Results 21 to 30 of about 224 (106)

The molecular basis of CRL4 ubiquitin ligase architecture, targeting and regulation [PDF]

, 2013
Members of the CUL4-RBX1-DDB1 (CRL4) E3 ubiquitin ligase family regulate multiple cellular processes including development, transcription, and DNA repair.
Fischer, Eric Sebastian
core   +1 more source

The role of raptor during brain development and in adult forebrain neurons [PDF]

, 2012
mTOR is a serine/threonine protein kinase that appears in two functionally distinct multi-protein complexes. mTOR together with the scaffold protein raptor forms mTOR complex1 (mTORC1) that is inhibited in its function by rapamycin.
Lustenberger, Regula Maria
core   +1 more source

Identificación y caracterización de desubiquitinasas que modulan el receptor de neurotrofinas TrkA

, 2014
[ES]El receptor TrkA es una proteína tirosina quinasa que se activa por la unión de la neurotrofina denominada Factor de Crecimiento Nervioso (NGF) desencadenando diferentes cascadas de señalización (Arévalo JC. & Wu SH., 2006).
Anta Rodríguez, Begoña
core   +1 more source

The E3 Ubiquitin Ligase UBE3B Regulates Synaptic Development and Cortical Network Activity

Autism Research, Volume 19, Issue 5, May 2026.
ABSTRACT Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by impaired communication, abnormal social interactions, and restricted, repetitive behaviors. Pathogenic mutations in UBE3B result in neurodevelopmental disease, including intellectual disability, lack of speech, and ASD.
Shayal Vashisth, Aleya Shedd, Ariel Aiken, Solmi Cheon, Josh Bandopadhay, Kiran Kaur, Kimberly M. Huber, Maria H. Chahrour   +7 more
wiley   +1 more source

Mecanismos discursivos en los corridos mexicanos de presentación del “Movimiento Alterado [PDF]

, 2013
This article is a first approach to the forms of linguistic and audiovisualrepresentation of lyrics of the commonly known “movimiento alterado” (alteredmovement) or “corrido alterado” which shows a new modality of the Mexican“narco-corrido.” For this ...
Karam Cárdenas, Tanius
core  

Advances and opportunities for computational interrogation of plant proteins

The Plant Journal, Volume 126, Issue 3, May 2026.
SUMMARY Plants exhibit remarkable biochemical and physiological diversity, and are capable of adapting to a wide range of environmental conditions and stresses. This complexity makes them essential systems for understanding how life responds to a changing climate.
Sarah M. Bohling, Shaila Musharoff, Laura H. Gunn   +2 more
wiley   +1 more source

Inverse Spillover and Dimensionality Effects on Interstitial Hydrogen

Advanced Materials Interfaces, Volume 12, Issue 23, December 8, 2025.
Interstitial hydrogen behaves distinctly at interfaces compared to the bulk. Vanadium films show proximity‐dependent hydrogen depletion near interfaces–an inverse of hydrogen spillover. Ion beam and resistivity measurements reveal Fe/V‐superlattices have lower hydrogen solubility and higher critical temperature than Cr/V due to proximity‐induced finite
Kristina Komander, Gunnar K. Pálsson, Sotirios A. Droulias, Theofanis Tsakiris, David Sörme, Max Wolff, Daniel Primetzhofer   +6 more
wiley   +1 more source

Ubiquitin-specific protease USP25 functions in endoplasmic reticulum-associated degradation

, 2012
Endoplasmic Reticulum (ER)-associated degradation (ERAD) discards abnormal proteins synthesized in the ER. Through coordinated actions of ERAD components, misfolded/anomalous proteins are recognized, ubiquitinated, extracted from the ER and ultimately ...
Amanda Denuc, Marfany Gemma, Denuc Isern, Amanda, Todi, S. V., Burr, A. A., Gemma Marfany, Blount Jessica R., Sokol V Todi, Todi Sokol V., Marfany i Nadal, Gemma, Jessica R Blount, Denuc Amanda, Blount, J. R., Aaron A Burr, Burr Aaron A.   +14 more
core   +1 more source

USP5‐Rich Apoptotic Extracellular Vesicles Regulate Nucleus Pulposus Cells Apoptosis and DNA Damage Repair by Preventing E2F1 Proteasomal Degradation

Journal of Extracellular Vesicles, Volume 14, Issue 8, August 2025.
NPCs of degenerated discs exhibit abnormal subcellular localization of the deubiquitinase USP5, with excessive cytoplasmic retention leading to aberrant ubiquitination and degradation of the nuclear transcription factor E2F1. Following transplantation into the degenerative disc microenvironment, MSCs undergo extensive apoptosis in the short‐term and ...
Pengzhi Shi, Haiyang Gao, Zhangrong Cheng, Wenbo Wu, Anran Zhang, Xianglong Chen, Wang Wu, Yukun Zhang   +7 more
wiley   +1 more source

An ankyrin-repeat ubiquitin-binding domain determines TRABID's specificity for atypical ubiquitin chains

, 2011
Eight different types of ubiquitin linkages are present in eukaryotic cells that regulate diverse biological processes. Proteins that mediate specific assembly and disassembly of atypical Lys6, Lys27, Lys29 and Lys33 linkages are mainly unknown.
Virdee, Satpal; id_orcid, El Oualid, Farid, Licchesi, Julien D. F., Mieszczanek, Juliusz, Komander, David, Mevissen, Tycho E. T., Trevor J Rutherford, Akutsu, Masato, Rutherford, Trevor J., Chin, Jason W., Satpal Virdee, Farid El Oualid, Tycho E T Mevissen, Bienz, Mariann, Masato Akutsu, Jason W Chin, David Komander, Julien D F Licchesi, Juliusz Mieszczanek, Mariann Bienz, Huib Ovaa, Ovaa, Huib   +21 more
core   +1 more source