Results 21 to 30 of about 14,886,010 (66)

RNA‐Binding Proteome‐Wide Analysis Reveals Rice RNA‐Binding Proteins Enriched After Sobemovirus Rice Yellow Mottle Virus Infection

Plant Direct, Volume 9, Issue 5, May 2025.
ABSTRACT RNA‐binding protein interactions with viral RNA are crucial in the context of viral infections, as viral RNAs can recruit and reprogram host RNA‐binding proteins (RBPs) during disease progression. Despite their significance, the repertoire of RBPs involved in most viral infections remains inadequately characterized. In Africa, Sobemovirus Rice
Patrick Jacob Odongo, Roosje Van Ende, Sam Balzarini, Geoffrey Onaga, Titus Alicai, Koen Geuten   +5 more
wiley   +1 more source

Dynamic networks connect the USP14 active site region with the proteasome interaction surface

Protein Science, Volume 34, Issue 4, April 2025.
Abstract Ubiquitin‐specific protease 14 (USP14) is a member of the USP family responsible for the catalytic removal of ubiquitin (Ub) from proteins directed to the proteasome, implicated in the pathogenesis of neurodegeneration and cancer. Crystallography and cryo‐EM analysis have identified loop regions crucial for the deubiquitinase activity of USP14,
Johannes Salomonsson, Linda Sjöstrand, Arvid Eskilson, Dean Derbyshire, Pádraig D'Arcy, Maria Sunnerhagen, Alexandra Ahlner   +6 more
wiley   +1 more source

The disordered negatively charged C‐terminus of the large HECT E3 ubiquitin ligase HERC2 provides structural and thermal stability to the HECT C‐lobe

Protein Science, Volume 33, Issue 12, December 2024.
Abstract Homologous to the C‐terminus of E6AP (HECT) and RCC1‐like domain (RLD)‐containing protein 2 (HERC2) is a large, 528 kDa E3 ubiquitin ligase that is associated with cancer, oculocutaneous albanism type 2, Prader‐Willi syndrome, and other neurological diseases.
Kelly L. Waters, Kayla J. Rich, Noah D. Schwaegerle, Tianyi Yang, Shuanghong Huo, Donald E. Spratt   +5 more
wiley   +1 more source

Genomic and biogeographic characterisation of the novel prasinovirus Mantoniella tinhauana virus 1

Environmental Microbiology Reports, Volume 16, Issue 5, October 2024.
Phylogenetic tree, virion morphology and global metagenomic abundance of Mantoniella tinhauana virus 1, a newly isolated and characterised prasinovirus. Abstract Mamiellophyceae are a ubiquitous class of unicellular green algae in the global ocean.
Elvira Rey Redondo, Shara Ka Kiu Leung, Charmaine Cheuk Man Yung   +2 more
wiley   +1 more source

Biallelic OTUD6B variants associated with a Kabuki syndrome‐like disorder in three siblings: A clinical report and literature review

American Journal of Medical Genetics Part A, Volume 194, Issue 7, July 2024.
Abstract Biallelic variants in the OTUD6B gene have been reported in the literature in association with an intellectual developmental disorder featuring dysmorphic facies, seizures, and distal limb abnormalities. Physical differences described for affected individuals suggest that the disorder may be clinically recognizable, but previous publications ...
Balram Gangaram, Virgina Lee, Anne Slavotinek   +2 more
wiley   +1 more source

Integrating multi‐omics data reveals energy and stress signaling activated by abscisic acid in Arabidopsis

The Plant Journal, Volume 119, Issue 2, Page 1112-1133, July 2024.
SUMMARY Phytohormones are essential signaling molecules regulating various processes in growth, development, and stress responses. Genetic and molecular studies, especially using Arabidopsis thaliana (Arabidopsis), have discovered many important players involved in hormone perception, signal transduction, transport, and metabolism.
Takuya Yoshida, Julia Mergner, Zhenyu Yang, Jinghui Liu, Bernhard Kuster, Alisdair R. Fernie, Erwin Grill   +6 more
wiley   +1 more source

Reading and Writing the Ubiquitin Code Using Genetic Code Expansion

ChemBioChem, Volume 25, Issue 11, June 3, 2024.
Deciphering the ubiquitin code and the function of ubiquitin proteoforms has been a long‐standing challenge in the field. This review discusses the use of genetic code expansion towards genetically directed ubiquitination strategies, small chemical modifications on ubiquitin, and tools to survey ubiquitin‐protein interactions.
Rishi S. Patel, Nipuni M. Pannala, Chittaranjan Das   +2 more
wiley   +1 more source

Degradation meets development: Implications in β‐cell development and diabetes

Cell Biology International, Volume 48, Issue 6, Page 759-776, June 2024.
Abstract Pancreatic development is orchestrated by timely synthesis and degradation of stage‐specific transcription factors (TFs). The transition from one stage to another stage is dependent on the precise expression of the developmentally relevant TFs.
Akshaya Ashok, Guruprasad Kalthur, Anujith Kumar   +2 more
wiley   +1 more source

A fluorescence‐based sensor for calibrated measurement of protein kinase stability in live cells

Protein Science, Volume 33, Issue 6, June 2024.
Abstract Oncogenic mutations can destabilize signaling proteins, resulting in increased or unregulated activity. Thus, there is considerable interest in mapping the relationship between mutations and the stability of signaling proteins, to better understand the consequences of oncogenic mutations and potentially inform the development of new ...
Joseph W. Paul III, Serena Muratcioğlu, John Kuriyan   +2 more
wiley   +1 more source

Oligomerization mediated by the D2 domain of DTX3L is critical for DTX3L‐PARP9 reading function of mono‐ADP‐ribosylated androgen receptor

Protein Science, Volume 33, Issue 4, April 2024.
Abstract Deltex proteins are a family of E3 ubiquitin ligases that encode C‐terminal RING and DTC domains that mediate interactions with E2 ubiquitin‐conjugating enzymes and recognize ubiquitination substrates. DTX3L is unique among the Deltex proteins based on its N‐terminal domain architecture.
Carlos Vela‐Rodríguez, Chunsong Yang, Heli I. Alanen, Rebeka Eki, Tarek A. Abbas, Mirko M. Maksimainen, Tuomo Glumoff, Ramona Duman, Armin Wagner, Bryce M. Paschal, Lari Lehtiö   +10 more
wiley   +1 more source