alpha-subunit phosphorylation by dsI and p67 was studied. The results are as follows: (1) At low dsI concentration, p67 protected equimolar concentration of eIF-2. (2) At high dsI concentration, dsI efficiently phosphorylated eIF-2 alpha-subunit even when equimolar concentrations of both p67 and eIF-2 were present ...
A, Chakraborty, D, Saha, A, Bose, R E, Hileman, M, Chatterjee, N K, Gupta   +5 more
openaire   +1 more source

Targeting the Secretin Receptor in Macrophages Attenuates Silica‐Induced Pulmonary Fibrosis

Cell Proliferation, Volume 58, Issue 12, December 2025.
Targeting macrophage SCTR mitigates integrated profibrotic, inflammatory, ER stress, and senescent pathways, preserving lung function and revealing a novel therapeutic strategy for silicosis.
Yaqian Li, Tian Li, Fuyu Jin, Shupeng Liu, Dingjie Xu, Zhongqiu Wei, Xuemin Gao, Wenchen Cai, Na Mao, Fang Yang, Haibo Zhang, Yiwei Shi, Hong Xu   +12 more
wiley   +1 more source

The stress sensor GCN2 differentially controls ribosome biogenesis in colon cancer according to the nutritional context

Molecular Oncology
Nutrient availability is a key determinant of tumor cell behavior. While nutrient‐rich conditions favor proliferation and tumor growth, scarcity, and particularly glutamine starvation, promotes cell dedifferentiation and chemoresistance.
Marie Piecyk, Mouna Triki, Pierre‐Alexandre Laval, Cedric Duret, Joelle Fauvre, Laura Cussonneau, Christelle Machon, Jerôme Guitton, Nicolas Rama, Benjamin Gibert, Gabriel Ichim, Frederic Catez, Fleur Bourdelais, Sebastien Durand, Jean‐Jacques Diaz, Isabelle Coste, Toufic Renno, Serge N. Manié, Nicolas Aznar, Stephane Ansieau, Carole Ferraro‐Peyret, Cedric Chaveroux   +21 more
doaj   +1 more source

Specifically Breaking Through the Injured Blood‐Brain Barrier With Tannic Acid‐Based Nanomedicine for Ischemic Stroke Ischemia Reperfusion Treatment

Exploration, Volume 5, Issue 5, October 2025.
Protecting neuronal mitochondria by eliminating the mitochondrial ROS (mtROS) storm is crucial to abrogate the neuronal damage cascade of ischemic stroke ischemia reperfusion (ISIR), which is a long‐standing challenge in the field of ischemic stroke (IS).
Xiaojing Shi, Shuya Wang, Tingli Xiong, Ruishi Li, Wenxuan Zheng, Wensheng Chen, Tianjiao Zhao, Yongqi Yang, Xiaohong Ying, Weimin Qi, Yingci Xia, Jue Wang, Yuqi Zhang, Qiong Huang, Yayun Nan, Kelong Ai   +15 more
wiley   +1 more source

Disulfide bond formation in the regulation of eIF-2 alpha kinase by heme.

The Journal of biological chemistry, 1989
The inhibition of the autophosphorylation of the heme-regulated eukaryotic initiation factor (eIF)-2 alpha kinase (HRI) by hemin is very similar to that produced by thiol oxidation by diamide. The results obtained from the analysis of sodium dodecyl sulfate-polyacrylamide gel electrophoresis of unphosphorylated and phosphorylated HRI under reducing and
J J, Chen, J M, Yang, R, Petryshyn, N, Kosower, I M, London   +4 more
openaire   +1 more source

Promising Cancer Vaccine for Glioblastoma Therapy: A Focus on mRNA Vaccine

Cancer Medicine, Volume 14, Issue 18, September 2025.
ABSTRACT Background Glioblastoma (GBM) is an aggressive primary brain tumor with poor prognosis and low survival rates. Standard treatments, such as surgery and radiotherapy, are limited by tumor infiltration and resistance. To review current vaccine strategies for GBM, including peptide, virotherapy, cell‐based, and genetic vaccines, with a focus on ...
Sama Barati, Sahar Ghoflchi, Pejman Hosseinzadeh, Sobhan Pouramini, Hossein Hosseini, Mohammad Jalili‐Nik   +5 more
wiley   +1 more source

Discovery of RNA‐Targeting Small Molecules: Challenges and Future Directions

MedComm, Volume 6, Issue 9, September 2025.
This review explores challenges and future directions in discovering RNA‐targeting small molecules, from analyzing RNA structures and computational design to experimental workflows. It discusses mechanistic strategies like splicing modulation and RNA degradation, alongside advanced tools (deep learning, docking, and validation) to accelerate drug ...
Zhengguo Cai, Hongli Ma, Fengcan Ye, Dingwei Lei, Zhenfeng Deng, Yongge Li, Ruichu Gu, Han Wen   +7 more
wiley   +1 more source

Hsp90 mediates activation of the heme regulated eIF-2 alpha kinase during oxidative stress.

Indian journal of biochemistry & biophysics, 2010
The heme-regulated inhibitor (HRI), a member of the eIF-2 alpha kinase family is crucial for regulating protein synthesis during stress. In addition to heme, stress proteins Hsp90 and Hsp70 are known to regulate HRI. The present study aims to determine the physical association of these Hsps in the regulation of HRI activation during oxidative stress ...
A P, Kulkarni, S P, Mittal, T P A, Devasagayam, J K, Pal   +3 more
openaire   +1 more source

Advances in Single‐Cell Sequencing for Infectious Diseases: Progress and Perspectives

Advanced Science, Volume 12, Issue 32, August 28, 2025.
Single‐cell sequencing technologies uncover novel, unknown, and emergent features of many diseases. This review describes recent progress of single‐cell sequencing technologies and their applications in infectious diseases, summarizes the underlying commonalities of different infections and discusses future research directions, facilitating the ...
Mengyuan Lyu, Yang Liu, Jian Zhou, Hongli Lai, Hongxia Ruan, Dongsheng Wu, Shun Zhu, Xudong Zhou, Wananqi Ma, Yuchen Huang, Shuting Lei, Han Luo, Jie Chen, Binwu Ying   +13 more
wiley   +1 more source