Reading and Writing the Ubiquitin Code Using Genetic Code Expansion
ChemBioChem, Volume 25, Issue 11, June 3, 2024.Deciphering the ubiquitin code and the function of ubiquitin proteoforms has been a long‐standing challenge in the field. This review discusses the use of genetic code expansion towards genetically directed ubiquitination strategies, small chemical modifications on ubiquitin, and tools to survey ubiquitin‐protein interactions.
Rishi S. Patel +2 more
wiley +1 more source
Degradation meets development: Implications in β‐cell development and diabetes
Cell Biology International, Volume 48, Issue 6, Page 759-776, June 2024.Abstract Pancreatic development is orchestrated by timely synthesis and degradation of stage‐specific transcription factors (TFs). The transition from one stage to another stage is dependent on the precise expression of the developmentally relevant TFs.
Akshaya Ashok +2 more
wiley +1 more source
A fluorescence‐based sensor for calibrated measurement of protein kinase stability in live cells
Protein Science, Volume 33, Issue 6, June 2024.Abstract Oncogenic mutations can destabilize signaling proteins, resulting in increased or unregulated activity. Thus, there is considerable interest in mapping the relationship between mutations and the stability of signaling proteins, to better understand the consequences of oncogenic mutations and potentially inform the development of new ...
Joseph W. Paul III +2 more
wiley +1 more source
Protein Science, Volume 33, Issue 4, April 2024.Abstract Deltex proteins are a family of E3 ubiquitin ligases that encode C‐terminal RING and DTC domains that mediate interactions with E2 ubiquitin‐conjugating enzymes and recognize ubiquitination substrates. DTX3L is unique among the Deltex proteins based on its N‐terminal domain architecture.
Carlos Vela‐Rodríguez +10 more
wiley +1 more source
Structural and functional validation of a highly specific Smurf2 inhibitor
Protein Science, Volume 33, Issue 2, February 2024.Abstract Smurf1 and Smurf2 are two closely related member of the HECT (homologous to E6AP carboxy terminus) E3 ubiquitin ligase family and play important roles in the regulation of various cellular processes. Both were initially identified to regulate transforming growth factor‐β and bone morphogenetic protein signaling pathways through regulating Smad
Tanner M. Tessier +12 more
wiley +1 more source
USP10 deubiquitylates and stabilizes DIRAS2 to suppress the growth of pancreatic cancer cells
MedComm, Volume 5, Issue 10, October 2024.
Qian Chen, Xiufang Xiong, Yi Sun
wiley +1 more source
Actividad del sistema Ubiquitina proteosoma sobre la proteína NS1 del virus dengue 2
, 2017 El virus Dengue (DENV) es un miembro de la familia Flaviviridae.Materiales y métodos 48Resultados 59Discusión 73Conclusiones 80Perspectivas 81DoctoradoDoctor en Ciencias ...
Giraldo Giraldo, María Isabel
core
Maternal effects on oocyte quality in farmed Atlantic halibut (Hippoglossus hippoglossus L.)
, 2013 Atlantic halibut (Hippoglossus hippoglossus) oocyte quality is highly variable and one of the major bottlenecks during fry-production for on-growth in commercial Atlantic halibut farming.
Mommens, Maren
core
The effect of glucose on cardiac AMP-activated protein kinase
, 2009 AMP-activated protein kinase (AMPK) serves as an energy-sensing protein that is activated by a variety of metabolic stresses. Recent studies suggest that AMPK is also regulated by hormones and by nutrients such as glucose and fatty acids.
Tabidi, I.
core
K27-linked ubiquitylation promotes p97 substrate processing and is essential for cell proliferation. [PDF]
EMBO J, 2022 Shearer RF +6 more
europepmc +1 more source