Results 31 to 40 of about 224 (106)

Mechanistic Insights and Therapeutic Potentials of Ubiquitin‐Proteasome System in Non‐Small Cell Lung Cancer

Cell Proliferation, Volume 58, Issue 7, July 2025.
Lung cancer development involves mechanisms like reduced EGFR/EGF ubiquitination driving cancer cell behaviors and immune evasion via loss of PD‐1/PD‐L1 ubiquitination. Balancing ubiquitination and deubiquitination may be a potential therapeutic strategy. ABSTRACT Non‐small cell lung cancer (NSCLC) remains a leading cause of cancer mortality.
Guangyao Zhou, Jiaxiong Tan, Pengpeng Zhang, Zhaokai Zhou, Lianmin Zhang, Zhenfa Zhang   +5 more
wiley   +1 more source

SEC‐SAXS/MC Ensemble Structural Studies of the Microtubule Binding Protein Cdt1 Show Monomeric, Folded‐Over Conformations

Cytoskeleton, Volume 82, Issue 6, Page 372-387, June 2025.
ABSTRACT Cdt1 is a mixed folded protein critical for DNA replication licensing and it also has a “moonlighting” role at the kinetochore via direct binding to microtubules and the Ndc80 complex. However, it is unknown how the structure and conformations of Cdt1 could allow it to participate in these multiple, unique sets of protein complexes.
Kyle P. Smith, Srinivas Chakravarthy, Amit Rahi, Manas Chakraborty, Kristen M. Vosberg, Marco Tonelli, Maximilian G. Plach, Arabela A. Grigorescu, Joseph E. Curtis, Dileep Varma   +9 more
wiley   +1 more source

The Politics of Life and Death: Mexican Narconarratives at the Edge of the Twenty-first Century

, 2018
This dissertation examines the link between sovereignty, law, community and (il)legal violence in 20th/21st century Mexican narratives associated with drug trafficking themes.
Diaz-Davalos, Angel Martin
core   +1 more source

RNA‐Binding Proteome‐Wide Analysis Reveals Rice RNA‐Binding Proteins Enriched After Sobemovirus Rice Yellow Mottle Virus Infection

Plant Direct, Volume 9, Issue 5, May 2025.
ABSTRACT RNA‐binding protein interactions with viral RNA are crucial in the context of viral infections, as viral RNAs can recruit and reprogram host RNA‐binding proteins (RBPs) during disease progression. Despite their significance, the repertoire of RBPs involved in most viral infections remains inadequately characterized. In Africa, Sobemovirus Rice
Patrick Jacob Odongo, Roosje Van Ende, Sam Balzarini, Geoffrey Onaga, Titus Alicai, Koen Geuten   +5 more
wiley   +1 more source

A cascading activity-based probe sequentially targets E1–E2–E3 ubiquitin enzymes

, 2016
Cancer Signaling networks and Molecular ...
Schulman, B.A., Ilana Berlin, Ovaa, H., Groettrup, M., Neefjes, J., Merkx, R., Farid El Oualid, Jer-Gung Chang, Jacques Neefjes, David Komander, Mulder, M.P.C., Komander, D., Monique P C Mulder, Berlin, I., Remco Merkx, Vertegaal, A.C.O., Witting, K., Johanna Bialas, Alfred C O Vertegaal, Chang, J.G., Wu, K.P., Kuen-Phon Wu, Jonathan N Pruneda, Pruneda, J.N., Katharina Witting, Oualid, F. el, Marcus Groettrup, Huib Ovaa, Bialas, J., Brenda A Schulman   +29 more
core   +1 more source

The disordered negatively charged C‐terminus of the large HECT E3 ubiquitin ligase HERC2 provides structural and thermal stability to the HECT C‐lobe

Protein Science, Volume 33, Issue 12, December 2024.
Abstract Homologous to the C‐terminus of E6AP (HECT) and RCC1‐like domain (RLD)‐containing protein 2 (HERC2) is a large, 528 kDa E3 ubiquitin ligase that is associated with cancer, oculocutaneous albanism type 2, Prader‐Willi syndrome, and other neurological diseases.
Kelly L. Waters, Kayla J. Rich, Noah D. Schwaegerle, Tianyi Yang, Shuanghong Huo, Donald E. Spratt   +5 more
wiley   +1 more source

OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis

, 2013
Sixteen ovarian tumor (OTU) family deubiquitinases (DUBs) exist in humans, and most members regulate cell-signaling cascades. Several OTU DUBs were reported to be ubiquitin (Ub) chain linkage specific, but comprehensive analyses are missing, and the ...
Arnaudo, Nadia, Ekkebus, Reggy, El Oualid, Farid, Geurink, Paul P., Komander, David, Mevissen, Tycho E. T., Akutsu, Masato, Wauer, Tobias, Freund, Stefan M.V., Elliott, Paul R., Hospenthal, Manuela; id_orcid, Freund, Stefan M. V., Mevissen, Tycho E.T., Hospenthal, Manuela K., Kulathu, Yogesh, Ovaa, Huib   +15 more
core   +1 more source

Genomic and biogeographic characterisation of the novel prasinovirus Mantoniella tinhauana virus 1

Environmental Microbiology Reports, Volume 16, Issue 5, October 2024.
Phylogenetic tree, virion morphology and global metagenomic abundance of Mantoniella tinhauana virus 1, a newly isolated and characterised prasinovirus. Abstract Mamiellophyceae are a ubiquitous class of unicellular green algae in the global ocean.
Elvira Rey Redondo, Shara Ka Kiu Leung, Charmaine Cheuk Man Yung   +2 more
wiley   +1 more source

Biallelic OTUD6B variants associated with a Kabuki syndrome‐like disorder in three siblings: A clinical report and literature review

American Journal of Medical Genetics Part A, Volume 194, Issue 7, July 2024.
Abstract Biallelic variants in the OTUD6B gene have been reported in the literature in association with an intellectual developmental disorder featuring dysmorphic facies, seizures, and distal limb abnormalities. Physical differences described for affected individuals suggest that the disorder may be clinically recognizable, but previous publications ...
Balram Gangaram, Virgina Lee, Anne Slavotinek   +2 more
wiley   +1 more source

Integrating multi‐omics data reveals energy and stress signaling activated by abscisic acid in Arabidopsis

The Plant Journal, Volume 119, Issue 2, Page 1112-1133, July 2024.
SUMMARY Phytohormones are essential signaling molecules regulating various processes in growth, development, and stress responses. Genetic and molecular studies, especially using Arabidopsis thaliana (Arabidopsis), have discovered many important players involved in hormone perception, signal transduction, transport, and metabolism.
Takuya Yoshida, Julia Mergner, Zhenyu Yang, Jinghui Liu, Bernhard Kuster, Alisdair R. Fernie, Erwin Grill   +6 more
wiley   +1 more source