Phospholipid‐sensitive Ca2+‐dependent protein kinase phosphorylates the β subunit of eukaryotic initiation factor 2 (eIF‐2) [PDF]
FEBS Letters, 1983 The ability of homogeneous phospholipid‐sensitive Ca2+‐dependent protein kinase (PL‐Ca‐PK) from pig spleen to phosphorylate eukaryotic initiation factor 2 (eIF‐2) was examined. PL‐Ca‐PK phosphorylated the β‐subunit of eIF‐2, whereas myosin light chain kinase (MLCK) and cyclic AMP‐ and cyclic GMP‐dependent protein kinases (cA‐PK and cG‐PK) did not.
William C. Merrick +3 more
openaire +3 more sources
Regulation of the interactions between human eIF5 and eIF1A by the CK2 kinase
Current Research in Structural Biology, 2022 Translation initiation in eukaryotes relies on a complex network of interactions that are continuously reorganized throughout the process. As more information becomes available about the structure of the ribosomal preinitiation complex (PIC) at various ...
Nathan Gamble +3 more
doaj
An in vivo control map for the eukaryotic mRNA translation machinery [PDF]
, 2013 Rate control analysis defines the in vivo control map governing yeast protein synthesis and generates an extensively parameterized digital model of the translation pathway.
Amy Claydon +12 more
core +2 more sources
ADAR1 restricts LINE-1 retrotransposition [PDF]
, 2016 Adenosine deaminases acting on RNA (ADARs) are involved in RNA editing that converts adenosines to inosines in double-stranded RNAs. ADAR1 was demonstrated to be functional on different viruses exerting either antiviral or proviral effects.
Antonioni, Ambra +9 more
core +2 more sources
Transcriptome Analysis in Spleen Reveals Differential Regulation of Response to Newcastle Disease Virus in Two Chicken Lines. [PDF]
, 2018 Enhancing genetic resistance of chickens to Newcastle Disease Virus (NDV) provides a promising way to improve poultry health, and to alleviate poverty and food insecurity in developing countries.
Bunn, David A +8 more
core +3 more sources
Orchestrated transcription of biological processes in the marine picoeukaryote Ostreococcus exposed to light/dark cycles [PDF]
, 2010 Background: Picoeukaryotes represent an important, yet poorly characterized component of marine phytoplankton. The recent genome availability for two species of Ostreococcus and Micromonas has led to the emergence of picophytoplankton comparative ...
Bouget, François-Yves +7 more
core +7 more sources
Cell cycle progression or translation control is not essential for vesicular stomatitis virus oncolysis of hepatocellular carcinoma. [PDF]
, 2010 The intrinsic oncolytic specificity of vesicular stomatitis virus (VSV) is currently being exploited to develop alternative therapeutic strategies for hepatocellular carcinoma (HCC). Identifying key regulators in diverse transduction pathways that define
Altomonte, Jennifer +9 more
core +7 more sources
Translation inhibition by rocaglates is independent of eIF4E phosphorylation status [PDF]
, 2016 Rocaglates are natural products that inhibit protein synthesis in eukaryotes and exhibit antineoplastic activity. In vitro biochemical assays, affinity chromatography experiments coupled with mass spectrometry analysis, and in vivo genetic screens have ...
Cencic, Regina +4 more
core +1 more source
A rapamycin-sensitive signaling pathway contributes to long-term synaptic plasticity in the hippocampus [PDF]
, 2002 Many forms of long-lasting behavioral and synaptic plasticity require the synthesis of new proteins. For example, long-term potentiation (LTIP) that endures for more than an hour requires both transcription and translation.
Gingras, Anne-Claude +5 more
core
The translational repressors Nanos and Pumilio have divergent effects on presynaptic terminal growth and postsynaptic glutamate receptor subunit composition [PDF]
, 2009 Pumilio (Pum) is a translational repressor that binds selectively to target mRNAs and recruits Nanos (Nos) as a corepressor. In the larval neuromuscular system, Pum represses expression of the translation factor eIF-4E and the glutamate receptor subunit ...
Andrews, Shane +4 more
core +1 more source